Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

A needle assembly includes a catheter hub, a catheter tube extending distally from the catheter hub, and a needle hub having a needle having a needle tip extending out the catheter tube. A protective cap is positioned with the catheter hub and covers the catheter tube and the needle tip. The protective cap has a casing having a casing body, a first opening at a proximal end of the casing body, a proximal cavity having the needle tip and the catheter tube located in the proximal cavity, a second opening at an end opposite the first opening and opening into a distal cavity, and a rim at the second opening. A lid is removably attached to the rim at the second opening to seal a solution inside the distal cavity. The solution is dispensable from the distal cavity following separation of the lid from the rim.

A formula delivery system can be used in conjunction with hair and scalp treatment appliances to supply a hair treatment formulation to the appliance. In one aspect, the formula delivery system delivers hair coloring formulation to the appliance. Formula delivery systems of the present disclosure generally include at least one fluid container configured to retain a volume of formulation for delivery of the formulation to a hair coloring appliance. In this regard, the formula delivery system may be configured to removably couple to an inlet member of the appliance that allows the appliance to draw the formulation from the fluid container for use within the appliance.

A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.

A medicine application device with ultrasonic massage enabling concentrated supply of medicine, including a medicine concentrated supply device, at least one ultrasonic massage mechanism, a medicine supply pipe and power cables. The ultrasonic massage mechanism has a shell, a base panel having massage projections, and an electrical ultrasonic vibration element; the medicine concentrated supply device has a housing, a control panel, a circuit board, and a medicine supply device. The medicine application device provides high frequency ultrasonic massage and applies medicinal therapy to patients.

A handheld portable electrostatic device for electrostatically applying a treatment solution to a treatment site of a patient, including a housing and a cartridge removably disposed in the housing. The cartridge includes a cartridge housing and a nozzle for applying the treatment solution. An electrostatic module is provided to electrostatically charge and ionize molecules of the treatment solution of the cartridge. The treatment solution is configured to flow toward the nozzle whereby at least one electrode electrically connected to the electrostatic module physically contacts the treatment solution as it flows therethrough and applies an electrical charge to the treatment solution.

A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers.

A method for calibrating detectors of a self-contained, tissue oximetry device includes emitting light from a light source into a tissue phantom, detecting in a plurality of detectors the light emitted from the light source, subsequent to reflection from the tissue phantom, and generating a set of detector responses by the plurality of detectors based on detecting the light emitted from the light source. The method further includes determining a set of differences between the set of detector responses and a reflectance curve for the tissue phantom, and generating a set of calibration functions based on the set of differences. Each calibration function in the set of calibration functions is associated with a unique, light source-detector pair. The method further includes storing the set of calibration function in a memory of the self-contained, tissue oximetry device.

A device for discharging a flowable substance, in particular for applying a medical substance, a pharmaceutical substance, a food supplement or a cosmetics, includes_an activation mechanism and a body which has a discharge opening at a first end and forms a containing space in which a frangible capsule is disposed. The capsule has two ends each having a first and a second tip and at least one of the two tips can be snapped off by actuating the activation mechanism so that the flowable substance is discharged.

A skin treatment device and a method to cleanse and balance pH value of skin. The skin treatment device includes a nozzle to be directed into contact with the skin of a subject. A vacuum pump may be operably coupled to the nozzle for generating a suction force of the nozzle to evacuate impurities from the skin. A liquid replenishing assembly may be operably coupled to the nozzle for atomizing liquid at a pre-defined pH value. The liquid from the liquid replenishing assembly may pass into the nozzle based on the pre-defined pH value. The first control valve may be connected to an outlet of the vacuum pump and an outlet of the liquid replenishing assembly for communication with the nozzle.