A method of manufacturing a roll of bags includes: moving a layflat tubing from a feed end toward a produce end of a workstation; sealing the layflat tubing to form sealing lines along a width direction of the layflat tubing; punching the layflat tubing to form punching lines along the width direction; spraying, by a coding machine coupled to the workstation, at least one counting mark on the layflat tubing; cutting by the workstation, the layflat tubing along the width direction to form connected bags; and winding the connected bags into the roll of bags. The connected bags are separated by the punching lines, each bag has one of the sealing lines, and at least one bag has the at least one sprayed counting mark that counts its relative position in the roll of bags.

A method of manufacturing a spiral-wound PTFE gasket includes winding a laminated PTFE tape (300) around a shaft (305) that has an outer diameter that coincides with the gasket inner diameter to create a PTFE cylinder (315) having an outer diameter that coincides with the gasket outer diameter; sintering the PTFE cylinder (315); and removing a radial segment of the PTFE cylinder (315) to form the gasket (100), the radial segment having a thickness that coincides with the gasket thickness.

A method of manufacturing at least one flange by first rotating a tubular element and two sheet elements with respect to one another until a radially enlarged portion and adjacent hub section have been formed on the tubular element. The sheet element is impregnated by a thermosetting resin. When the resin has cured, the radially enlarged portion is cut along a cut line, thereby also dividing the tubular element in two parts and generating at least a first flange having a first flange section and a first hub section. Optionally, a second flange having a second flange section and a second hub section, is generated. In a preferred embodiment, the cut line is arranged in the middle of the radially enlarged portion, whereby two similar flanges are generated.

A method of manufacturing at least one flange (1a, 1b) by first rotating a tubular element (30) and two sheet elements (10, 20) with respect to one another until a radially enlarged portion (11) and adjacent hub section (21a,b) have been formed on the tubular element. The sheet element is impregnated by a thermosetting resin. When the resin has cured, the radially enlarged portion (11) is cut along a cut line (S), thereby also dividing the tubular element (30) in two parts (30a, 30b) and generating at least a first flange (1a) having a first flange section (11a) and a first hub section (21a). Optionally, a second flange (1b) having a second flange section (11b) and a second hub section (21b), is generated. In a preferred embodiment, the cut line (S) is arranged in the middle of the radially enlarged portion (11), whereby two similar flanges (1a, 1b) are generated.

A bioresorbable, implantable device having controlled drug delivery is disclosed herein. The bioresorbable, implantable device is configured as a film, a roll, a tube, and a stent. The bioresorbable, implantable device is configured to release an active ingredient (the drug) from the bioresorbable, implantable device when the bioresorbable, implantable device is implanted within a body. The bioresorbable, implantable device is configured to control the onset of the release of the drug, the sequence of drug delivery, and the duration of drug delivery by embedding the drug within at least one therapeutic layer positioned within bioresorbable, implantable device.

A multilayer bioresorbable stent having sustained drug delivery is disclosed herein. The bioresorbable stent releases a therapeutic substance from the body of the bioresorbable stent starting when the bioresorbable stent is implanted within an anatomical lumen and ending when the entire mass of the bioresorbable stent is no longer present within the anatomical lumen. The bioresorbable stent releases the therapeutic substance gradually during the treatment as the mass of the each layer of the bioresorbable stent erodes. Methods of making the therapeutic layers within the bioresorbable sent are further disclosed. Sustained drug delivery reduces the risk of late and very late stent thrombosis.