Kits enabling an end user to efficiently compound inhalable formulations containing medicinal compounds, for use in in aerosol device (e-cigarette; personal vaporizer). Kits include a reusable storage device, a filling station, at least one predetermined amount aerosol precursor in a container and at least one empty cartomizer (cartridge) for use in an aerosol delivery device. Optionally, kits may also include a predetermined amount of extract containing a known amount of medicinal compound, enabling the production of an amount an inhalable formulation. Optionally, kits may contain amounts of inputs that enable the refilling/reuse of cartridges.

A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives, powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.

The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.

Dispenser, comprising a reservoir (10) containing fluid product, a head (20) provided with an opening (21), a piston (50) for dispensing at least one portion of the fluid product through the opening (21), the reservoir (10) being, before the dispenser is actuated, closed in sealed manner by the piston (50), the device comprising a hollow insert (60) inserted and fixed in the head (20), the insert (60) supporting a cannula (40) for piercing the piston (50) and thus connecting the container (10) to the opening (21) during actuation, wherein:

said dispenser head (20) includes a proximal end portion (220) of reduced diameter the axial length of which is greater than 5 mm, advantageously greater than 6 mm, the maximum outside diameter of which is less than 8 mm, advantageously less than 7 mm, and the wall thickness of which is less than 1.1 mm, advantageously between 0.7 and 1.0 mm;

said dispenser head (20) comprises an inner side wall comprising a first proximal cylindrical section (25) and a second distal cylindrical section (26) of diameter greater than that of said first proximal cylindrical section (25), said insert (60) comprising on its outer wall a first proximal radial projection (65) extending over the entire periphery, said first proximal radial projection (65) cooperating in a tight and sealed manner with said first proximal cylindrical section (25), in order to ensure the sealed fixing of said insert (60) in said dispenser head (20).

Exemplary dry powder inhaler devices may include a housing body having a medicine capsule recess therein, a pair of air inlets each fluidically connecting to the recess, and an outlet body coupled to the housing body. Each inlet may have a width no greater than 1.17 mm. The outlet body may have a channel fluidically connecting the recess to an opening and configured to allow a user to draw air through the opening, thereby allowing an airstream to be drawn through the air inlets, into the housing body recess where it causes the capsule to spin and eject its contents into the airstream, and through the outlet body channel and opening to deliver the substance into the user's lungs. Dry powder respirable drug blend formulations, methods of manufacturing the formulations and drug/device combinations are also provided.

Provided is a blister pack for a dry powder inhaler configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments.

A technique which, while avoiding excessive conduction of heat to the flavor source, reduces variance of heat conduction, and which makes it possible to reduce the weight and the cost of the flavor inhaler is disclosed. A flavor inhaler which, provided with a cylindrical holding member extending along a prescribed direction from a lighting end to a non-lighting end, includes a combustion-type heat source disposed at the lighting end, a flavor source which, in the prescribed direction, is arranged towards the non-lighting end with respect to the combustion-type heat source, and a cup-shape cup member which holds the flavor source and has a side wall and a bottom plate. The cup member is arranged with the bottom plate thereof disposed towards the non-lighting end with respect to the combustion-type heat source, and is inserted into the holding member oriented so as to open towards the lighting end or oriented so as to open towards the non-lighting end, and at least the side wall and the bottom plate configuring the cup member are configured from a material containing pulp, a binder and a metal soap.

A nasal delivery device for a powder, having a reservoir, a delivery head and an air discharge system generating a flow of compressed air. The air discharge system has an air chamber, formed by a hollow axial cylinder, and a piston that sealingly slides in the air chamber to compress the air. The hollow axial cylinder has a radial shoulder connecting a first cylinder portion and a second cylinder portion. Before actuation, the piston is at the first cylinder portions and, during actuation, the piston sealingly cooperates with the second cylinder portion. The radial shoulder defines a profile that the piston overcomes at start of actuation. The piston has an upper lip and a lower lip, a skirt around the hollow axial cylinder with a lower flange projecting radially inward. The skirt has a profile radially projecting towards the inside, cooperating before actuation with the lower lip of the piston.

In general, drug administration devices configured to communicate with networks and external devices are provided. In an exemplary embodiment, a drug administration device is configured to adjust an operational parameter of the drug administration device based on a data packet formed from drug administration data ancillary data received from networks and/or external devices. In another example embodiment, a drug administration device is configured to scan for and establish communications with at least one external device. In another example embodiment, a method includes assessing whether to update a control program on a drug administration device from a network or external device. In another example embodiment, a system includes a first drug administration device configured to communicate with a second drug administration device to optimize a drug treatment.