A refill assembly (129) for use in a medicinal inhaler (100). The refill assembly includes a patient port (110), and an adapter (118) configured to cause a dose of medicament to be released. The adapter is movable between a first position in which a dose of medicament is not released and a second position in which a dose of medicament is released. The refill assembly further includes a lockout mechanism positioned to lock the adapter in its first position, and a lockout override actuator (223). The lockout override actuator is movable between a first position in which the lockout mechanism is in a first locked state, and a second position in which the lockout mechanism is in a second unlocked state and the adapter is movable from its first position to its second position even when the refill assembly is not coupled to a reusable assembly.

A device for delivering medication to a user may include a main body, an electronics module, and a slider. The main body may include a mouthpiece, a medication reservoir, and a mouthpiece cover, where the mouthpiece cover may be hinged to the main body. The electronics module may include a communication circuit, a pressure sensor, and a switch. The slider may be configured to engage the switch when the mouthpiece cover moves from a closed position to an open position. The switch may be configured to switch the electronics module from an off state or a sleep state to an active state. The electronics module may be configured to never return to the off state after the mouthpiece cover is moved to expose the mouthpiece for the first time by the user.

A device having a body (10), a reservoir (100) mounted to slide axially relative to the body, a metering valve (200) on the reservoir (100), a blocking element (500), a trigger element (600), an inhalation-controlled trigger system (60) cooperating with the trigger element, an actuating member (800) cooperating with the blocking element, a cover (11) fixed on the body, a push member (810) fastened tot actuating member (800) and mounted to slide axially in the cover, and a spring (850) between the cover and the push member. Before inhalation, the push member is out of contact with the reservoir, such that the force exerted on the push member by the spring is not transmitted to the reservoir, and during inhalation, the push member moves axially with the actuating member so as to come into contact with the reservoir and move it axially in the body to actuate said valve.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.

According to some embodiments there is provided a device configured for releasing at least one substance from source material, comprising: a housing; a plurality of source material sections positioned at fixed locations with respect to the housing; a plurality of airflow paths, each airflow path associated with at least one source material section; each airflow path associated with at least one blocking element which prevents flow of air through the path; and an actuator operably coupled to the blocking element, the actuator configured for unblocking the airflow path of at least one selected source material section to allow flow of air to and through source material within the selected section.

A dry powder inhaler (1) for pulmonary or nasal use, employing capsules (6) containing a dose of powder for inhalation, comprising four components: a capsule tray (2), a cover (4) and a mouthpiece (8) and an inhaler body (3). Air is drawn by the patient via the mouthpiece (8) which is in communication with the capsule (6) and travels via air paths through the device (1) and through the capsule (6) thereby dispersing and entraining the dose of powder. The capsule (6) is cut by cutting means (18, 19) located on the body (3). The inhaler body (3), the mouthpiece (8) and the cover (4) are provided with hinge segments (20, 35, 42) which when assembled together and the mouthpiece (8) is locked into the body (3), form a single hinge (5) and which allows the cover (4) to freely pivot around the body (3) and the mouthpiece (8).

The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties.

An elongated aerosol-generating device to receive an aerosol-generating article is provided, including: a heater to heat the article, to penetrate an internal portion of article, and extending longitudinally with respect to the device; and an extractor to extract the article received in the device, the extractor being slidable within the device and between an operating position with the heater in contact with the article, and an extraction position with the heater separated from article, the extractor being removable from the device and including a cavity to receive the article, a first aperture defined through an end-wall of the cavity to allow the heater to penetrate the cavity when the extractor is moved between the positions, in which the extractor further defines an air-flow channel to allow air flow into the cavity, an inlet of the air-flow channel being positioned radially-outward of the first aperture.

The invention relates to a device comprising a body (10), a reservoir (100) mounted in an axially slidable manner relative to said body (10), a metering valve (200) assembled on said reservoir (100), said device comprising: —a blocking element (500), —a triggering element (600), —a triggering system controlled by inhalation (60) cooperating with said triggering element (600), and —an actuating member (800) cooperating with said blocking element (500), said device comprising an automatic valve release system which automatically returns said valve (210) of said valve (200) to its rest position after actuation of the valve regardless of the position of said actuating member (800).

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.