Microcatheter for delivering a substance (e.g., infusion agent including embolization material and/or contrast enhancing material) in a small blood vessel towards a target bodily part. Includes a single lumen surrounded by tubular wall having outer diameter and opened at both ends; tubular wall proximal portion is connectable to a pressure source and reservoir containing infusion agent, and tubular wall distal portion ends with a tip; the tubular wall distal portion includes an infusion agent flow disruption section configured to disrupt passage therethrough of incoming retrograded flow of infusion agent, during continuous delivery of infusion suspension from the reservoir to the tip. Disclosed are methods using the microcatheter for performing local embolization in a small blood vessel feeding a (for example, cancerous) target bodily part, and for delivering infusion agent in a small blood vessel towards such target bodily part. Also disclosed are devices and methods for filtering non-target infusion agent.

An occlusive device, occlusive device delivery system, method of using, and method of delivering an occlusive device, and method of making an occlusive device to treat various intravascular conditions is described.

The present disclosure provides constructs comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a connexin 26 protein. Exemplary constructs include AAV constructs. Also provided are methods of using disclosed constructs for the treatment of hearing loss and/or deafness.

The invention provides a filter assembly including a string or wire such that a lasso type cincture is effected, said filter being openable and closeable while in deployed within a bodily vessel. A string lengthen or shorting adjustment mechanism, such as a ratchet or reel allows more length of string into the device or alternatively to shorten the length of available string in the system. The described invention, when used to ameliorate venous clots and most arterio-venous dialysis grafts, a filter-tipped aspirator is used downstream from the clot to capture and remove dislocated emboli. A method of using same is disclosed.

A medical device system may include an elongate shaft having a lumen extending to a distal end of the elongate shaft, wherein a proximal portion of the elongate shaft is configured to disengage from a distal portion of the elongate shaft; a medical device disposed proximate the distal end of the elongate shaft; a release wire disposed within the lumen of the elongate shaft, wherein the release wire releasably attaches the medical device to the distal end of the elongate shaft; and an introducer sheath slidably disposed over the elongate shaft, wherein the introducer sheath is configured to disengage the proximal portion of the elongate shaft from the distal portion of the elongate shaft.

A system for providing a continuous passage through a delivery catheter comprising a handle that defines an internal chamber. A first tube having a proximal end and a distal end and a first bore, the first tube being fixedly mounted within the handle, wherein the first bore at the distal end of the first tube is shaped to define a first inverse conical surface. A second tube having a proximal end and a distal end and a second bore, the second tube being slidably mounted within the handle, wherein the second bore is in axial alignment with the first bore. A third tube having a proximal end and a distal end and a third bore.

An example system for deploying an intrasaccular implant to occlude an aneurysm can include the intrasaccular implant with a securing ring thereon, a pusher, a securing wire with an extended securing feature thereon, and a pull wire. The system can be sized to be delivered intravascularly within a microcatheter. During delivery and manipulation of the implant, the securing ring can be held between the pusher and the securing feature of the securing wire with the securing wire and pull wire extended through securing ring. To deploy the implant, the pull wire can be retracted proximally to thereby allow the securing feature to pass through the securing ring and release the implant. The pusher can include a hypotube and/or an extended pushing feature on the securing wire.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

Systems and methods for positioning a wire for advancement through a vessel wall, and advancing it through one or more vessel walls, generally include a delivery catheter and an alignment catheter or a receiving catheter, and a guidewire. In some variations, the systems and methods may be used to bypass an occlusion or other barrier that may prevent advancement of a wire or tools through an endoluminal space. In these variations, the systems and methods include a delivery catheter, a bypass catheter, a receiving catheter, and a guidewire. The delivery and receiving catheters each generally include a side aperture, a deflection surface, and an alignment element, and the bypass catheter generally includes two side apertures, two deflectors, and two alignment elements. In some variations, the systems and methods may assist in treatment of a patient suffering from critical limb ischemia.

A catheterization system for treatment of patients can include a peripherally inserted central catheter comprising a catheter tube joined to an extension leg with a junction and a securement device that fits around a portion of the junction to inhibit movement. The catheter tube can include a taper proximate the junction, the taper transitioning the catheter tube from a larger outer diameter and a larger wall thickness to a smaller outer diameter and a smaller wall thickness. The taper and thicker wall thickness near the junction can help prevent damage to the catheter tube near the junction when bent (e.g., to secure a proximal region of the catheter to a patient's arm). The securement device can configured to fit around an outer diameter of the junction to inhibit movement of the junction when the junction is held in the securement device.