A method for forming an applicator comprises steps of: creating a digital geometric representation of the structure, the target structure having a flatness ratio; forming the applicator using the digital geometric representation of the target structure, the applicator having a target structure contacting surface; and disposing an active agent upon the target structure contacting surface of the applicator.

A bioelectrode sheet (100) is configured to be affixed to the skin of a subject, a drug (104b) being mixed in an adhesive layer (104) provided at a peripheral position of a conductive gel layer (103) so as to avoid the conductive gel layer (103). The drug (104b) admixed with the adhesive layer (104) can thereby be caused to penetrate the body while biological information is acquired by an electrode (102) via the conductive gel layer (103).

A closed-loop wearable device or platform integrates sensors, actuators, and microcontroller on board. The device is applied directly to the skin using stretchable epidermal electronics. It can sense a variety of signals from the human body, thus collecting medically relevant information, and can activate delivery of a therapeutic upon detection of an abnormal condition. The therapeutic can be delivered at a personalized dosage and/or with a unique combination of drugs or other agents based on the individual's metabolism as tracked by various sensor modules integrated with the medical device.

This invention relates to reusable, multi-layered articles having the ability to maintain a desired temperature and be used for cosmetic and/or medical applications. In particular, the invention is directed to cosmetic facial masks and kits used to treat the skin of a user by applying heat or cold along with an optional therapeutic composition, and maintain the desired temperature during the duration of treatment. The multi-layered article is designed to be reusable, washable and sterilizable.

A portable transdermal administration patch apparatus comprises a communication control device and a pharmaceutical device which is fixed to and arranged at a lower end of the communication control device and electrically connected to the communication control device. The communication control device is formed of a micro-battery, a wireless control device and a micro-controller which are electrically connected. The preparation of the patch apparatus is achieved by: the preparation of medicinal patches and non-medicinal patches, the mounting of electrodes, interfacing with a micro-controller, and the communication control system, and starting administration. The transdermal apparatus is wearable and can be remotely controlled, and is convenient for administration, in particular, for the situations of daily administration for elderly patients with chronic illness and when there are a larger number of admitted inpatients, where a nurse can pre-set the administration time and dose, thus saving time and efforts of medical staff.

A benefit agent delivery system whereby benefit agents can be delivered on demand and/or a variety of different benefit agents at different concentrations can be delivered from the same system. The benefit agent delivery system includes a microcell layer comprising a plurality of microcells, wherein the microcells are filled with a carrier and a benefit agent. The microcells include an opening, wherein the opening is spanned by a sealing layer comprising a polymer and metallic material. Application of an electric field across the microcell layer and the sealing layer results in the migration of the metallic material from the sealing layer and the creation of a porous sealing layer, allowing the benefit agent to be released from the benefit agent delivery system.

A benefit agent delivery system whereby benefit agents can be delivered on demand and/or a variety of different benefit agents at different concentrations can be delivered from the same system. The benefit agent delivery system includes a microcell layer comprising a plurality of microcells, wherein the microcells are filled with a carrier and a benefit agent. The microcells include an opening, wherein the opening is spanned by a sealing layer comprising a polymer and metallic material. Application of an electric field across the microcell layer and the sealing layer results in the migration of the metallic material from the sealing layer and the creation of a porous sealing layer, allowing the benefit agent to be released from the benefit agent delivery system.

A delivery device includes a collar device for wearing on an animal, a dosing probe disposed on the collar device for delivering a substance therefrom, an actuator configured to deliver the substance from the dosing probe through an opening formed in the dosing probe, a controller in communication with the actuator and configured to control delivery of the substance from the dosing probe, and a sensor in communication with the controller and configured to sense that the collar device is touching fur or skin of the animal and the dosing probe is directed towards fur or skin of the animal.

The disclosure relates to a topical workout muscle recovery composition that includes a pain reliever, water for hydration, an amino acid and inorganic salts, method of use along with a adhesive bandage pod (Appod). Muscle recovery and the pain often present after a workout are traditionally constituted treated by sitting into an ice bath and/or by taking nutritional supplements along with minerals as a drink or an energy bar by mouth or oral route. When taken orally, the supplements and minerals are provided to whole body, but during a workout, certain muscles will be used and go through fatigue and pain. The invention relates to topical workout muscle recovery compositions that includes a hands-free applicator along with Appod on to the skin that can be applied to specific part of the body and provide pain relief. In some embodiments, the amino acid and mineral supplement can be required for muscle recovery.

A headache therapeutic instrument is provided, which includes a wearable frame adapted to fit on a human head, massage and transdermal medicine permeation devices, liquid medicine delivery tubes, a liquid medicine delivery device and a liquid medicine storage box. The wearable frame is provided with at least one acupoint locating hole adapted to correspond to acupoints along the human head. The massage and transdermal medicine permeation devices are mounted on the wearable frame and correspond to the acupoint locating hole. The liquid medicine delivery device delivers medicines in the liquid medicine storage box to the massage and transdermal medicine permeation devices through the liquid medicine delivery tubes. The massage and transdermal medicine permeation devices can conduct medicine permeation and massage on corresponding acupoints.