Provided are a production method of a mold, a manufacturing method of a pattern sheet, a production method of an electroform, a production method of a mold using an electroform, and an original. The production method includes: preparing an original having an inclined portion which is formed in an enclosed shape on an outer peripheral portion of a protruding pattern formed at a center portion on a base and gradually increases in thickness from inside toward outside, and a thermoplastic resin sheet; and forming a recessed pattern on the thermoplastic resin sheet by pressing the original which is heated against the thermoplastic resin sheet at a position where a flat surface of the original and a surface of the thermoplastic resin sheet are separated from each other, cooling the original in the state where the original is pressed, and separating the original from the thermoplastic resin sheet.

A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

This invention relates to an impression-taking pad (10) for taking an impression (20) of an ear canal (30) by an impression-taking material, having a lateral end (el) to be arranged away from a tympanic membrane (35) in said ear canal (30); and a medial end (em) to be arranged proximate to said tympanic membrane (35). The impression-taking pad (10) comprises an outer body (2) tapering from said lateral end (el) to said medial end (em). The impression-taking pad (10) further comprises an inner body (3) for releasable engagement with a tool (11, 12) for visual inspection of the ear canal (30), the inner body (3) being configured to support insertion of the impression-taking pad (10) in the ear canal (30) by the tool (11, 12). The impression-taking pad (10) comprises a duct (5) at least partially defmed by the inner body (3), forming at least part of an optical path for visual inspection of the ear canal (30); wherein the optical path further comprises an inspection window (6), closing said duct (5), configured to support inspection of the ear canal (30) during the insertion of the impression-taking pad (10) in the ear canal (30); The impression-taking pad (10) is further configured to form an integral part of said impression (20). The present invention also relates to a method of taking an impression by the above defmed impression-taking pad (10); as well as to a correlated impression-taking system comprising an aptly modified tool (11, 12) to cooperate with such an impression-taking pad (10).

The subject matter of the present invention is a device for guiding cell migration comprising a substrate having a textured surface intended to be brought into contact with cells, said textured surface having an anisotropic three-dimensional structure consisting of a network of projections inclined relative to the normal to the plane formed by said textured structure, in the direction imparted by said anisotropic structure. The invention also concerns, according to another aspect, a method for guiding cell migration including the bringing into contact of cells with a substrate having a textured surface and an anisotropic three-dimensional structure, said structure consisting of projections inclined as previously described. The device or method according to the invention can in particular be applied in the fields of dermatology, implantology and tissue engineering.

Disclosed is a method for manufacturing a soundproofing board part having improved sound absorption performance. The soundproofing board part is manufactured by using, as a material, a recycled soundproofing material which contains a polyurethane foam having excellent sound absorption performance and impact resilience during the press molding; and by producing a sound absorption part on the back surface of the soundproofing board part through a remolding processing method. Also disclosed is a soundproofing board part manufactured by the method. Accordingly, sound absorption performance of the soundproofing board part is improved by about 20% or greater, manufacturing cost thereof may be reduced by recycled resources utilizing waste sheets, and manufacturing process may be simplified compared the related art.

The present invention relates to a microneedle comprising a plurality of portions, wherein the plurality of portions comprise a distal end portion and a proximal end portion, at least two of the plurality of portions are made of different polymers, and the distal end portion is made of at least one polymer with high swellability and high viscoelasticity.

To provide a microneedle array which includes a sheet and needles, improves transfer of a medicament into the blood, and is capable of achieving high drug efficacy.

Provided is a microneedle array including: a sheet; and a plurality of needles present on the upper surface of the sheet, in which the needles contain a water-soluble polymer and a medicament, the sheet contains a water-soluble polymer, and the administration is performed such that 20 μm≦L2≦L−L1 is satisfied, here, L represents the length of a needle, L1 represents the length of a needle tip region, which contains 90% of the total medicament in the microneedle array, from the needle tip, L2 represents the average remaining length of the needle after administration using the microneedle array, and the unit of L, L1, and L2 is μm.

The present invention is directed to a golf ball having a cover in which the dimples have two distinct hardness regions. The cover of the present invention is formed from a castable formulation including at least one prepolymer that incorporates some degree of unsaturation in the backbone of the polymer, at least one curative, and at least one free radical initiator. The present invention also explores the methods of making such golf balls. The methods of the present invention allow for the production of a golf ball dimple with two distinct hardnesses to be formed using a single castable formulation.

Disclosed is a pouch (also called a flexible container) for holding fluid, the pouch including: (a) a first polymeric sheet including a first inner body and a first outer surface, the first inner body including a first inner surface and inner microstructure extending from the first inner surface, the first inner body defining an aerial microstructure surface area density (AMSAD) between 5% and 15%; (b) a second polymeric sheet including a second inner surface and a second outer surface. The second polymeric sheet may be joined with the first polymeric sheet such that the first inner body and the second inner surface form an air-tight fluid chamber therebetween. The second polymeric sheet may lack microstructure extending from the second inner surface. The first inner surface, the first outer surface, the second inner surface, and the second outer surface may be smooth and non-recessed.

Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle.