A novel oxygen pulse therapy methods of treating subjects suffering from COVID19 and other respiratory and others diseases are provided. Aspects of the methods including administering to the subjects an effective amount of oxygen as pulses through the respiratory tract are included. Also provided are methods of assessing severity of the disease, mild, moderate, severe, or critical, and oxygen doses and frequencies. The method can be applied to viral, bacterial, fungal or parasitic respiratory and others diseases infections such as corona virus (SARS-CoV-2), influenza virus such as influenza A or rotavirus, bacterial pneumonia and meningitis such as Streptococcus pneumonia or parasitic and other diseases such AIDS, Ebola, tuberculosis and malaria.

A ventilation adjustment method and a high-frequency ventilation system, which ensure stable and accurate oxygen concentration control within an oxygen concentration setting range, are disclosed. The ventilation adjustment method includes: determining a first gas flow rate control value and a second gas flow rate control value according to a target output flow rate and an oxygen concentration setting value; determining whether the first gas flow rate control value falls into a first dead zone range and whether the second gas flow rate control value falls into a second dead zone range; if the first gas flow rate control value falls into the first dead zone range, maintaining a first gas flow rate controller turned on in an expiratory phase; and if the second gas flow rate control value falls into the second dead zone range, maintaining a second gas flow rate controller turned on in the expiratory phase.

A method of method of high flow oxygen therapy (HFOT) and carbon dioxide (CO.sub.2) monitoring includes delivering high flow oxygen therapy (HFOT) via a central lumen of a nasal cannula, the nasal cannula comprising a proximal end, a distal end positioned within a pharynx region of a patient's airway, and the central lumen and a sampling lumen formed within a wall of the nasal cannula. The method also includes receiving sampled exhaled breath of the patient via the sampling lumen at a CO.sub.2 monitor, wherein the sampling lumen is configured to sample the exhaled breath at the pharynx region through the CO2-permeable membrane and direct the sampled exhaled breath to a CO.sub.2 monitor fluidly coupled to the sampling lumen and determining a level of CO.sub.2 in the exhaled breath using the CO.sub.2 monitor.

In accordance with the present invention, there is provided an adaptor or attachment which is suitable for integration into the patient circuit of a ventilation system, such as a non-invasive open ventilation system, is configured for attachment to any standard ventilation mask, and is outfitted with a jet pump which creates pressure and flow by facilitating the entrainment of ambient air. The adaptor comprises a base element and a nozzle element which are operatively coupled to each other. The base element further defines a throat and at least one entrainment port facilitating a path of fluid communication between the throat and ambient air. The nozzle element includes a jet nozzle, and a connector which is adapted to facilitate the fluid coupling of the nozzle element to a bi-lumen tube of the patient circuit. The connector includes both a delivery port and a sensing port. The jet nozzle and the delivery port collectively define a delivery line or lumen which fluidly communicates with the throat of the base element, and is placeable into fluid communication with the delivery lumen of the bi-lumen tube.

A method of estimating a parameter indicative of respiratory flow of a patient being administered flow therapy, comprising: optionally administering a gas at a flow rate to the patient using a flow therapy apparatus with a patient interface, determining a terminal pressure in, at or proximate the outlet of the patient interface or in, at or proximate the nares of the patient, determining nasal RTF, determining a nasal flow parameter being or indicative of nasal flow based on the pressure and a nasal RTF, and optionally outputting the nasal flow parameter or parameter derived therefrom.

An oxygen concentration system may comprise a pressure sensor, a movement sensor, and a controller configured to use one or more pressure signals obtained from the pressure sensor and a movement signal obtained from the movement sensor to determine when to release a bolus of oxygen enriched air. In some implementations, the controller may adjust a trigger threshold based on an initial pressure signal obtained from the pressure sensor and the movement signal obtained from the movement sensor. In some implementations, the controller may adjust a pressure signal obtained from the pressure sensor based on the movement signal obtained from the movement sensor. In some implementations, the controller may detect a potential onset of inhalation from a pressure signal obtained from the pressure sensor and determine whether to verify the potential onset of inhalation based on the movement signal obtained from the movement sensor.

One aspect of the present disclosure relates to a system for providing non-invasive, high frequency ventilation to a neonate or an infant in need thereof. The system can include a tubing array, a vibration device, and a bifurcated cannula. The tubing array can be adapted to receive a flow of pressurized gas therethrough. The vibration device can be fluidly coupled to the tubing array and configured to generate and apply a jet of air to the flow of pressurized gas. The bifurcated cannula can be fluidly coupled to the tubing array and have independently movable first and second prongs that are sized and dimensioned for insertion into first and second nostrils, respectively, of the neonate or the infant.

The invention relates to a ventilator comprising a gas source, at least one gas path and a patient conduit and at least two valves, each of the valves having at least indirectly a port for the surrounding air and each of the valves being at least temporarily connected to the gas source and/or the patient conduit so as to conduct gas.

The present system (10) comprises a subject interface (22), a segmenter (12), a loosener (14), sensors (18), and computer processors (28). The segmenter is configured to selectively control gas flow through the subject interface to provide high amplitude pressure oscillations (44) during exhalation such that the high amplitude pressure oscillations aid cough productivity in the subject. The loosener controls gas flow through the subject interface to provide low amplitude pressure oscillations (43, 63) during inhalation (48, 68) and exhalation (49) such that the low amplitude pressure oscillations loosen respiratory secretions. The computer processors detect trigger events based on the output signals such that the one or more trigger events include a loosening trigger event and a segmenting trigger event (66); and responsive to detecting the loosening trigger event, control the loosener to provide the low amplitude pressure oscillations, and, responsive to detecting the segmenting trigger event, control the segmenter to provide the high amplitude pressure oscillations.

Provided are concepts for controlling a high flow nasal therapy (HFNT) device used by a subject. In particular, physiological and movement parameter values of the subject are leveraged in order to generate a control signal for the HFNT device. These parameters may indicate an activity level of the subject, as well as the condition of the subject, providing information useful for setting appropriate operating conditions of the HFNT device. Thus, a means for automatically controlling a HFNT device based on needs of the subject may be provided, improving subject comfort during therapy, and ease of use of the HFT device.