A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

A small form factor metered dose inhaler is disclosed. The inhaler includes a casing having a longitudinal axis and a transverse axis. The casing has a mouthpiece opening at one end along the longitudinal axis. The casing is configured to house a medicament canister along the longitudinal axis. The medicament canister contains a plurality of doses of a pulmonary medicament and a metered dose valve configured to release a metered dose of the pulmonary medicament through the mouthpiece opening along the longitudinal axis. A mechanical linkage translates an applied input force to the mechanical linkage into an output force along the longitudinal axis configured to actuate the metered dose valve and release the metered dose of the pulmonary medicament in a direction along the longitudinal axis. The aerosolized medicament exits the casing in a fluid flow which is symmetric in a vertical plane along the longitudinal axis.

The present invention is a fluid dispensing apparatus, and method of use, e.g. for mouthwash and medicine, for dispensing a sterile liquid in single doses to prevent bacterial growth from un-used portions pored back into the apparatus. The apparatus has a hollow flexible cap enclosure surrounding a one-way valve inside of a bladder and a push rubber surface for liquid release. When the cap is removed, both the container body and the cap remain sealed from exposure to contaminates. Liquid is first dispensed from the container by inverting the container until a quantity of sterile liquid collects in the cap. The container is then positioned in an upright position and the fluid filled cap is removed from the container. The cap is then inverted again and a pushbutton pressed to dispense sterile liquid from a cap spray nozzle without requiring the user's lips to touch the cap.

An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister. The canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall. The canister housing has a longitudinal axis X which passes through the center of the central outlet port. The first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler.

The present invention provides dry powder inhaler (DPI) devices (100) for dispensing dry powder and methods for using the same. The DPI devices feature vortex mechanisms for directing air in a turbulent manner sufficient to entrain an amount of a dry powder dose for delivery into a user's lungs. The DPI devices feature replaceable dry powder cartridges (200). The DPI devices also feature a retractable configuration for storage and for accidental dispensing of dry powder. The DPI devices dispense dry powder in controlled dosages.

A drug delivery device, in particular a nebulizer or inhaler, for dispensing a fluid includes a cartridge having a collapsible container within which the fluid is disposed, a mechanism to help the collapsing process and to prevent the collapsed container from expanding again, hence preventing the forming of vapor and gas bubbles within, where the mechanism is adapted to pressurize the fluid within the container during withdrawal of the fluid.

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Aspects and embodiments of the present invention generally include a device for patient self-administration of a prescribed medication. The total quantity of doses to be contained in the device, the quantity of prescribed medication comprising each individual dose, and the dosing schedule, collectively referred to as prescription parameters, are determined and controlled solely by a health care provider. In accordance with a prescribed dosing schedule, the device makes available for administration the precise quantity of prescribed medication constituting an individual dose. Patient access to the medication as well as patient control of the device is limited solely to the aspects of the device necessary to administer the available dose. The device also has a monitored subassembly which detects and transmits relevant device information to a remote management system accessible to the HCP, including detected attempts to alter, access, control or otherwise tamper with the device beyond its prescribed use.

Provided is a system comprising an inhaler. The inhaler comprises a use determination system. The use determination system is configured to determine a parameter relating to airflow during a use of the inhaler by a subject. The use determination system also assigns a time to the use. The system also comprises a user interface, and a processing module. The processing module is configured to determine inhalation information from the parameter, and control the user interface to issue a notification that the inhalation information is available. The notification is issued at a notification time. The processing module is configured to implement a deliberate time delay such that the notification time is delayed relative to the time assigned to the use.

A gas-evolving composition delivery system is disclosed, which comprises a pressurized container having a dispenser, and a liquid gas-evolving composition, such as an acidified nitrite solution, within the pressurized container, wherein the pressurized container has an internal pressure sufficient to minimize gas production from the gas-evolving composition while within the container. Also disclosed is a method of stabilizing an acidified nitrite solution comprising loading the solution into a container and sealing the container to be airtight.