Disclosed is a needle-free applicator that is suitable for administering a solid, amorphous, mono-particulate powder composition into a body cavity of a human patient, which cavity includes a mucosal surface, wherein the applicator comprises: (i) an opaque reservoir comprising said powder composition; (ii) an optional actuating means for generating a force upon actuation of the device by a user; and (iii)a dispensing means through which, following said actuation, said powder composition may be dispensed, wherein said powder composition comprises a pharmacologically-effective dosage amount of an adrenergic receptor modulator, or a pharmaceutically-acceptable salt thereof, encapsulated in an amorphous state along with a pharmaceutically-acceptable carrier material; and which powder composition is less than about 4% chemically degraded after storage for: (a) at least about 3 months at 40° C. and 75% relative humidity; and/or (b) at least about 18 months at below about 30° C.; and/or (c) at least about 18 hours at above about 1 million lux of UV light.

The invention provides a unit dose dispenser in the form of a blister containing a dry powder for inhalation. The blister comprises a base material in which a cavity is formed comprising a bowl that contains the powder and a channel that opens into the bowl. The channel contains a tube that has separate sections that provide an air outlet and an air inlet. The air outlet is further from the bowl than the air inlet. The upper side of the tube is flat and level with the top of the channel A lid material, such as a foil or foil laminate, seals the cavity. The blister has a detachable portion which, when removed, exposes the air inlet and the air outlet. A process for making the unit dose dispensers is also provided, which is based on the conventional process for manufacturing blister strips for dry powder inhalers.

A method of delivering a substance, such as fluticasone propionate, a nasal steroid and/or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of sinus and/or nasal inflammatory diseases, for example, chronic rhinosinusitis with or without nasal polyps, to reduce sinus inflammation, reduce sinus opacification, and/or improve associated symptoms.

Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient.

A vaporizing article, comprises a vaporizer drive circuit; one or more memories configured to store a percentage of at least one constituent in an inhalation media, one or more compensation values for at least one compensation category for the at least one constituent, and instructions; and a control circuit comprising a processor coupled with the one or more memories configured to run the instructions, the instructions configured to cause the processor to: receive a dose target for a constituent; determine whether to perform compensation for an inhalation media dose in order to ensure the dose target is met; when compensation is to be performed, determine the properly compensated inhalation media dose based on an associated compensation value for the constituent; and control the vaporizer drive circuit so as to dispense a compensated dose of the inhalation media.

Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed.

A nasal powder dispenser device (100) having a reservoir (110) containing a dose of powder; a nasal dispenser head (120) for inserting into a user's nostril, the nasal dispenser head including a dispenser orifice (121); and an air expeller (130) that, during actuation of the nasal powder dispenser device (100), generates a flow of compressed air so as to dispense a dose of powder into the nostril through the dispenser orifice (121). The air expeller has an air chamber (131) and a piston (132) that slides in airtight manner in the air chamber (131) so as to compress the air contained in the air chamber (131); the nasal powder dispenser device (100) presenting the following properties: a pressure, of the flow of compressed air generated by the air expeller (130), that is higher than 0.7 bar; and a volume, of the air chamber (131), that is greater than 1700 mm.sup.3.

An article for use with an apparatus for heating aerosol generating agent to volatilize at least one component of the aerosol generating agent, the article including a support layer having a first surface, wherein at least a portion of the first surface is rough and an aerosol generating agent on the portion of the first surface that is rough.

A vaporizer device may include a controller and a heater control circuitry. The controller may generate, based at least on a temperature of a heating coil in a cartridge coupled with the vaporizer device, an output signal for controlling a discharge of a battery of the vaporizer device. The battery may be discharged to the heating coil to increase the temperature of the heating coil and cause a vaporization of a vaporizable material contained in the cartridge. The heater control circuitry may determine the temperature of the heating coil. The heater control circuitry may further control, based on the output signal from the controller, the discharge of the battery to the heating coil. The heater control circuitry may be powered by a voltage rail coupled to a voltage regulator configured to regulate an output voltage of the battery.

The present disclosure provides an aerosol delivery device and a cartridge for an aerosol delivery device. In various implementations, the cartridge may comprise a housing defining a liquid reservoir, an atomizer configured to produce an aerosol, the atomizer comprising a first liquid transport element, a second liquid transport element, and a microvalve located between the liquid reservoir and the second liquid transport element. The microvalve may comprise a base member including at least one channel, and an actuating member at least a portion of which comprises a shape-memory material, and which is configured to move between a first position and a second position, wherein in the first position, the actuating member substantially blocks fluid flow from the liquid reservoir through the channel, and in the second position, the actuating member allows fluid flow from the liquid reservoir through the channel and to the second liquid transport element.