Dry powder inhaler dose counters capable of making a display move swiftly between digits. In contrast to the progressive movement that occurs in simple gearing mechanisms, there is provided a dry powder inhalation device comprising a housing defining a chamber, a patient port in communication with said chamber, an elongate carrier carrying medicament, an advancement mechanism for advancing a length of the elongate carrier into the chamber, a displacement sensor that advances in association with continuous advancement of the elongate carrier, and a transfer component that converts the advancement of the displacement sensor into intermittent motion of a units dose display.

The invention related to dry powders that contain a therapeutic agent. The dry powders have characterstics, e.g., they are processable and/or dense in therapeutic agent that provide advantages for formulating and delivering therapeutics agents to patients.

The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides particulate powders, such as might be of use for delivery using a dry powder inhaler (DPI) or similar delivery device, having properties which may be beneficial to the DPI delivery process.

The method and system according to preferred embodiments of the present invention allows an effective delivery of aerosolized medicament (e.g., a surfactant) to the patient's lungs. According to a preferred embodiment, the method of the present invention provides an efficient delivery of the aerosol medicament (possibly breath synchronized). A glass vial in which medicaments are usually stored and shipped is used directly as a component of the system. Its function in the system is that of an intermittently pressurized chamber that can inject the surfactant into the catheter of the atomizer device. According to a preferred embodiment the delivery can be done in phase with the beginning of each inspiration. The main elements of the system are: a source of compressed gas, the already mentioned medicament vial, a catheter, and optionally means to detect the breathing pattern and a control unit.

A compliance monitoring module for a breath-actuated inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being pneumatically coupled to a flow channel through which a user can inhale; a processor configured to: receive a signal originating from a dosing mechanism of the inhaler indicating that medication has been released; receive data from a sensing element of the sensor; and based on said signal from said dosing mechanism and said data from said sensing element, make a determination that inhalation of a breath containing medication through said flow channel complies with one or more predetermined requirements for successful dosing; and a transmitter configured to, responsive to said determination, issue a dosing report.

A system and method for providing a therapy to a subject may include a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respired by the subject. A sensor is configured to monitor the lumen and generate a signal based on the air respired by the subject. A pressure pulse delivery system is configured to deliver a pressure pulse along the lumen to the subject and a reservoir of therapeutic agent is coupled to the lumen. A processor is configured to receive the signal from the sensor, determine, from at least the signal, an exhalation period of the subject, and based on the exhalation period, cause the pressure pulse delivery system to deliver a pressure pulse to the subject. Following the pressure pulse, the processor can cause the therapeutic agent to be delivered from the reservoir.

A nebulizer comprises a housing, a closed pressure system, at least one pressure relief mechanism and a nebulization mechanism. The housing comprises a nozzle, and the nozzle comprises an outlet portion and an inlet portion communicated with a pressurized gas source. The closed pressure system comprises at least one gas inlet and a gas outlet. The at least one pressure relief mechanism is disposed on the at least one gas inlet. The nebulization mechanism is capable of moving to a nebulization position. An interior pressure in the closed pressure system is changed by the at least one pressure relief mechanism to control the nebulization mechanism for nebulization.

An inhalation device comprising a housing, a sensor, a microcontroller, and an actuating device controlled by the microcontroller; the housing comprises a mouthpiece having an opening connected to a passage in said housing, wherein the other end of the passage provides an opening for a cartridge; said sensor being in communication with the microprocessor and configured to detect a parameter based on an action to the mouthpiece, and wherein a parameter being reached, the microcontroller engages the actuating device which engages the cartridge to deliver medication through the passage and out of the mouthpiece.

In some embodiments, a system includes a mouthpiece defining a mouthpiece opening, a reservoir configured to contain carrier material, a heating assembly including a heating element configured to apply heat to the carrier material, and a control assembly. The control assembly is configured to receive target temperature data based, at least in part, on an identity of the carrier material contained in the reservoir. The control assembly is further configured to, upon receiving an indication that a user is applying suction to the mouthpiece opening of the mouthpiece, apply a current to the heating element of the heating assembly such that a temperature of the carrier material disposed near the heating element rises to a predetermined temperature based on the target temperature data.

A pulmonary delivery apparatus (10) comprising: a first chamber (15) adapted to thermally vaporise a quantity of a first liquid to form a relatively warm first vapour (B) and a second chamber (16) adapted to atomize a quantity of a second liquid without heating of the second liquid to form a mist of a relatively cold second vapour (A), and an outlet (30) via which, in use, a user can inhale a mixture of the first and second vapours. An active ingredient such as nicotine is provided in the second chamber and an inert liquid in the first chamber.