The present invention relates to an inhalation device (1), to the use thereof, and to a kit comprising the inhalation device. The inhalation device (1) has an air inlet (14), an air outlet (15) designed as a mouthpiece or nosepiece, and a recess (17) which is designed to receive a container (2) with an inhalable substance. An air duct (L) extends from the air inlet (14) through the recess (17) to the air outlet (15). Moreover, the inhalation device (1) has at least one hollow mandrel (16, 16′) which protrudes into the recess (17) and from which at least one air delivery line (14′, 14″) extends to the air inlet (14) or at least one air outlet line (15′) extends to the air outlet (15). The inhalation device (1) is characterized in that the inhalation device (1) has two limbs (11, 12), each with a work end (11′, 12′) and with an actuation end (11″, 12″), wherein the limbs (11, 12) are connected by means of a joint (13) which lies between the work ends (11′, 12′) and the actuation ends (11″, 12″). Furthermore, the recess (17) is defined between the mutually facing sides of both limbs (11, 12) at the work ends (11′, 12′), wherein the at least one hollow mandrel (16, 16′) is arranged inside the recess (17) on one of the mutually facing sides of both limbs (11, 12). The air inlet (14) and the air outlet (15) are arranged at the work end (11′, 12′) on a side, directed away from the recess (17), of at least one of the limbs (11, 12).

The present invention relates to an inhalation device (1), to the use thereof, and to a kit comprising the inhalation device. The inhalation device (1) has an air inlet (14), an air outlet (15) designed as a mouthpiece or nosepiece, and a recess (17) which is designed to receive a container (2) with an inhalable substance. An air duct (L) extends from the air inlet (14) through the recess (17) to the air outlet (15). Moreover, the inhalation device (1) has at least one hollow mandrel (16, 16′) which protrudes into the recess (17) and from which at least one air delivery line (14′, 14″) extends to the air inlet (14) or at least one air outlet line (15′) extends to the air outlet (15). The inhalation device (1) is characterized in that the inhalation device (1) has two limbs (11, 12), each with a work end (11′, 12′) and with an actuation end (11″, 12″), wherein the limbs (11, 12) are connected by means of a joint (13) which lies between the work ends (11′, 12′) and the actuation ends (11″, 12″). Furthermore, the recess (17) is defined between the mutually facing sides of both limbs (11, 12) at the work ends (11′, 12′), wherein the at least one hollow mandrel (16, 16′) is arranged inside the recess (17) on one of the mutually facing sides of both limbs (11, 12). The air inlet (14) and the air outlet (15) are arranged at the work end (11′, 12′) on a side, directed away from the recess (17), of at least one of the limbs (11, 12).

A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.

A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.

A method is provided that includes intranasally dispensing nasal wash fluid (26) into a nasal cavity (22) of a subject such that the nasal wash fluid (26) washes biological material into an oropharynx (30) of the subject from (a) the nasal cavity (22), (b) a nasopharynx (32) of the subject, or (c) the nasal cavity (22) and the nasopharynx (32). Thereafter, a specimen sample (24) is collected that passed out of an anterior opening (34) of an oral cavity (36) of the subject and contains at least a portion of the biological material washed into the oropharynx (30) by the nasal wash fluid (26). Other embodiments are also described.

A veterinary subject intranasal administration device includes a first support member portion including a septum interface portion sized for insertion into a nasal passage of the veterinary subject; an actuation mechanism connected to the first support member portion; and a fluid conduit having a distal end opposite a supported end, the distal end sized for insertion into the nasal passage of the veterinary subject, the fluid conduit being flexible and configured to receive fluid from a fluid source and discharge the fluid through the distal end into the nasal passage, the distal end of the fluid conduit being unsupported and movable relative to the septum interface portion.

A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.

A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.

Nasal cannula apparatus, includes in an inlet tubular fitting sized and configured to directly endwise connect to a source of oxygen, or oxygen and air. The fitting defines an inlet flow passage area A, having a 15 mm external diameter. A pair of tubular prongs is operatively connected with the inlet fitting, and receivable in an infant's nostrils to deliver oxygen, or oxygen and air flow to the infant, the prongs each having flow passing area A.sub.3, and A.sub.1>>A.sub.3.

Disclosed are methods involving the therapeutic use of human PRG4 (PRG4) protein, to ameliorate the symptoms associated with allergies and/or respiratory infections.