In general, drug administration devices configured to communicate with networks and external devices are provided. In an exemplary embodiment, a drug administration device is configured to adjust an operational parameter of the drug administration device based on a data packet formed from drug administration data ancillary data received from networks and/or external devices. In another example embodiment, a drug administration device is configured to scan for and establish communications with at least one external device. In another example embodiment, a method includes assessing whether to update a control program on a drug administration device from a network or external device. In another example embodiment, a system includes a first drug administration device configured to communicate with a second drug administration device to optimize a drug treatment.

A system and method for measuring the effectiveness of a dose from an inhaler on a user is disclosed. The inhaler includes a drug container and a dosing mechanism coupled to the drug container to aerate a dose from the drug container. The dosing mechanism provides the aerated dose to the user. A sensor interface is in communication with a physiological sensor. The physiological sensor is attached to a user to sense a physiological response to the dose. Physiological data is sent to the sensor interface. A controller is coupled to the sensor interface to collect the sensed physiological data from the user corresponding to the time that the aerated dose is delivered to the user. The effectiveness of the dose may be determined from the collected data. The dose amount or frequency may be changed or the drug may be changed based on the collected data.

An inhaler (10) for the inhalation of inhalable substances comprise: a canister (50) having an interior reservoir (84) containing pressurised inhalable substances including fluid; a metering valve (52) including a metering chamber (82) and a valve stem (54) defining a communication path between the metering chamber and the interior reservoir, the communication path (86) including an opening (106) configured to permit flow between a transfer space inside the valve stem and the interior reservoir, the interior reservoir being arranged for orientation above the metering chamber whereby gas such as air located within the metering chamber is replaced with liquid from the interior reservoir.

Systems and methods for monitoring accurate, real-time medicament device events, performing analytics on that data, and providing notifications are described. In various embodiments, an application server receives controller medication events, analyzes the events, associated event times, and controller medication dosage plans to characterize event times and send notifications for future doses. The controller medication dosage plan may specify a dose time for a planned dose, a narrow time window comprising the dose time, and an expanded time window comprising the narrow time window and longer in duration than the narrow time window, and the events may be characterized based on their time relative to the dose time, the time windows, and other events.

A refill assembly configured to be removably coupled to a reusable assembly of a medicinal inhaler is disclosed and includes a patient port, a canister actuable by the reusable assembly to deliver a dose of medicament to the patient port, and a sleeve which is selectively actuable by a user independently of the reusable assembly so as to act on the canister to deliver a dose of medicament. The refill assembly further includes an override element which engages the sleeve, the override element being moveable from a first position in which the sleeve is retained in a first position by the override element and a second position in which the sleeve is permitted to move to a second position upon depression of the sleeve by a user to cause a dose of medicament to be delivered to the patient port.

Disclosed is a computer controlled dosage system, for dosage adjustment for a mobile, hand held, inhaler for delivering a dosage of a medicine, is provided. The system comprises at least one measuring device for measuring at least one parameter; and a handheld mobile computer separate from the inhaler, the computer being configured to communicate with the at least one measuring device and with a remote memory for sending and receiving information to and from patient medical records of the remote memory for storage in a memory of the computer, and the computer being configured to receive a manual input for storage in the memory of the computer. The computer is configured to create a data set for setting a plurality of levels of different dosages of medicine based on the medicine used by the inhaler, the information from the patient's medical records of the remote memory, and the manual input; and the computer is further configured to store the data set in the memory of the computer. The computer is further configured to generate an indication indicating a dosage adjustment for the inhaler, based on the at least one parameter and on one of the plurality of levels of dosage of the data set, the indication indicating one of the plurality of levels of dosage of the data set as the dosage adjustment for the inhaler. A dosage regime generated by the computer controlled dosage system is also disclosed.

The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.

A breath-responsive metered dose inhaler having a trigger mechanism for triggering delivery of a medicament and a trigger mechanism chassis for locating the trigger mechanism within the inhaler, the trigger mechanism including a breath responsive member moveable upon inhalation of the user from a primed position in which the inhaler is prevented from delivering medicament, to a triggered position in which the medicament is delivered to the user, a spring which is flexible along its longitudinal axis, wherein the spring is configured to bias the breath responsive member from its triggered position to its primed position by flexure along its longitudinal axis.

A medical double configurational and multiple ports mask preferably including a multifunctional plug with or without a nebulizer oxygen delivery adaptor (“NODA”) attachment. The mask fits over the mouth and the nose and preferably contains at least two possible nose/face configurational solutions. The mask can be secured over the head with a stretchable or non-stretchable material. The position of the preferred triple ports of the double configurational mask provides improved structural construction reflecting different patient's nose/face features and allows for different types of procedures to be performed at the same time regardless of the patient's head/neck position. The multifunctional plug can be used for a variety of applications. The mask can be used with existing standardized disposable respiratory care equipment, including a simplified improved nebulizer oxygen adaptor (“SINODA”) and/or multifunctional use nebulizer oxygen delivery adaptor (“MUNODA”) attachment.

An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.