A medical device may include a distal connector, which may include a first lever arm and a second lever arm. A distal end of the first lever arm and a first end of the second lever arm may include a first protrusion and a second protrusion, respectively. The distal connector may include a blunt cannula disposed between the first lever arm and the second lever arm. The medical device may include a cover coupled to the distal connector and having an annular wall surrounding the blunt cannula. The first protrusion and the second protrusion may contact at least one catch disposed on an outer surface of the annular wall. A proximal end of the first lever arm and a proximal end of the second lever arm may be configured to be pinched together to remove the first protrusion and the second protrusion from the at least one catch.

A blood collection device may be configured to couple to a catheter assembly. The blood collection device may include a housing, which may include a distal end, a proximal end, and a slot. The blood collection device may include a tube disposed within the housing. The blood collection device may include an advancement element configured to move along the slot. In response to distal movement of the advancement element along the slot, the tube may be configured to advance distally beyond the distal end of the housing. The instrument advancement device may include a coil extending distal to the tube.

A catheter assembly may include an adapter having a distal end, a proximal end, a side port, and an adapter lumen. The catheter assembly may include a catheter hub, which may include a distal end, a proximal end, a catheter hub lumen, and another side port. The catheter assembly may include an extension tube. A distal end of the extension tube may be coupled to the other side port, and the distal end of the adapter may be coupled to a proximal end of the extension tube. A fluidic seal may be formed around a tube of an instrument advancement device when the tube is advanced into the adapter. As an example, a portion of the adapter lumen between the distal end of the adapter and the side port may include an annular protrusion configured to form the fluidic seal.

A vascular access device may include an advancement element and a housing. The housing may include a lumen extending therethrough, which may be used for blood collection. The vascular access device may include a pair of opposing pinch members configured to pinch the housing. The pair of opposing pinch members may be configured to move along the housing with the advancement element. The vascular access device may include a guidewire, which may include a wedge. In response to moving the advancement element distally along the housing, the pair of opposing pinch members may move the wedge distally and the guidewire may be advanced distally. The proximal end of the guidewire may include a looped portion, and in response to moving the advancement element distally along the housing, the pair of opposing pinch members may be aligned with an opening formed by the looped portion and advance the guidewire distally.

Devices for transferring fluid to or from a subject include an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen. The devices also include an elongate needle having opposing proximal and distal ends. The elongate needle is configured so that the distal end of the needle extends out of the distal end of the cannula a suitable adjustable distance. The devices also include a housing with a length adjustment mechanism that adjusts a length between the tip of the needle and the distal end of the tubular cannula.

An indwelling catheter includes: a catheter configured to be indwelled in a living body; a catheter hub that holds and fixes the catheter; and a valve mechanism provided in a lumen of the catheter hub. The valve mechanism includes: a first member including a slit through which an inner needle is insertable, and a first liquid passage hole through which liquid is passable, a second member arranged adjacent to the first member and including a needle insertion hole through which the inner needle is insertable, and a second liquid passage hole through which the liquid is passable, and an operation member configured to move the first member and the second member relative to each between an open state and a closed state.

Provided is an insertion mechanism with increased reliability and reduced components. The insertion mechanism uses a single engagement and release clip compressed within a housing of the insertion mechanism to engage a needle hub and catheter hub. A button is provided to move the catheter hub and needle hub in a distal direction until the engagement and release clip reaches a firing window in the mechanism housing. The engagement and release clip expands in the release window to release the needle hub from the catheter hub, permitting a return spring to move the insertion needle proximally while leaving the catheter inserted, and also retains the catheter hub in the deployed position.

Methods of delivering cells and other therapeutic agents to organs and extravascular sites using an endoluminal delivery device are provided that allow for retention of the cells or agents at the delivery site at significantly improved levels as compared to needle delivery. Optimal delivery rates using the endoluminal delivery device are also provided. The methods allow for delivery of a variety of therapeutic agents to organs including heart, kidney and pancreas.

An improved wedge is provided for a septum and wedge subassembly in a fluid path of a fluid delivery device such as for use in a catheter insertion mechanism of a patch pump. The wedge has a retaining edge to provide axial force to retain a septum therein to obviate need for additional insertion mechanism components to retain the septum in place as a needle passes therethrough to facilitate insertion of a catheter and then retracts. The retaining edge can be rolled or flanged to extend at least partially over a surface of the septum. The wedge is also configured to provide radial compression on the septum to achieve a sufficient needle and septum interface seal to withstand a filling pressure of the fluid delivery device.

An extravascular system is provided which includes a catheter adapter having a blood control septum configured to control flow of a fluid through the catheter adapter, the catheter adapter further having a catheter configured for intravenous insertion. The extravascular system further includes a septum activator slidably inserted within the catheter adapter and configured for advancement through the blood control septum to provide a fluid pathway through the blood control septum. Further still, the extravascular system includes an external safety mechanism comprising a needle hub and a needle shield interconnected via a tether, wherein the needle shield includes a safety clip that is configured to retain a sharpened end of the introducer needle within the needle shield. Some implementations further comprise an access port forming a portion of the catheter adapter and providing selective access to the lumen of the catheter adapter.