A method for designing and manufacturing a long release capsule for extended delivery of a drug to a patient in an ingestible capsule. The method includes determining a drug volume to be delivered and a drug delivery rate. A buoyancy element is selected based on the drug volume. A release port is selected based on the drug delivery rate and the properties of the drug. The design elements are used to produce a capsule design for an ingestible capsule. The design of the capsule is used to generate manufacturing instructions and produce the capsule.

A miniature device is provided for use in a system configured to deliver a therapeutic component to a treatment site in a patient. The miniature device comprises at least one steering portion comprising a magnetic material, and at least one carrier portion affixed to the steering portion and comprising the therapeutic component. The carrier portion is configured to at least partially dissipate under one or more predetermined conditions at the treatment site, thereby releasing the therapeutic component. Further provided is a system comprising one or more such miniature devices and a magnetic inducing apparatus configured to be operated to generate a varying magnetic field, thereby remotely controlling motion of the miniature device.

Provided are gastric residence systems comprising: a core; a plurality of arms connected to the core at a proximal end through a plurality of linker components, one linker component of the plurality of linker components corresponding to each arm of the plurality of arms, and the plurality of arms extending radially from the proximal end, and a filament circumferentially connecting each arm of the plurality of arms.

Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane.

The present disclosure relates generally to the field of medical devices and establishing fluid communication between body lumens. In particular, the present disclosure relates to devices and methods for establishing a controlled flow or access passage between body lumens.

The present invention relates to a dual-body drug administration device which administers drugs and removes mucus from the paranasal sinus through the nostrils in order to prevent or treat a paranasal sinus disease and, more specifically, to a device in which two injectors having adapters coupled thereto are integrally fixed by a fixing holder, the adapters of the fixed injectors are simultaneously brought into contact with both the nostrils, and then negative pressure is generated in the nasal cavity to pull out mucus from the paranasal sinus or administer a drug to the paranasal sinus.

This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

The present invention relates to a vaginal drug delivery device configured to safely and effectively deliver a therapeutic formulation in the vagina at or near a desired target area for a specified time period.

Provided are gastric residence dosage forms comprising flexible arms that can help prevent premature passage of the gastric residence system through the pylorus of a patient. In particular, described herein are gastric residence systems comprising one or more arms extending radially, the one or more arms comprising a first segment comprising a first polymer composition and a second segment comprising a second polymer composition, wherein the first segment has a stiffness of greater than a stiffness of the second segment, as measured using a 3-point bending test per ASTM D790. The second segments of the arms of the gastric residence systems help prevent premature passage of the gastric residence system through the pylorus of a patient.