Disclosed are compositions that comprise an organic electrochemical mediator and a gasotransmitter salt which converts into a gasotransmitter via electron transfer. Also disclosed are bandages and wound dressings comprising the subject gasotransmitters, and methods of making a gasotransmitters, comprising exposing the compositions to a voltage sufficient to reduce the water soluble organic mediator. Further disclosed are methods of treating a variety of trauma and disease states by applying a therapeutically effective amount of at least one gasotransmitter thereto, and methods of generating an effective dose of the gasotransmitter generated from electrolytic reaction involving the gasotransmitter-generating compositions.

A wound care device for delivering topical oxygen therapy, negative pressure wound therapy, and a low intensity vacuum therapy for treatment of a wound. The wound care device may include an oxygen supply MEA, an oxygen consuming MEA, a vacuum pump and motor, a pressure sensor, and a power supply and electronic controls. A dressing may be connected to the wound care device for administering topical continuous oxygen therapy and simultaneous negative pressure wound therapy to a wound. A canister or exudate trap may be positioned between the dressing and the vacuum supply port of the vacuum pump to collect and store exudates from the wound. The canister may be combined with the dressing.

Heads for an aerosol container are disclosed. The head comprises a handle body having a base configured to be coupled to the aerosol container, an outlet, a flexible tube housed within the handle body. The flexible tube is configured to provide fluid communication between the container exit of the aerosol container and the outlet. And the head further comprises an elastically deformable actuator comprising a lever arm, and a coupling portion integrally formed with the lever arm and configured to be mounted around the flexible tube, wherein the coupling portion is further configured such that when the lever arm is deformed by a user, the coupling portion actuates on the valve body of the aerosol container. Aerosol containers comprising such heads and kits for treatments skin lesions are also disclosed.

A wound therapy device and method includes a skin contacting element, a reactor, and a reactor housing element. The skin contacting element is configured for covering an associated tissue site, the reactor for creating a pressure condition at the associated tissue site upon actuation thereof, and the reactor housing element for accommodating the reactor. The skin contacting element has a skin contacting side and an interface side, which is opposite the skin contacting side. The reactor housing element has a lower affixing side and an upper side, which is opposite the lower affixing side.

A hydration system comprising: a fluid reservoir comprising a means for reversibly mounting the hydration system to a structure; a supply tube fluidly coupled to the reservoir at its distal end; a reversibly compressible chamber fluidly coupled to the supply tube; a mouthpiece proximate to or at a proximal end of the collapsible chamber; and at least two valves that regulate the flow of fluid through the hydration system, wherein a distal valve is positioned at a distal end of the chamber or along the supply tube and closes in response to compression of the chamber to reduce backflow of fluid into the reservoir during compression, and a proximal valve is positioned at the mouth piece, biased closed for regulating the delivery of fluid out of the mouthpiece and prevents or reduces air induction into the mouthpiece.

A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

Face soaking devices (devices) and methods of use are described and disclosed. In some embodiments the device may comprise a vessel and a vessel neck gasket. The vessel may be configured to hold a liquid to submerge a face of a user or a portion thereof. The vessel neck gasket may be (removably) joined to the vessel. The vessel neck gasket may be configured to comfortably accommodate a portion of the user's neck. In some embodiments, the device may comprise a breathing apparatus that may be in removable contact with: the vessel, with a head rest subassembly, and/or with the user. The breathing apparatus may be configured to permit the user to breathe while the user's face may be submerged within the liquid. When the vessel may be filled with the liquid to at least a sufficient level, the user may soak the face or the portion thereof, such that the skin being soaked receives a benefit.

A hydrogen-delivering system for topical application of molecular hydrogen is provided. The system includes a housing that comprises at least one dry chemical and a liquid composition sealed therein, and that is configured to be attached to a target area of a subject's skin. The dry chemical and the aqueous composition are separated within the housing until the system is activated and the dry chemical and the aqueous composition are mixed to generate molecular hydrogen. The molecular hydrogen passes through a skin-facing surface of the housing, which is permeable to hydrogen and not permeable to the dry chemical and the aqueous composition, and is delivered to the subject's body.

A wound therapy system includes a negative pressure circuit configured to apply negative pressure to a wound, a pump fluidly coupled to the negative pressure circuit and operable to control the negative pressure within the negative pressure circuit, a pressure sensor configured to measure the negative pressure within the negative pressure circuit or at the wound and a controller communicably coupled to the pump and the pressure sensor. The controller is configured to execute a pressure testing procedure including applying a pressure stimulus to the negative pressure circuit, observe a dynamic pressure response of the negative pressure circuit to the pressure stimulus using pressure measurements recorded by the pressure sensor, and estimate a wound volume of the wound based on the dynamic pressure response.

An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.