The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary, substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.

A die plate is provided for an underwater pelletizer. The die plate includes a die plate body and a solid face plate. The downstream face of the die plate body has a plurality of insulation holes drilled therein that reduce the surface area contact between the die plate body and the solid face plate that is secured to the downstream face of the die plate body to form the cutting surface. In addition, a circular groove is preferably milled into the downstream face of the die plate body. The groove is concentric with the outer perimeter of the die plate body and creates an outer ring and a center boss. The outer downstream surface of the boss is flush with the outer downstream surface of the outer ring so that the boss and ring together form the downstream face of the die plate body for supporting the solid face plate. The insulation holes and groove are filled with a non-reactive atmosphere such as nitrogen, inert gas(es), a vacuum or a partial vacuum.

The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

Methods of coating a base tube are disclosed. Various methods include passing a hollow base tube into a coating die while maintaining a chamber pressure outside the hollow base tube that is lower than a pressure within an inner lumen of the hollow base tube. Such methods can include extruding coating material onto the hollow base tube to form a coated hollow tube by delivering coating material into the coating die. Vacuum may be formed within the coating die proximate a point of impingement where the coating material is applied to the hollow base tube.

A method of producing a piezoelectric nanofiber web, includes: dissolving polylactic acid in a solvent, thus preparing a spinning solution; and electrospinning the spinning solution, yielding a nanofiber web, wherein at least 80% of a monomer for the polylactic acid comprises an L-isomer or a D-isomer, and wherein the solvent is a mixture comprising chloroform and one of N,N-dimethylacetamide(DMAc), N,N-dimethylformamide(DMF) and dimethylsulfoxide(DMSO).

A cable core includes: an internal conductor; a foamed dielectric that includes a fluororesin and is formed on the internal conductor by extrusion molding; and a skin layer that covers the foamed dielectric, and is configured such that a foaming rate of the foamed dielectric is 80% or more, an average foamed cell diameter of the foamed dielectric is 10 m or less, and a standard deviation of a foamed cell diameter of the foamed dielectric is 2.5 or less.

The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.

The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

In a cost-effective and qualitatively better method for producing spacers for a winding unit of an electrical high-voltage device, at least two starting components are mixed together in a mixing chamber under vacuum to form a component mixture. The component mixture is transferred to an extrusion housing, likewise under vacuum, of an extruder in which a transport device is arranged and which is equipped with a mouthpiece delimiting an outlet opening. The extrudate exiting from the mouthpiece is cured by the addition of heat in a vacuum in order to obtain the spacers.