Simulated tissue structures for practicing surgical techniques and methods of manufacturing those structures are provided. In particular, a realistic organ model or simulated tissue portion for practicing the removal of a tumor or other undesired tissue followed by suturing a remnant defect as part of the same surgical procedure is provided. The simulated tissue structures include a polyp simulation having a suturable mesh layer that is separable from a defect layer. A simulated colon model with interchangeable and suturable tissue pods is also provided as is a fully suturable rectum model and a rectum model with integrative suturable and removable polyp zones.

A method for making a biocompatible three-dimensional heart valve includes delivering, using at least one delivery unit, a biocompatible fluid substance towards a mold having a mold surface to obtain a coating layer of predetermined thickness that coats the mold surface, where the biocompatible fluid substance includes a plurality of particles; handling the mold and the delivery unit to provide a relative movement with at least three degrees of freedom between the mold and the delivery unit, the mold coated with the biocompatible fluid substance that is delivered to obtain a three-dimensional heart valve having a surface corresponding to the mold surface; removing, using a suction and blowing device, from the mold any surplus particles of the biocompatible fluid substance dispensed to make uniform the predetermined thickness of the coating layer; and pressing a counter mold on the coating layer deposited on the mold after delivering the biocompatible fluid substance.

A method for making a biocompatible three-dimensional heart valve includes delivering, using at least one delivery unit, a biocompatible fluid substance towards a mold having a mold surface to obtain a coating layer of predetermined thickness that coats the mold surface, where the biocompatible fluid substance includes a plurality of particles; handling the mold and the delivery unit to provide a relative movement with at least three degrees of freedom between the mold and the delivery unit, the mold coated with the biocompatible fluid substance that is delivered to obtain a three-dimensional heart valve having a surface corresponding to the mold surface; removing, using a suction and blowing device, from the mold any surplus particles of the biocompatible fluid substance dispensed to make uniform the predetermined thickness of the coating layer; and pressing a counter mold on the coating layer deposited on the mold after delivering the biocompatible fluid substance.

A needle-like structure includes projections formed in rows on a substrate and extended in a direction, and needle portions formed on each of the projections such that the needle portions are spaced part from one another.

A large-area monolayer of solvent dispersed nanomaterials and method of producing same is provided. The method includes dripping a nanomaterial solvent into a container filled with water whereby the nanomaterial being dripped collects at the air-water interface to produce the large-area monolayer. In one embodiment, different nanomaterial solvents can be dripped, at predetermined intervals such that the resulting large-area monolayer includes at least two different nanomaterials.

A large-area monolayer of solvent dispersed nanomaterials and method of producing same is provided. The method includes dripping a nanomaterial solvent into a container filled with water whereby the nanomaterial being dripped collects at the air-water interface to produce the large-area monolayer. In one embodiment, different nanomaterial solvents can be dripped, at predetermined intervals such that the resulting large-area monolayer includes at least two different nanomaterials.

A method for forming a building includes obtaining a mould, spraying a first spray material onto the outside of the mould so that it sets generally in the shape of the mould to provide a core. The core has side walls, and end wall integral with the side walls and a roof integral with both the side walls and end wall. A second spray material different to the first spray material is sprayed onto the inner and outer surfaces of the core to give it a rigid skin.

A method for forming a building includes obtaining a mould, spraying a first spray material onto the outside of the mould so that it sets generally in the shape of the mould to provide a core. The core has side walls, and end wall integral with the side walls and a roof integral with both the side walls and end wall. A second spray material different to the first spray material is sprayed onto the inner and outer surfaces of the core to give it a rigid skin.

Disclosed is a method for manufacturing a flexible three-dimensional structure, characterised in that it includes the following steps: preparing a temporary mould defined by a peripheral surface; positioning a support structure on at least one portion of the peripheral surface of the temporary mould; decomposing the temporary mould; and extracting the decomposed temporary mould.

Disclosed is a method for manufacturing a flexible three-dimensional structure, characterised in that it includes the following steps: preparing a temporary mould defined by a peripheral surface; positioning a support structure on at least one portion of the peripheral surface of the temporary mould; decomposing the temporary mould; and extracting the decomposed temporary mould.