A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

In some embodiments, a catheter system may include a catheter adapter having a distal end, a proximal end, and a lumen extending there between. In some embodiments, the catheter system may also include a catheter extending distally from the distal end of the catheter adapter, an extension tube, and a connector coupled to a proximal end of the extension tube. In some embodiments, a distal end of the extension tube may be coupled to the proximal end of the catheter adapter. In some embodiments, the connector, the extension tube, the lumen, and the catheter may form a straight pathway for delivery of an instrument to the catheter system. In some embodiments, an extension set for a catheter assembly may include the extension tube, the connector coupled to the proximal end of the extension tube, and another connector coupled to the distal end of the extension tube.

Embodiments relate to a crosslinked citrate-based elastomer catheter that is biodegradable and kink resistant. Embodiments of the crosslinked citrate-based elastomer material swells when surrounded by fluid (body fluid) so as to anchor the catheter to tissue but not anchor it so much that movement or removal will cause tissue damage. The catheter can be used as a component to a peripheral nerve block device, for example. Embodiments of the catheter can include embedding biodegradable sensors, moieties, shape memory material, etc. to monitor and modulate functions of the catheter and/or peripheral nerve block.

Disclosed herein is a drug-coated balloon catheter including: a hub; a soft tip; a tube which connects the hub and the soft tip and is formed of a material having higher rigidity than the soft tip; and a balloon which is mounted on the tube and coated with a drug on the surface, wherein the tube includes: a guide lumen which allows a guide wire to be movable, the guide wire being inserted into a blood vessel via the hub; and an injection lumen into which a contrast medium is injected, the contrast medium being injected into the balloon through the hub or discharged therefrom, wherein the injection lumen includes: a flow center which is a portion corresponding to a width of the guide lumen; and a pair of bend supports which is extended beyond both end portions of the guide lumen on both sides of the flow center and deformed in response to bending of the tube, and the injection lumen has a cross-sectional area more than a half of a cross-sectional area of the guide lumen.

This invention is directed to a medical device having a longitudinal axis, and including a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section, wherein the catheter control member can be configured to move relative to the shaft to move the steering section relative to the longitudinal axis. The medical device can also include a securing member configured to move relative to at least one of the handle and the catheter to releasably couple the handle control member to the catheter control member.

A retrieval probe for insertion of a bridle into a nasal passageway of a patient is provided. The retrieval probe includes a proximal end and a distal end, a catheter between the proximal end and the distal end, an inner core within a lumen of the catheter, and a magnetic tip disposed at the proximal end. The catheter includes a hollow section disposed between the magnetic portion and a distal end of the stiff inner core. The hollow section may be flexible and can be configured to bend at an angle of about 180 degrees. The system for securing a nasal tube can include a bridle having a magnetic connection portion; and a retrieval probe as described above. The magnetic connection portion of the bridle and the magnetic tip of the retrieval probe can be configured to magnetically couple during a procedure for inserting the bridle in a nasal passageway of a patient.

The invention provides an intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and a lubricious additive, wherein the lubricious additive comprises an amphiphilic molecule having a hydrophilic-lipophilic balance below 8.

To provide a guide wire shaping mold that reduces damage to a blood vessel by folding back a tip end of the guide wire and do not require heating treatment, and a guide wire shaping method using the guide wire shaping mold. A guide wire shaping mold configured to shaping by reducing an annular diameter of the guide wire in which a tip end is annularly arranged, the guide wire shaping mold includes a wire shaping portion configured such that an annular portion of the guide wire is arranged, and a wire drawing path formed in a passage way shape, communicating with the wire shaping portion, and configured to retract the guide wire in a linear direction and in a base end direction.

A dilator includes: a hollow shaft having a tapered portion whose outer diameter of the distal end is smaller than the outer diameter of the proximal end; a distal tip, whose proximal end is located at the distal end of the tapered portion, and which is provided to extend toward the distal end direction; and a spirally-arranged protruding portion provided on at least the outer peripheral surface of the tapered portion. The spirally-arranged protruding portion is formed by winding a wire and has gaps between portions adjacent to each other along the longitudinal direction of the hollow shaft. The inner peripheral radius CIDmin of a portion, which is the minimum inner peripheral radius of the spirally-arranged protruding portion, is smaller than the outer peripheral radius TODmax of a portion, which is the maximum outer peripheral radius of the distal tip.

An intravascular treatment system including an introducer sheath having an intentional friction zone along a section thereof imposing an intentional friction force on the outer surface of a catheter shaft slidable therein. The friction zone representing a non-straight (e.g., curved or bent) section of the introducer sheath and/or a section of the introducer sheath whose inner wall has a reduced inner diameter (e.g., fused heat shrink material). During intravascular treatment, sufficient axial force may be applied to overcome the imposed intentional friction force and advance the intravascular treatment device in a distal direction to a desired target site in the artery. Once properly positioned, the imposed intentional friction force ensures that the intravascular treatment device is maintained in place.