A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

A spraying device for producing a spray of particles in a carrier gas at ambient pressure, includes a storage volume for a liquid substance; at least one nozzle having an inlet and an outlet, the nozzle inlet fluidly communicating with the storage volume; a counter electrode; an electric supply coupled between the at least one nozzle and counter electrode for providing a first potential and create a first electric field between the nozzle outlet and the counter electrode. The device further includes at least one discharge electrode coupled to the electric supply for providing a second potential between the discharge electrode and the counter electrode, the polarity of the second potential being opposite to the polarity of the first potential. The at least one nozzle and the at least one discharge electrode are arranged adjacent and parallel to each other and facing the counter electrode from a substantially same direction.

A spraying device for producing a spray of particles in a carrier gas at ambient pressure, includes a storage volume for a liquid substance; at least one nozzle having an inlet and an outlet, the nozzle inlet fluidly communicating with the storage volume; a counter electrode; an electric supply coupled between the at least one nozzle and counter electrode for providing a first potential and create a first electric field between the nozzle outlet and the counter electrode. The device further includes at least one discharge electrode coupled to the electric supply for providing a second potential between the discharge electrode and the counter electrode, the polarity of the second potential being opposite to the polarity of the first potential. The at least one nozzle and the at least one discharge electrode are arranged adjacent and parallel to each other and facing the counter electrode from a substantially same direction.

A system for performing cold atmospheric plasma treatment of respiratory infections or lung cancer having a source of a carrier gas, a cold atmospheric plasma generator connected to the source of carrier gas, a source of compressed air, a humidifier connected to the source of compressed air, a source of oxygen, a ventilator having inputs connected to an output of the humidifier and the source of oxygen, a mixer having an interior chamber formed from a dielectric, an active electrode inside the interior chamber, and an outer electrode connected to ground, wherein the mixer has a fluid input port connected to a gas output of the cold atmospheric plasma generator and an output of the ventilator, and a delivery member connected to an output of the mixer for delivering combined humidified air and cold atmospheric plasma to a respiratory system of a patient.

A method for controlling operation of an inhalation device, comprising configuring an inhalation device to store at least one substance; configuring the inhalation device to dispense the at least one substance in a predetermined manner; configuring the inhalation device to gather usage information about the dispensing of the at least one substance, transmit the gathered usage information to a location or device remote from the inhalation device, and receive operational commands from a location or device remote from the inhalation device, wherein the operational commands are provided by a controller that is in electrical or digital communication with the inhalation device, wherein the controller is configured to both receive usage information from the inhalation device and transmit operational commands back to the inhalation device; and wherein the controller is in electrical or digital communication with a remote server that is configured to receive queries from the controller and transmit information relevant to the queries back to the controller.

A method for controlling operation of an inhalation device, comprising configuring an inhalation device to store at least one substance; configuring the inhalation device to dispense the at least one substance in a predetermined manner; configuring the inhalation device to gather usage information about the dispensing of the at least one substance, transmit the gathered usage information to a location or device remote from the inhalation device, and receive operational commands from a location or device remote from the inhalation device, wherein the operational commands are provided by a controller that is in electrical or digital communication with the inhalation device, wherein the controller is configured to both receive usage information from the inhalation device and transmit operational commands back to the inhalation device; and wherein the controller is in electrical or digital communication with a remote server that is configured to receive queries from the controller and transmit information relevant to the queries back to the controller.

A system includes a nose-to-brain medication delivery device including a medication dispersion device and a magnetic field generator. The generator, when in use, generates a magnetic field of sufficient strength and direction to reposition an ionized and/or magnetized medication to a selected drug delivery site on the brain following initial delivery of the medication from the medication delivery device to the brain cavity via the nose while bypassing the blood-brain barrier.

A portable, hand-held electrospinning or electrospraying apparatus and system, method, and portions thereof, comprised of a durable portion of the hand-held apparatus and a consumable portion of the hand-held apparatus. The consumable portion of the hand-held apparatus, which may contain the solution to be output in electrospin or electrospray fashion, may be replaced in whole or in part to provide additional or alternative solution. A base station may be provided, and can output high voltage and communication signals to the hand-held apparatus to enable the electrospin or electrospray operation by the hand-held apparatus.

A device and method for delivering a fluid as an ejected stream of droplets during inhalation uses inertial filtering to cause a first plurality of droplet particles generated by an ejector mechanism to pass through an airflow exit while a second plurality of droplet particles having a greater mass mean aerodynamic diameter than the first plurality of droplet particles fails to pass through the airflow exit.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.