A single treatment catheter is provided for delivery of brachytherapy radiation in combination with intratumoral injection into tumor tissue with a single skin and tumor insertion site. The catheter also enables precise delivery of anti-cancer agents, such as immunotherapy or other medical substances, to specific locations within the tumor with radiographic confirmation of the injection delivery area and location.

A torque limiting mechanism between a medical device and an implantation accessory is disclosed. In a particular embodiment, a delivery system for a leadless active implantable medical device includes a delivery catheter and a torque shaft disposed within the delivery catheter. The delivery system also includes a docking cap having a distal end for engaging an attachment mechanism of the leadless active implantable medical device. The delivery system also includes a torque limiting component coupled to a distal end of the torque shaft and a proximal end of the docking cap.

The invention comprises an indwelling medical device which is capable of delivering a therapeutic agent evenly along the length of the indwelling portion, including the outer wall, of the device.

A catheter control system can include a guide catheter that has a distal end configured to be positioned within an artery. The system can include a guide extension catheter positioned within the guide catheter and configured to extend from the distal end of the guide catheter and a catheter control center at a proximal end of the guide catheter. The catheter control center can include a guide extension advancement mechanism. The guide extension advancement mechanism is in communication with the guide extension catheter and is configured to move the guide extension catheter within the guide catheter and extend the guide extension catheter from the distal end of the guide catheter. The catheter control center can include a valve at a proximal end of the catheter control center configured to allow passage of wires and/or devices between the valve and guide catheter.A catheter control system can include a guide catheter that has a distal end configured to be positioned within an artery. The system can include a guide extension catheter positioned within the guide catheter and configured to extend from the distal end of the guide catheter and a catheter control center at a proximal end of the guide catheter. The catheter control center can include a guide extension advancement mechanism. The guide extension advancement mechanism is in communication with the guide extension catheter and is configured to move the guide extension catheter within the guide catheter and extend the guide extension catheter from the distal end of the guide catheter. The catheter control center can include a valve at a proximal end of the catheter control center configured to allow passage of wires and/or devices between the valve and guide catheter.

A transfer device includes an introducer coupleable to a peripheral intravenous catheter, with the introducer having a proximal end portion and a distal end portion, a catheter having a proximal end portion and a distal end portion and defining a lumen, a secondary catheter having a proximal end portion and a distal end portion and defining a lumen, and an actuator receiving the proximal end portion of the catheter and the distal end portion of the secondary catheter. The actuator is moveable within introducer from a first position where the distal end portion of the catheter is positioned within the introducer to a second position where the distal end portion of the catheter is positioned outside of the introducer.

A catheter is provided which includes an outer catheter and an extendable inner catheter. A sealing feature is positioned between the inner catheter and the outer catheter to seal the annular gap between the two while allowing axial translation. The seal may be a compliant protrusion surrounding the inner catheter and may have a chevron-shape for facilitating axial translation. The seal may be a one-way valve configured to allow antegrade flushing but prevent retrograde flow. The seal may be squeegee-like flange on the distal tip of the outer catheter. The seal may be an expandable bulge, which may be mechanically expandable or inflatable or which may be a photosensitive or electrosensitive hydrogel. The seal may include a spring that is radially compressed upon translation or rotation of the inner catheter to transiently break the seal. Also provided is a seal for sealing between the catheter and the vasculature.

In some examples, a device includes a catheter insert elongated body defining a body lumen, the catheter insert elongated body being configured to be at least partially inserted to a catheter lumen defined by a catheter without covering a first fluid opening of the catheter and to form a fluidically tight coupling with the catheter, and one or more sensors positioned on the elongated body. At least one of the one or more sensors are configured to sense a substance of interest. The catheter insert elongated body includes a material that is a substantially non-permeable to the substance of interest.

A robotic catheter can include bi-stable concentric tubes and a torsional spring mechanism that can provide torque at the proximal extremity of one or more tubes. The robotic catheter can compensate for the energy that may be released by the tubes snapping from on stable-equilibrium position to another by using the energy stored in the torsional spring mechanism. The energy released by the tubes upon snapping from one stable-equilibrium position to the other can be compensated by the energy stored in the torsional spring at the base, thereby resulting in the first, energy-free, zero stiffness catheter system that (1) synchronizes with the motion of the heart and (2) naturally results in optimal, pseudo-constant contact force with the tissue.

The disclosure provides for an adjustable catheter system with isovolumetric suction and restoration of fluid for the removal of a thrombus and a method of use thereof. The catheter system includes an inner catheter and an outer sheath surrounding at least a portion of the inner catheter. The inner catheter may include at least three lumina extending from the proximal end to the distal end of the inner catheter, at least one infusion fenestration along the infusion segment, and a distal encapsulation balloon at the distal end. The outer sheath may include at least three lumina extending from the proximal end to the distal end of the outer sheath and a proximal encapsulation balloon at the distal end. The catheter system may further include an agitator for mechanical morcellation of the thrombus.

A system can comprise a catheter and a device having an elongate member and an expandable member. The expandable member can be coupled to the elongate member. The elongate member can extend through the catheter. The expandable member can be positioned with a proximal member end proximal to a distal catheter end, a distal member end positioned distal to the distal catheter end, and at least a portion of the expandable member between the distal catheter end and the distal member end in an expanded state in which a maximum transverse dimension of the expandable member is larger than a maximum transverse dimension of the distal member end. The catheter can be advanced in a patient's body with the expandable structure, in the expanded state, at the distal end of the catheter.