Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user.

An aerosol generator with electrical power conducting pins has a vibratable plate with apertures therein and an annular piezo. An annular support member supports the piezo and the vibratable plate. A first electrical power conducting pin engages directly with a first, top, surface of the piezo. A second electrical power conducting pin indirectly conducts electrical power to a second surface of the piezo, by contacting an extension tab. There is a film of cured epoxy adhesive on the tab. The aerosol generator avoids need for soldered joints for electrical contact, and the pins are conveniently mounted parallel to each on the same lateral and top side of the piezo and support member. The pins may have multi-point tips for particularly effective electrical contact.

A method for functional testing of aerosol provision devices may include performing a functional state transition test of a power unit. The functional state transition test of the power unit may include extracting a unique identifier from the power unit of an aerosol provision device responsive to operable coupling of the power unit to a test fixture, determining a transition code based on the unique identifier, providing the transition code to the power unit via the test fixture to transition the power unit from an initial state to a transitioned state, and transitioning the power unit to the initial state.

The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.

An aperture plate is manufactured by plating metal around a mask of resist columns having a desired size, pitch, and profile, which yields a wafer about 60 μm thickness. This is approximately the full desired target aperture plate thickness. The plating is continued so that the metal overlies the top surfaces of the columns until the desired apertures are achieved. This needs only one masking/plating cycle to achieve the desired plate thickness. Also, the plate has passageways formed beneath the apertures, formed as an integral part of the method, by mask material removal. These are suitable for entrainment of aerosolized droplets exiting the apertures.

Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.

Antiseptic agent delivery systems and methods are provided, one such system comprising: a reservoir configured to store an antiseptic solution, wherein the antiseptic solution comprises an aqueous solution of hypochlorous acid; an ultrasound generator coupled to the reservoir, wherein the ultrasound generator vaporizes the antiseptic solution into an antiseptic vapor; a nozzle to direct the antiseptic vapor to an affected area; and a housing coupled to the reservoir and the nozzle, wherein the housing comprises a panel to control the ultrasound generator.

A power supply unit of an aerosol generating device includes: an accommodating portion with a bottom and cylindrical shape, which is configured to accommodate a columnar cartridge that stores an aerosol source in a state in which the cartridge is rotatable 360 degrees in a circumferential direction of the cartridge. A rotation suppressing portion configured to generate a frictional force between the cartridge and the rotation preventing portion so as to suppress rotation of the cartridge in the circumferential direction is provided on a bottom portion of the accommodating portion.

An electronic device for producing an aerosol for inhalation has a mouthpiece and an elongate housing. The mouthpiece attaches to an upper end of the housing. The housing contains a liquid container and a mesh assembly with mesh material that vibrates when actuated for aerosolizing liquid from the container. The mouthpiece covers the mesh assembly at the upper end of the housing, and the aerosol produced by the mesh assembly may be inhaled through the mouthpiece by a person. The housing contains circuitry and a power supply, preferably are located in a lower half of the housing, for actuating vibration of the mesh material. Electrical pathways connect the mesh assembly with the circuitry and power supply. The power supply may comprise one or more batteries located at the lower end of the housing. The aerosol is produced without smoldering of the liquid and without using a compressed gas.

An ultrasonic electronic rhinitis therapeutic apparatus with far-infrared atomized coconut essential oil is disclosed. The apparatus includes a nasal plug part and a nasal alar part. The nasal plug part includes an insertion column disposed in a nostril. The insertion column is internally provided with a coconut powder, and a far-infrared generating tube is arranged in the coconut powder. An ultrasonic generator is arranged in the nasal alar part, and the nasal alar part is fitted on the lateral side of the nasal alar. In the disclosure, the oil and acid substance in the coconut powder are atomized by far-infrared light and are atomized under the aid of pulse ultrasonic wave in the nasal cavity to be inhaled into the internal tissues of the nasal cavity, sinus and the like.