Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region, and the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Liquid applicators wherein the applicators include a lever having a hinge, grip and foot integrally formed with a hollow body suitable for receiving a liquid-filled ampoule. The foot is positioned adjacent the ampoule and crushes the ampoule when the lever is depressed.

Methods to provide customized skin care by using specimen dispensing device to dispense specimens from removable dispensers for the purpose of treating skin of a user are presented. Methods to utilize the embedded memory and electrical interface of the dispensing device and dispensers to produce customizable skin care products that give better skin treatment results are also presented. The invention may also be applied to health care and personal care needs.

A needle cap assembly for use in combination with a needle pen comprising: (i) a needle cap having a needle cannula for injecting a fluid medication into an injection site, (ii) an internal cap configured to be disposed over an injection end of the needle cap, (iii) an external cap having a cavity configured to envelop the internal and needle caps, (iv) a sealing tab configured to seal a cavity of the external cap for enclosing or housing the needle cap assembly, and (v) a cleansing swab disposed in internally of the needle cap assembly. The cleansing swab is disposed internally of the needle cap and includes an absorptive material loaded with a cleansing fluid to clean an injection site prior to injection of fluid medication.

Pharmaceutical compositions having enhanced active component permeation properties are described.

A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

The present invention is directed to a spray applicator for spraying a tissue treatment medicant onto a tissue that has a container containing the medicant and is positioned at a proximal end of the spray applicator; a spray tip positioned at a distal end of the spray applicator; a cannula connecting the container with the spray tip; an actuatable dispensing mechanism at a proximal end of the applicator to express the medicant from the container through the cannula and through the spray tip toward the tissue; an optional pressurized gas source discharging a gas through the cannula in the vicinity of the spray tip or inside the spray tip; and a distance indicator that provides indicia of the distance between the spray tip and the tissue but does not prevent positioning the spray tip closer to the tissue than a defined distance for the distance indicator.

A liquid dispensing applicator that can include a sound-generating system for generating a sound during rotation of the container body to indicate to a user that the rotation is performed. The sound-generating system includes at least one knob and a plurality of ribs. The at least one knob cooperates with at least some of the ribs during rotation of the container body, in order to generate the sound. The liquid dispensing applicator can alternatively or also include a wing element insertable into a slot provided in an absorbent material. The wing element extends from an outer surface of the head component and comprises opposing surfaces and a at least one edge spike provided on an edge of the at least one wing element, and configured to prevent the absorbent material from being removed after insertion of the wing element into the slot.

A handheld light treatment device that aims to provide a wide variety of uses in personal care and household cleaning. The device contains a panel with light sources positioned behind a translucent or transparent head plate, to which is attachable an applicator disc and, optionally, applicator disc attachments with selected functionalities. The light panel shines light of different frequencies that may be useful for cleaning and sanitizing various surfaces. The applicator disc and applicator disc attachments have a substantially translucent or transparent base, allowing light from the light sources to shine through the head plate as well as applicator disc and applicator disc attachment, and the applicator disc to rotate while the light panel remains fixed. The applicator disc and applicator disc attachments may have bristles or other surface elements to facilitate cleaning or other uses, and the device may dispense an ingredient.