A composition for fused filament fabrication may include polylactic acid resin and talc. The composition may range from 50% by weight to 99% by weight polylactic acid resin, and from 7% by weight to 40% by weight talc. The composition may be configured as filaments or pellets adapted to be used in a fused filament fabrication process. A method for generating a resin-based structure may include providing a resin source that may include polylactic acid resin and talc. The resin source may include from 50% by weight to 99% by weight polylactic acid resin, and from 7% by weight to 40% by weight talc. The method may also include heating the resin source to a temperature greater than the melting temperature for semi-crystalline resins or significantly greater than glass transition temperature for amorphous resins, and depositing the heated resin source in a layered manner to form the resin-based structure.

A one-piece medical connector has a unitary body. The unitary body includes a rigid portion that forms a housing. The unitary body also includes a resilient portion located at least partially within the housing. At least a movable portion of the resilient portion is configured to move relative to the rigid portion. Movement of the resilient portion selectively permits fluid flow through the connector. The rigid portion and the resilient portion form a one-piece unitary connector.

A one-piece medical connector has a unitary body. The unitary body includes a rigid portion that forms a housing. The unitary body also includes a resilient portion located at least partially within the housing. At least a movable portion of the resilient portion is configured to move relative to the rigid portion. Movement of the resilient portion selectively permits fluid flow through the connector. The rigid portion and the resilient portion form a one-piece unitary connector.

An in-situ additive-manufacturing system for growing an implant in-situ for a patient. The system has a multi-nozzle dispensing subsystem and a distal control arm. The multi-nozzle dispensing subsystem in one embodiment includes first and second dispensing nozzles. The first and second nozzles include first and second printing-material delivery channels, respectively. In another embodiment, the in-situ additive-manufacturing system includes a multi-material subsystem having a dispensing nozzle including first and second printing material delivery channels. Controlling computing and robotics componentry are provided. In various aspects, respective storage for first and second printing materials, and one or more pumping structures, are provided.

An additive manufacturing device is provided and includes a printing material source, a printing head and a temperature control system. The printing material source is configured to contain a supply of printing material. The printing head is receptive of the printing material from the printing material source and is configured to print an object with the printing material. The temperature control system is coupled to the printing head and is configured to adjust a temperature of the printing material during printing to cause state changes of the printing material resulting in the printing material being one of soluble and insoluble in a solvent.

An additive manufacturing device is provided and includes a printing material source, a printing head and a temperature control system. The printing material source is configured to contain a supply of printing material. The printing head is receptive of the printing material from the printing material source and is configured to print an object with the printing material. The temperature control system is coupled to the printing head and is configured to adjust a temperature of the printing material during printing to cause state changes of the printing material resulting in the printing material being one of soluble and insoluble in a solvent.

One aspect of the invention provides a method of generating three-dimensional biological structures. The method includes: (a) depositing a first layer of a suspension over a substrate, the suspension including a liquid and a plurality of cells; (b) allowing the plurality of cells to attach to the substrate and form a first layer of attached cells; (c) depositing a cell-attachment agent over the first layer of attached cells; and (d) depositing a second layer of the suspension over the cell-attachment agent.

One aspect of the invention provides a method of generating three-dimensional biological structures. The method includes: (a) depositing a first layer of a suspension over a substrate, the suspension including a liquid and a plurality of cells; (b) allowing the plurality of cells to attach to the substrate and form a first layer of attached cells; (c) depositing a cell-attachment agent over the first layer of attached cells; and (d) depositing a second layer of the suspension over the cell-attachment agent.

A composition of matter comprises at least 10 wt % epoxy functionalized two-dimensional shaped particles, carbon nanotubes in the range of 0.1 to 5 wt %, epoxy resin and a curing agent. A method of manufacturing a composition of matter includes mixing epoxy resin, carbon nanotubes and a solvent to produce a material, drying the material, and mixing the material with a curing agent to product the composition of matter. A method of printing a composition of matter includes producing the composition of matter by combining epoxy functionalized graphene, carbon nanotubes, epoxy base resin, and a curing agent, extrusion printing the composition of matter into a desired pattern, and curing the pattern.

A composition of matter comprises at least 10 wt % epoxy functionalized two-dimensional shaped particles, carbon nanotubes in the range of 0.1 to 5 wt %, epoxy resin and a curing agent. A method of manufacturing a composition of matter includes mixing epoxy resin, carbon nanotubes and a solvent to produce a material, drying the material, and mixing the material with a curing agent to product the composition of matter. A method of printing a composition of matter includes producing the composition of matter by combining epoxy functionalized graphene, carbon nanotubes, epoxy base resin, and a curing agent, extrusion printing the composition of matter into a desired pattern, and curing the pattern.