A breath-enhanced nebulizer adapted for use in administering an aerosolized pharmaceutical composition to a patient by inhalation wherein the patient is connected to a mechanical ventilator is disclosed. The nebulizer has a Venturi driven by a nebulizer air supply that draws a solution of a pharmaceutical composition into a shear zone where the solution is atomized. The Venturi effect is amplified by the internal configuration of the nebulizer to increase the rate of nebulization of drug. Optionally, breath-actuated nebulization is used, employing a pressure sensor interposed between the nebulizer and mechanical ventilator that controls the nebulizer air supply, such that nebulizer air and concomitant nebulization only occurs during the inhalation phase of a breathing cycle.

A stable dry powder composition for inhalation includes acetylsalicylic acid in particles having a mass median aerodynamic diameter (MMAD) in a range of about 1 μm to about 5 μm. The dry powder composition may contain a pharmaceutically acceptable excipient, such as a stearate, in an amount ranging from about 0.04% (w/w) to about 0.06% (w/w), or from about 0.4% (w/w) to about 0.6% (w/w), of the composition.

An atomizer is provided. The atomizer includes a battery rod, including a rod body, a battery, and a first electrical connection part arranged on the rod body and exposed from the rod body, wherein an end of the rod body is disposed with a receiving part, and the first electrical connection part is located in the receiving part, an atomizing head, including a housing and a second electrical connection part arranged on the housing and exposed from the housing, and a mechanical switch, arranged on the rod body and exposed outside the rod body, wherein the mechanical switch is electrically connected between the battery and the first electrical connection part, and configured to turn on or turn off an electrical connection between the battery and the first electrical connection part; wherein the first electrical connection part is in contact with the second electrical connection part when the atomizing head is inserted into the receiving part, the electrical connection between the battery and the first electrical connection part is turned on when the atomizing head is inserted into the receiving part and the mechanical switch is triggered, and thereby an electrical connection between the first electrical connection part and the second electrical connection part is turned on to supply a power to the atomizing head through the battery. Using the mechanical switch to control the battery rod whether supply a power to the atomizing head or not can ensure the effectiveness of triggering power supply for a long time.

A dispensing apparatus is for use by users to take a chamber, fill the chamber with an aerosolized vaccine or other medicament, and dispose of used chambers. A display provides instructions to encourage prompt inhalation by the user from a dispensed and filled chamber. The apparatus allows very fast administration of vaccines to large numbers of people. The aerosol dispenser apparatus detects the chamber is in correct position and delivers a pre-determined dose of aerosol. Once the dose is delivered a visual and/or audible indicator informs the user that the chamber is filled and that they can take the inhalation. The single dose aerosol chamber is optimized for efficient administration of an aerosol.

This invention provides a budesonide/formoterol dry powder inhaler (10) comprising: a reservoir (14) containing a dry powder medicament and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator (10′) for breaking up agglomerates of the dry powder medicament; a delivery passageway (34) for directing an inhalation-induced air flow through a mouthpiece (24), the delivery passageway extending to the metered dose of medicament, wherein the medicament comprises micronised formoterol fumarate, micronised budesonide and a lactose carrier, the lactose carrier having a particle size distribution of d10=20-65 μm, d50=80-120 μm, d90=130-180 μm and <10 μm=<10%.

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

An aerosol generating device, includes an inhalation outlet; a chamber for holding a material, the material capable of generating a vapour when heated; a heater for heating material held in the chamber; an air inlet connected by an air inlet passage to the chamber; a vapour-cooling module providing a fluidic connection between the chamber and inhalation outlet, the module configured to cool a vapour passing there through. Suction at the inhalation outlet causes air to enter the chamber via the air inlet, thereby transporting vapour generated in the chamber through the module to the inhalation outlet, such that the temperature of the vapour exiting the device through the inhalation outlet is substantially lower than the temperature of the vapour generated in the chamber. The device thereby provides a means whereby a vapour generated in the chamber is substantially cooled during transport from the chamber through the mouthpiece to the user.

A modular electronic inhaler having an embedded system and a method for precise and repeatable delivery of multiple types of medications in different forms to the pulmonary system of a human user. The inhaler can include a first MDI housing defining an internal chamber for accommodating a MDI medication cartridge and a second DPI housing defining an internal chamber for accommodating a DPI medication cartridge. Meter reservoir compartments in each housing can automatically provide precise doses of medicine using vacuum pressure sensors. The sensors can be in communication with the internal embedded system/electronics (microcontroller) of the inhaler and the electronics/microcontroller can be in permanent communication with a software application running on the user's smart phone or other electronic device.

A therapeutic device for treating one or more conditions associated with a user's nasal cavities, sinuses, and/or ear canals includes a vibration generator having an acoustic device operable to provide a sound; a seal configured to cover a nose, but not a mouth, of the user to form an air-tight chamber around the nose of the user; the vibration generator disposed in a housing connected to the seal; and a stand extending from the housing and including a ball bearing and a seat on which the ball bearing may rest, the stand including a hollow member and an orifice, the orifice disposed in the seat. The vibration generator provides the sound directly to the nose of the user. A positive pressure is created in the air-tight chamber when the user exhales, the positive pressure generating a lift force to lift the ball bearing from the seat.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.