Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for an implant, then return to a non-expanded state after the passage of the device. The sheath includes a foldable inner member having a detached flap structure at its distal tip that facilitates expansion of the sheath lumen to increased diameters, and an elastomeric distal end that reduces push and retrieval forces therethrough. The sheath can include a hemostasis seal on its proximal end to prevent the leakage of blood out of the sheath and prevent ballooning of outer layer of the sheath.

An introducer sheath is disclosed capable of reducing a physical burden on a patient by shortening a time necessary for hemostasis at an introduction part after removing the introducer sheath percutaneously introduced into a body lumen. The introducer sheath includes a catheter main body, which is percutaneously introduced into a body lumen, a hub, which is connected to a proximal side of the catheter main body, and a tube member which includes a thrombus inducing material M. The tube member is disposed at a proximal side of an outer surface of the catheter main body.

A vasculature access device may include a needle, a dilator, an introducer sheath, a hub, and manipulators in a single, integrated device. The vasculature access device may also optionally include one or both of a guidewire and one or more features for facilitating restraint of the hub and the introducer sheath relative to a patient. By integrating the needle, dilator, introducer sheath, hub, and manipulators in a single device, exchanges of these components (e.g., removing one component from the vasculature and introducing a different component into the vasculature), which is done in access kits where at least some of these components are separate, are reduced.

A device for occlusion removal from a bodily lumen is described. The device includes a multi-lumen catheter, a manifold that attaches to the catheter, and an aspiration device that inserts through a lumen of the catheter. A method of removing an occlusion from a bodily lumen is also described, as is a kit containing the device.

An integrated vascular access device can include strain relief features to minimize the likelihood of the extension tubing becoming kinked during use. These strain relief features can be configured at both ends of the extension tubing to minimize the likelihood of kinking at the interfaces to the catheter adapter and luer adapter. To provide strain relief at the catheter adapter end of the extension tubing, an interface formed of a flexible material can be aligned with an extension of the catheter adapter into which the extension tubing inserts. The interface can be integrated into a stabilization platform or formed separately from a stabilization platform. To provide strain relief at the luer adapter end of the extension tubing, a flexible spacer can be coupled to a distal end of the adapter and have a distal portion that is positioned around the extension tube.

A drug delivery system is described. The system has a first fluid delivery reservoir and a second fluid delivery reservoir. The first reservoir is separately controllable from the second reservoir. The first reservoir and second reservoir are attached to a manifold having a first solution channel in fluid communication with the first reservoir and a second solution channel in fluid communication with the second reservoir. The manifold is connected to a catheter having a first lumen in fluid communication with the first solution channel and a second lumen in fluid communication with the second solution channel. The catheter has a first balloon in fluid communication with the first lumen and a second balloon in fluid communication with the second lumen. The first balloon is located within the second balloon. The first balloon is not in fluid communication with the second balloon and the second balloon is perforated. A method for using the system and a kit containing the system are also described.

A drug delivery system is described. The system has a first fluid delivery reservoir and a second fluid delivery reservoir. The first reservoir is separately controllable from the second reservoir. The first reservoir and second reservoir are attached to a manifold having a first solution channel in fluid communication with the first reservoir and a second solution channel in fluid communication with the second reservoir. The manifold is connected to a catheter having a first lumen in fluid communication with the first solution channel and a second lumen in fluid communication with the second solution channel. The catheter has a first balloon in fluid communication with the first lumen and a second balloon in fluid communication with the second lumen. The first balloon is located within the second balloon. The first balloon is not in fluid communication with the second balloon and the second balloon is perforated. A method for using the system and a kit containing the system are also described.

A catheter may include a hypotube defining an inner circumferential surface, an outer circumferential surface, and an end. The hypotube may include a metal or alloy. The catheter also may include an inner liner attached to the inner circumferential surface of the hypotube and extending beyond the end of the hypotube, and the inner liner may include a fluoropolymer. The catheter further may include a hub and a single bonding layer attached to the outer circumferential surface of the hypotube and bonded to the hub. The single bonding layer may include a polyamide, a polyether-co-polyamide, or polyurethane and is the only layer between the outer circumferential surface of the hypotube and the hub.

A catheter assembly comprising a catheter handle (101) with a collet (118) disposed at a distal end. The collet is coupled to a strain relief (107) comprising a nut (122) and a strain relief projection (135). The collet comprises at least one leaflet (124, 125) and at least one collet spur (672, 682), and the nut comprises at least one ratchet (251). The collet is configured to couple to the nut, and the at least one ratchet is configured to interact with the at least one collet spur to securely fasten the strain relief to the catheter handle. The at least one leaflet is configured to couple to a catheter shaft.

Devices, systems and methods are used to decouple proximal movement of a catheter supply lead or tubing from the tissue-embedded catheter. A catheter decoupling device comprises a catheter hub, sled and track, wherein the hub comprises a proximal end configured to receive a catheter fluid supply device, and a distal end configured to receive a catheter, the sled receives and retains the hub, the track receives and retains the hub; and, the hub has a limited range of back-and-forth motion relative to the track.