Dispensing systems for a ventilator circuit having a ventilator flow circuit with a normal inhalation flow path with a heat and moisture exchanger (HME), a flow sensor in communication with the ventilator circuit, an automated drug dispensing system with an actuator and a pressurized canister residing upstream of the HME, a bypass inhalation flow path residing downstream of the pressurized canister, and at least one electromechanical valve residing in the inhalation flow path to selectively open the valve which can be normally closed to define a closed bypass path. At least one controller opens the at least one electromechanical valve to open the bypass inhalation flow path and close the normal inhalation flow path through the HME only when the flow sensor indicates air flow is in an inhalation direction. Once the valve is open, the actuator dispenses medication through the bypass inhalation flow path to the patient.

A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.

An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece, a liquid container, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the container. The mesh material is configured to vibrate when the piezoelectric material is actuated, whereby the aerosol is produced. The aerosol may be inhaled through the mouthpiece. The device also includes circuitry and a power supply for actuating the mesh assembly. The mouthpiece, the container, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the container. The mesh material has a rigidity that is sufficient to prevent oscillations of varying amplitudes during actuation of the piezoelectric material of the mesh assembly for consistently producing the aerosol.

A system for delivering a composition containing a nutritional supplement matrix to a user through the oral mucosa, in which the matrix is held under pressure in a canister that has a nozzle with at least one rotating internal member positioned between the canister outlet and the nozzle outlet, in which the rotating member agitates the composition to increase atomization to aid in absorption.

A water bottle with a pressurized compartment and an unpressurized compartment to integrate supplemental oxygen delivery into a hydration and electrolyte management system. The unpressurized compartment may be manually filled with a fluid. The user may consume fluid from the unpressurized compartment and an aerosol from the pressurized compartment independently or simultaneously.

Disclosed is an oral mucosa delivery system that allows a composition housed therein to be dispensed in different amount and/or for different duration. The delivery system may comprise a spray cap or an aerosol cap capable of controlling the delivery duration and/or amount by a mechanical or electronic means.

The present invention provides a system, a kit and a use thereof for oral mucosa delivery of a composition. The composition may comprise at least two sub-compositions admixed right before dispensing to the oral mucosa. In one embodiment, the system is a pressurized system. In another embodiment, the admixed sub-compositions are atomized. In one embodiment, one of the sub-compositions comprise a beneficiary gas, such as oxygen. In another embodiment, one of the sub-compositions comprise a nutritional supplement, a nutraceutical composition, a pharmaceutical composition, or any combinations thereof.

A device for delivering a predetermined amount of at least one substance to a body orifice of a subject includes a) a container for containing said at least one substance; b) a delivery end for placement in proximity to the orifice, the delivery end being in fluid communication with the container; c) a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d) a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; and e) a fluid tight chamber.

The present invention comprises a compact atomizer that substantially encapsulates a standard inhalant canister and allows for in-line dispensing through a mouthpiece formed in an actuating cover. The compact atomizer comprises an actuating cover and housing that cooperate to secure the canister. By compressing the actuating cover and housing together, a nozzle of the canister is depressed to release a portion of substance within the canister. Compression is enabled by an actuation surface formed in the actuating cover. Substance is released in-line with the canister through a mouthpiece at the end of the actuating cover. The result is a small, compact, yet attractive atomizer that can be carried in a pocket or the like while keeping the canister free of debris.

A system and method for automatically delivering a substance to an animal or fish including a positioning system that positions each animal singularly and a sensor that detects the location of a predetermined targeted area on the animal. The system further includes a delivery device for delivering a substance to the targeted area. The position of the delivery device may be adjustable. The delivery device is in communication with the sensor. The delivery device adjusts its position in response to the data received from the sensor and delivers a substance to the targeted area.