Tamper-resistant pharmaceutical compositions have been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. The tamper-resistant compositions retard the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.

A composite core material and methods for making same are disclosed herein. The composite core material comprises mineral filler discontinuous portions disposed in a continuous encapsulating resin. Further, the method for forming a composite core material comprises the steps of forming a mixture comprising mineral filler, an encapsulating prepolymer, and a polymerization catalyst; disposing the mixture onto a moving belt; and polymerizing said encapsulating prepolymer to form a composite core material comprising mineral filler discontinuous portions disposed in a continuous encapsulating resin.

A 3-D (three dimensional) printing system is provided that includes a customized matrix having suitable material properties and geometric patterning to facilitate filling and retention of one or more filler material. The customized matrix defines the geometry and shape of the object. A filler mechanism that fills the customized matrix with one or more filler materials. The one or more filler materials retained within the customized matrix are cured or solidified to produce the object.

A 3-D (three dimensional) printing system is provided that includes a customized matrix having suitable material properties and geometric patterning to facilitate filling and retention of one or more filler material. The customized matrix defines the geometry and shape of the object. A filler mechanism that fills the customized matrix with one or more filler materials. The one or more filler materials retained within the customized matrix are cured or solidified to produce the object.

Tamper-resistance pharmaceutical compositions have been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. The tamper-resistant compositions retard the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.

Tamper-resistance pharmaceutical compositions have been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. The tamper-resistant compositions retard the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.

A composite core material and methods for making same are disclosed herein. The composite core material comprises mineral filler discontinuous portions disposed in a continuous encapsulating resin. Further, the method for forming a composite core material comprises the steps of forming a mixture comprising mineral filler, an encapsulating prepolymer, and a polymerization catalyst; disposing the mixture onto a moving belt; and polymerizing said encapsulating prepolymer to form a composite core material comprising mineral filler discontinuous portions disposed in a continuous encapsulating resin.

A composite core material and methods for making same are disclosed herein. The composite core material comprises mineral filler discontinuous portions disposed in a continuous encapsulating resin. Further, the method for forming a composite core material comprises the steps of forming a mixture comprising mineral filler, an encapsulating prepolymer, and a polymerization catalyst; disposing the mixture onto a moving belt; and polymerizing said encapsulating prepolymer to form a composite core material comprising mineral filler discontinuous portions disposed in a continuous encapsulating resin.

There is provided an inorganic particle composite body comprising a layer of a substrate formed of a plastically deformable solid material and an inorganic particle layer that is composed of inorganic particles that do not plastically deform under a condition under which the solid material plastically deforms, that contains gaps defined by the inorganic particles, and that adjoins the layer of the substrate, wherein part of the solid material is in at least part of the gaps in the inorganic particle layer. This inorganic particle composite body is produced by a method including a preparation step of preparing an inorganic particle structural body comprising a layer of a substrate formed of a plastically deformable solid material and an inorganic particle layer that is composed of inorganic particles that do not plastically deform under a condition under which the solid material plastically deforms, that contains gaps defined by the inorganic particles, and that adjoins the layer of the substrate; and a filling step of plastically deforming at least part of the solid material contained in the inorganic particle structural body, thereby filling at least part of the gaps in the inorganic particle layer with part of the plastically deformed solid material.

A composite core material and methods for making the same are disclosed herein. The composite core material comprises mineral filler discontinuous portions disposed in a continuous encapsulating resin. Further, the method for forming a composite core material comprises the steps of forming a mixture comprising mineral filler, an encapsulating prepolymer, and a polymerization catalyst; disposing the mixture onto a moving belt; and polymerizing said encapsulating prepolymer to form a composite core material comprising mineral filler discontinuous portions disposed in a continuous encapsulating resin.