Provided herein are drug products adapted for nasal delivery comprising a device and a pharmaceutical composition comprising an opioid receptor antagonist or unit doses thereof, pharmaceutical compositions comprising an opioid receptor antagonist, and methods of use and preparation thereof.

An assistance device for a product dispensing device is provided, in which product dispensing is implemented by displacement or deformation of a moving part of the dispensing device between a rest position and an activation position. The assistance device includes an engaging unit, a locking unit configured to prevent the dispensing of the product, an actuator configured to switch the locking unit from a locked position to an unlocked position, a return unit configured to switch the locking unit from the unlocked position to the locked position, out of the activation position of the product dispensing, a blocking unit for blocking the locking unit in the unlocked position, a first disengagement member for disengaging the blocking unit configured to be triggered upon the activation of the dispensing device, and a second disengagement member for disengaging the blocking unit configured to be triggered independently of the activation of the dispensing device.

An assistance device for a product dispensing device is provided, in which product dispensing is implemented by displacement or deformation of a moving part of the dispensing device between a rest position and an activation position. The assistance device includes an engaging unit, a locking unit configured to prevent the dispensing of the product, an actuator configured to switch the locking unit from a locked position to an unlocked position, a return unit configured to switch the locking unit from the unlocked position to the locked position, out of the activation position of the product dispensing, a blocking unit for blocking the locking unit in the unlocked position, a first disengagement member for disengaging the blocking unit configured to be triggered upon the activation of the dispensing device, and a second disengagement member for disengaging the blocking unit configured to be triggered independently of the activation of the dispensing device.

In general, systems for administering a dmg are provided. In an exemplary embodiment, a dmg administration system includes a dmg administration device configured to communicate with a computer system and at least one sensor configured to obtain sensor data and communicate the sensor data to the drug administration device. The dmg administration device is configured to utilize a first drug dosing scheme when a drug is delivered to a patient, determine a second drug dosing scheme for delivering a drug to the patient dependent on dosing data from the computer system and sensor data collected by the sensor during and/or after the delivery of the first drug according to the first drug dosing scheme, and utilize the second drug dosing scheme when the drug is delivered to the patient.

In general, systems for administering a dmg are provided. In an exemplary embodiment, a dmg administration system includes a dmg administration device configured to communicate with a computer system and at least one sensor configured to obtain sensor data and communicate the sensor data to the drug administration device. The dmg administration device is configured to utilize a first drug dosing scheme when a drug is delivered to a patient, determine a second drug dosing scheme for delivering a drug to the patient dependent on dosing data from the computer system and sensor data collected by the sensor during and/or after the delivery of the first drug according to the first drug dosing scheme, and utilize the second drug dosing scheme when the drug is delivered to the patient.

A treadmill may include two separate left and right belts rotating around two sets of rollers, four legs having an adjustable height via air suspension to customize an inclination of the treadmill, a thermoelectric assembly, a fragrance assembly having a rotating fragrance cartridge to emit various smells toward a user of the treadmill, a display on which exercise programs are played, and an attachment module having a dispensing tray on which treats are dispensed. A handle of the treadmill may have a sensor to sense a height and front-rear position, and a belt divider provided between the left and right belts may have position or proximity sensors to sense a left-right position. An inclination of the treadmill may be automatically adjusted according to positions detected by the sensors, and the fragrance assembly, attachment module, and inclination may be automatically operated in accordance with an exercise program played on the display.

Systems and methods for opening the eustachian tubes of a subject are provided. Aspects of the systems include: a swallow inducer; a nasal passage seal; a pressure source configured to apply positive pressure to a sealed nasal passage; a sensor configured to detect a parameter indicative of a swallow resultant palate closure; and a controller operably coupled to the pressure source and the sensor, wherein the controller is configured to cause the pressure source to apply positive pressure to a sealed nasal passage upon detection by the sensor of the parameter indicative of a swallow resultant palate closure. Also provide are methods of using the systems to open eustachian tubes. The systems and methods find use in a variety of different applications, e.g., the treatment of a subject for Otitis Media with Effusion (OME).

Systems and methods for opening the eustachian tubes of a subject are provided. Aspects of the systems include: a swallow inducer; a nasal passage seal; a pressure source configured to apply positive pressure to a sealed nasal passage; a sensor configured to detect a parameter indicative of a swallow resultant palate closure; and a controller operably coupled to the pressure source and the sensor, wherein the controller is configured to cause the pressure source to apply positive pressure to a sealed nasal passage upon detection by the sensor of the parameter indicative of a swallow resultant palate closure. Also provide are methods of using the systems to open eustachian tubes. The systems and methods find use in a variety of different applications, e.g., the treatment of a subject for Otitis Media with Effusion (OME).

A syringe-shaped spraying device includes: a syringe-shaped spraying device main body including a barrel that stores a liquid medicine, a plunger having a front end inserted in the barrel with a gasket being attached to the front end, and a nozzle that is provided with a spraying hole for spraying the liquid medicine and that is connected to a front end of the barrel; a vial adapter having a transfer needle to pierce a vial that stores a liquid medicine so as to suction the liquid medicine; and a connection adapter that is attached to the syringe-shaped spraying device main body and that connects the vial adapter to the syringe-shaped spraying device main body.

A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.