A self-supporting applicator comprises a first structural element which is self-supporting and has a shape determined according to a target structure, the applicator further comprises an active agent.

The present application relates to an elastomeric article, such as a glove, comprising: (i) an elastomeric film comprising one or more film layers, and including an external surface and an internal surface, (ii) an antimicrobial agent that is effective against both beneficial and harmful microorganisms on the external surface of the elastomeric film, and (iii) a skin-protective agent selected from a probiotic, a prebiotic, or a combination thereof on the internal surface of the elastomeric film; wherein the inner surface of the film is free of an antimicrobially-effective amount of an antimicrobial agent that is effective against both beneficial and harmful microorganisms. The elastomeric articles may further comprise a barrier film layer that provides separation between the antimicrobial agent and the skin-protective agent. Also described are methods for the manufacture of such articles.

Disclosed are composition and methods for treating skin whereby a cosmetic composition is applied to a target area of skin. The cosmetic composition comprises an effective amount of a skin active agent. A barrier patch is also provided and has a backing layer and a pressure sensitive adhesive. The barrier patch has an adhesive release force of about 50 gms to about 400 gms; a WVTR from about 1 g/m.sup.2/24 h to about 500 g/m.sup.2/24 h; and a flexibility from about 8 grams to about 40 grams.

Devices and methods can be used to apply an adhesion promoter, for example, ozone, over the surface of the biological tissues, before and/or concurrently with the application of the cosmetics to improve the durability and/or appearance of the cosmetics on the biological tissues. The devices can include a recirculation system and/or a filter system to reduce the likelihood of the chemical being released into the atmosphere and/or to increase oxidation of the chemical generated by the device after use of the device.

A hemostatic device is provided to stop bleeding at a puncture site on an artery of a patient, the device comprising a transparent flexible band to be wrapped at the site where the bleeding is to be stopped, a curved compression member having an inner peripheral side and possessing a first curved portion in its first half and a second curved portion in its second half, a first balloon provided on the inner peripheral side in the first half of the curved compression member and a second balloon provided on the inner peripheral side in the second half of the curved compression member. The bleeding from a first artery is stopped by compressing the first artery at the puncture site using inflation of the first balloon and blood flow in the first artery is increased by compression of a second artery using inflation of the second balloon.

A two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element. The disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user. The transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch. The reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch. The solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system.

Technologies are described for delivery of compounds to aid in weight management. A transdermal microdispenser based system may deliver weight management compounds through the time and dose specific administration of appetite suppression, metabolic enhancers, and satiation compounds. The transdermal delivery system may be controlled based on data associated with subject such as calorie intake, physical activity, satiation, and hunger. The system may be integrated with medical monitoring or fitness tracking systems. Delivery of the compounds may be distributed over the course of a day at selected or adjusted doses to be safe and effective for their specific modality. For example, appetite suppressants may be delivered during periods of the day when cravings occur, satiation compounds may be delivered to coincide with meals, and metabolic stimulators may be delivered at times to optimally increase metabolism based on caloric balance. Control factors may also be predictive to prevent the onset of hunger.

Dry eye treatment apparatus and methods are described herein which generally comprise a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomian glands contained within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an underlying region of skin in proximity to one or both eyes of a subject such that the one or more strips allow for the subject to blink naturally without restriction from the one or more patches. Moreover, the one or more strips may be configured to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or more meibomiam glands contained within the underlying region of skin.

A composition for healing or improving skin includes a fabric or material impregnated with an oxygen generating material. The fabric may include a first side in contact with the skin for providing oxygen to the skin and a second side between the oxygen generating material and the air surrounding the skin to form a barrier for retaining heat and inhibiting evaporation.

The sheet mask includes multiple battery parts arranged such that electric currents flow along mimic muscles or flows of lymph. This allows an active ingredient to penetrate into in-body tissues more effectively and also allows the mimic muscles and the lymphatic vessels to be electrically stimulated. Forming the battery parts by using materials with low environmental load allows easy disposal of the sheet mask in everyday life.