A container for holding, dispensing and/or storing a preferably liquid medicament preparation is proposed, which comprises an inner space for the medicament preparation and an at least partially multi-layered wall structure defining the inner space, the wall structure comprising a first layer with a first through-opening of less than 40 μm. Alternatively or additionally, the wall structure comprises a second and third layer, a second through-opening being provided in the second layer and the third layer covering or closing off the wall structure.

An applicator can include a dispenser for dispensing an amount of a therapeutic composition, which can include an amount of sugar or sugar alcohol and an amount of an alkalizing agent. In some cases, the alkalizing agent can include L-Arginine. In some cases, 75% or more of the composition by weight has a comedogenicity rating of 3 or less on a scale of 0-5. The dispenser can also have a power supply configured to provide power through a contact tip of the dispenser to provide nerve stimulation, such as using vibration, heating, cooling, and/or electrical stimulation.

A method for analysing a device for spraying a pharmaceutical fluid product including the following steps: providing a spray head of a device for spraying a pharmaceutical fluid product, the spray head having a spray orifice; providing a receiving surface having a plurality of discrete contact zones separated by voids, the contact zones capable of being coated with a heat sensitive material, bringing the receiving surface to a temperature T2, passing a flow of compressed gas through the spray orifice, the flow of compressed gas at a temperature T1 which differs from T2, sending the flow of compressed gas at temperature T1 onto the receiving surface at temperature T2, visualising the impact zone for the flow of compressed gas on the receiving surface, and analysing the visualisation of the impact zone in order to determine whether the spray head complies with predetermined specifications.

A method for analysing a device for spraying a pharmaceutical fluid product including the following steps: providing a spray head of a device for spraying a pharmaceutical fluid product, the spray head having a spray orifice; providing a receiving surface having a plurality of discrete contact zones separated by voids, the contact zones capable of being coated with a heat sensitive material, bringing the receiving surface to a temperature T2, passing a flow of compressed gas through the spray orifice, the flow of compressed gas at a temperature T1 which differs from T2, sending the flow of compressed gas at temperature T1 onto the receiving surface at temperature T2, visualising the impact zone for the flow of compressed gas on the receiving surface, and analysing the visualisation of the impact zone in order to determine whether the spray head complies with predetermined specifications.

Herein disclosed are nasal inserts for treatment and/or management of various different ailments. Easy modification of the insert allows for treatment of various ailments that can readily be treated via the nose. The insert can direct air into or out of the nasal cavity and/or deliver medicinal substances and/or non-medicinal substances to the appropriate regions, thereby providing the appropriate therapeutic effect, depending on the ailment being treated.

The present disclosure relates to a dispenser. Specifically, the dispenser comprises a housing and a stop member fixedly positioned in the housing configured to receive at least a portion of a container and an actuator engagable by a user, whereby contents of the container are released.

The present invention relates to methods of treating neurodegenerative disorders associated with Alzheimer's disease (AD), Parkinson's disease (PD) and synucleinopathies, such as dementia with Lewy bodies, Down Syndrome (DS) and associated cognitive disorders, multiple system atrophy, and rare neuroaxonal dystrophies, such as Niemann-Pick type C disease (NPC) and Gaucher's disease comprising administering an inhibitor to disrupt the interaction between Aβ or αS and neuronal lipids. The invention further relates to assays for identifying agents that reduce interaction between Aβ or αS and neuronal lipids. Lastly, the invention relates to methods and compositions for intranasal administration of fatty acids or lipids containing fatty acid acyl chains of dietary lipids for promoting central nervous system health and/or prevention or treatment of neurodegenerative disorders.

The present invention relates to methods of treating neurodegenerative disorders associated with Alzheimer's disease (AD), Parkinson's disease (PD) and synucleinopathies, such as dementia with Lewy bodies, Down Syndrome (DS) and associated cognitive disorders, multiple system atrophy, and rare neuroaxonal dystrophies, such as Niemann-Pick type C disease (NPC) and Gaucher's disease comprising administering an inhibitor to disrupt the interaction between Aβ or αS and neuronal lipids. The invention further relates to assays for identifying agents that reduce interaction between Aβ or αS and neuronal lipids. Lastly, the invention relates to methods and compositions for intranasal administration of fatty acids or lipids containing fatty acid acyl chains of dietary lipids for promoting central nervous system health and/or prevention or treatment of neurodegenerative disorders.

Provided herein are dry powder formulations comprising at least one active pharmaceutical ingredient suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including respiratory conditions, hemodynamic collapse, seizures, migraines, and other conditions.

Provided herein are dry powder formulations comprising at least one active pharmaceutical ingredient suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including respiratory conditions, hemodynamic collapse, seizures, migraines, and other conditions.