Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

A method of making a solvent cast polymer composite film comprising (a) contacting barium titanate, a titanate coupling agent (TCA) and a mixing solvent to form a barium titanate and TCA solution; (b) dispersing at least a portion of the barium titanate and TCA solution to form TCA treated barium titanate; (c) contacting at least a portion of the TCA treated barium titanate with a polyetherimide and a casting solvent to form a polymer composite casting solution; (d) casting at least a portion of the polymer composite casting solution onto a casting substrate to form a solvent cast polymer composite solution; and (e) curing at least a portion of the solvent cast polymer composite solution to form the solvent cast polymer composite film.

A method of making a solvent cast polymer composite film comprising (a) contacting barium titanate, a titanate coupling agent (TCA) and a mixing solvent to form a barium titanate and TCA solution; (b) dispersing at least a portion of the barium titanate and TCA solution to form TCA treated barium titanate; (c) contacting at least a portion of the TCA treated barium titanate with a polyetherimide and a casting solvent to form a polymer composite casting solution; (d) casting at least a portion of the polymer composite casting solution onto a casting substrate to form a solvent cast polymer composite solution; and (e) curing at least a portion of the solvent cast polymer composite solution to form the solvent cast polymer composite film.

Disclosed are a negative pressure driven sucking apparatus and a preparation method thereof. The sucking apparatus comprises a sucking disc body, wherein a negative pressure cavity is formed in the middle of the sucking disc body, and the negative pressure cavity is connected with a vacuum line, and the bottom of the negative pressure cavity having a flexible section, and an annular wedge-shaped microstructure is formed at the bottom of the body surrounding the flexible section. Stable loading and release processes of the annular wedge-shaped microstructure are realized.

A method of spacing an object from a mould for the formation of a multi-layered polymer. The method comprises: attaching at least one spacer to the object; attaching the at least one spacer to the mould; and adding material to the mould to form the multi-layered polymer.

Embodiments of the microfluidic device may include of an array of microfluidic cell capture chambers, each functionalized with a different antibody to recognize a target antigen, and a network of code-multiplexed Coulter counters placed at strategic nodes across the device to quantify the fraction of cell population captured in each microfluidic chamber. For example, an apparatus may comprise a fluid inlet port divided into a plurality of separate microfluidic paths, each separate microfluidic path configured to transport a plurality of cells, the plurality of separate microfluidic paths, each comprising a plurality of microfluidic cell capture chambers, an outlet port to discharge a merged output of cells from the plurality of microfluidic cell capture chambers, and a plurality of sensors to detect cells passing into or out of a microfluidic cell capture chamber.

Embodiments of the microfluidic device may include of an array of microfluidic cell capture chambers, each functionalized with a different antibody to recognize a target antigen, and a network of code-multiplexed Coulter counters placed at strategic nodes across the device to quantify the fraction of cell population captured in each microfluidic chamber. For example, an apparatus may comprise a fluid inlet port divided into a plurality of separate microfluidic paths, each separate microfluidic path configured to transport a plurality of cells, the plurality of separate microfluidic paths, each comprising a plurality of microfluidic cell capture chambers, an outlet port to discharge a merged output of cells from the plurality of microfluidic cell capture chambers, and a plurality of sensors to detect cells passing into or out of a microfluidic cell capture chamber.

The present invention relates to a mould (1) for kids for making jewelry from a granular water-sensitive product, comprising: —a hollow body (2) having an opening (3) defining a respective forming zone; —a first element (4) combined with the hollow body (2) for closing-opening the opening (3) at a first side of the forming zone; —a second element (5) combined with the hollow body (2) for closing, and possibly opening, the opening (3) at a second side of the forming zone; wherein at least one among the hollow body (2), the first element (4) and the second element (5) comprises a plurality of holes (6) which are open in the forming zone, such that the forming zone is fluidically communicating with the environment outside of the mould (1).

The present invention relates to a mould (1) for kids for making jewelry from a granular water-sensitive product, comprising: —a hollow body (2) having an opening (3) defining a respective forming zone; —a first element (4) combined with the hollow body (2) for closing-opening the opening (3) at a first side of the forming zone; —a second element (5) combined with the hollow body (2) for closing, and possibly opening, the opening (3) at a second side of the forming zone; wherein at least one among the hollow body (2), the first element (4) and the second element (5) comprises a plurality of holes (6) which are open in the forming zone, such that the forming zone is fluidically communicating with the environment outside of the mould (1).

A resin molding method is capable of reducing the use amount of micropellets and obtaining a resin molded article having required characteristics. A resin molding method includes a disposing step of disposing a preliminary molded body laminated and formed in a three-dimensional shape in a molding die, a filling step of heating and melting the preliminary molded body by an electromagnetic wave transmitted through the molding die and filling the molding die with a molten resin material, and a cooling step of cooling and solidifying the molten resin material in the molding die. In the cooling step, a resin molded article integrated so as to eliminate a lamination interface of the preliminary molded body is formed in the molding die.