A composition comprising an insulin-polymer conjugate and an insulin aptamer-glucagon conjugate is described. Depending upon the amount of insulin in the environment surrounding the composition, the insulin aptamer of the insulin aptamer-glucagon conjugate can bind to insulin in the insulin-polymer conjugate to form a non-covalent conjugate. When the amount of insulin in the surrounding environment rises, the insulin aptamer-glucagon conjugate can be released. Thus, the composition can be used to deliver glucagon in an insulin responsive manner. The composition can be loaded into microneedles, for example, to prepare microneedle arrays for skin patches. Methods of delivering glucagon to a subject are also described.

A template (100) for controlling application of material (620) around a protuberance (610) is disclosed. The protuberance (610) extends from a workpiece (600) and has a base (612). The template (100) comprises a first portion (110) and a second portion (130), removably attached to the first portion (110). The first portion (110) comprises a first inner peripheral edge (111) that at least partially defines a positioning opening (115) and that is geometrically complementary to at least a portion of the base (612) of the protuberance (610). The first portion (110) also comprises a first-portion environment-facing surface (114). The second portion (130) comprises a second-portion environment-facing surface (136), which partially overlaps with and is removably attached to the first-portion workpiece-facing surface (114), forming an interface (120) between the first-portion workpiece-facing surface (114) and the second-portion environment-facing surface (136).

A functional polymeric cutting edge structure and methods for manufacturing cutting edge structures using polymeric materials are provided. A razor blade for use in a razor cartridge or a blade box for assembly in a razor cartridge frame may be formed using the present invention.

The application discloses an a method of forming a lower friction eartip when compared to a pretreated elastomer eartip.

A lip balm applicator product comprises upper and lower portions that are connectable together to define the applicator product being of a substantially spherical shape. A support platform is located in the lower portion and accommodates a quantity of lip balm having an arcuate surface. A lip balm comprises a composition of waxes and oils in solid form and formed to have an arcuate surface. The composition is formed to have the arcuate surface using a hot pour process. A method of manufacturing a lip balm comprises providing a receptacle having a concave arcuate surface. A lip balm material in a heated, liquefied phase is poured into the receptacle. Once poured, the heated, liquefied phase is allowed to solidify such that a surface of the solidified lip balm material has an arcuate configuration that corresponds to the concave arcuate surface of the receptacle.

A daylighting device according to an aspect of the invention includes at least a daylighting film that includes a base having optical transparency and daylighting portions having optical transparency and provided on one surface of the base. Each of the daylighting portions has a reflective surface by which light incident on the daylighting portion is reflected and the light reflected by the reflective surface and output from a second surface of the base has a characteristic that the light travels toward a space on a side where the light is incident on the reflective surface, the space being one of two spaces divided by a virtual plane as a boundary which is vertical to the second surface of the first substrate and parallel to a direction of the daylighting portion extending, and intervals s between adjacent daylighting portions are set to various values.

An apparatus for cultivation of cells, particularly podocytes, is described. The apparatus includes a cell cultivation surface exhibiting at least one feature providing a non-planar microtopology. A method for cultivation of cells, particularly podocytes, is also described. The method includes introducing a differentiation media including ATRA, Vit D3, and Dex.

A method of aligning a stencil to an eyepiece wafer includes providing the stencil, positioning the stencil with respect to a first light source, and determining locations of at least two stencil apertures. The method also includes providing the eyepiece wafer. The eyepiece wafer includes at least two eyepiece waveguides, each eyepiece waveguide including an incoupling grating and a corresponding diffraction pattern. The method further includes directing light from one or more second light sources to impinge on each of the corresponding diffraction patterns, imaging light diffracted from each incoupling grating, determining at least two incoupling grating locations, determining offsets between corresponding stencil aperture locations and incoupling grating locations, and aligning the stencil to the eyepiece wafer based on the determined offsets.

Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.

Provided is a molded article that has such a shape as to offer a light condensing or light diffusing effect, has excellent mechanical strengths and heat resistance, and has a high thickness deviation ratio. This molded article includes a cured product of a curable composition containing an epoxy compound (A). The cured product has a flexural modulus of 2.5 GPa or more as measured in conformity with JIS K 7171:2008, except for performing measurement on a test specimen having a length of 20 mm, a width of 2.5 mm, and a thickness of 0.5 mm and at a span between specimen supports of 16 mm. The molded article has a thickness deviation ratio (thickest portion thickness to thinnest portion thickness ratio) of 5 or more and offers a light condensing or light diffusing effect. The molded article preferably has a thinnest portion thickness of 0.2 mm or less. The curable composition is preferably a photocurable composition.