A device to stimulate a scalp comprises an array of stimulating elements, the stimulating elements arranged along a circumference of at least one wheel, the wheel adapted to roll over the scalp. A method of treating/preventing a hair-condition comprises: subjecting the scalp to at least 200 distinct electrode-scalp contact events during a time-interval of at most one minute and dividable into 5 non-overlapping equal-duration sub-intervals covering the time-interval, method performed such that i. for at least a majority of the electrode-scalp contact events, no electrode of the event enters into the dermis; ii. a duration of each electrode contact event is at most 100 milliseconds; and iii. for each electrode contact event, an electrical current flows between the electrode and the scalp so as to deposit electrode-released ions of a first metal or of a second metal on the scalp, thereby forming a respective metal-ion-deposition island on the user's scalp.

This disclosure provides methods and systems for ultrasound assisted delivery of a medicant to tissue. The delivery of the medicant is enhanced by the application of high intensity ultrasound pulses, which generate an intertial cavitation effect, an acoustic streaming effect, or both. This disclosure also provides methods and systems for alleviating pain or swelling associated with the application of ultrasound energy by delivering an anesthetic across a stratum corneum layer according to the methods described herein.

A method for treating a patient includes providing a delivery device capable of generating a magnetic field, placing the device above or below the skin, and directing the agent into the patient's skin via the device. The therapeutic agent is directed to a treatment site through the skin. Systems for directing agents are also included herein.

In order to achieve the above or other aims, according to one aspect of the present disclosure, a skin care device is provided which comprises: a body comprising a grip section for a user to hold, and a head section positioned at the end of the grip section; a plurality of skin-contacting plates positioned at the end of the head section; a plurality of oscillators for providing oscillations to each of the skin-contacting plates; and a control unit which supplies an electrical current to the skin-contacting plates and controls the oscillators, wherein the positive electrode and the negative electrode of the control unit are respectively connected to different skin-contacting plates.

A wearable device for transdermal product supply comprises a head, which houses two ultrasonic resonators in resonance, with an outer cavity. A first, more distal resonator emits towards the skin at a first frequency and a second, more proximal resonator surrounds the cavity and emits parallel to the skin at a second frequency. One frequency is high-frequency sonophoresis (HFS) and the other is low-frequency sonophoresis (LFS). The second resonator comprises a hole in order to enable the waves from the first resonator to pass through. The waves from the second resonator pass through the head, the hole and the cavity, bouncing off an opposite area of the head and interfering with the waves from the first resonator. The interference between the waves creates a stationary field which increases the permeability of the skin, enabling a device with a reduced size to be incorporated into a wearable.

A skin stimulation tool to increase penetration and efficacy of topically applied products and medications. An example of the skin stimulation tool includes a substantially Y-shaped handle. The example skin stimulation tool also includes a first attachment on a first branch of the Y-shaped handle, and a second attachment on a second branch of the Y-shaped handle. The example skin stimulation tool also includes a first head portion rotatably mounted on the first attachment of the handle, and a second head portion rotatably mounted on the second attachment of the handle. Both of the head portions rotate when applied to a surface of the skin under linear motion of the handle.

Pressure waves are applied to intersect a focal volume or pressure field with a targeted tissue in conjunction with introducing a treatment agent into the targeted tissue to increase permeability of cells in the targeted tissue and cause more rapid absorption of the treatment agent in the targeted tissue.

A skin microbiota modulation device that includes a cold plasma assembly configured to generate a cold plasma stimulus including a partially ionized gas mixture and to interrogate a biological surface with the cold plasma stimulus; and a microbiota seeding assembly including one or more target species of micobiota, the microbiota seeding assembly configured to deliver the one or more target species of micobiota to the biological surface.

The disclosure discloses a drive component of a micro-needle system, a method for driving the same, a micro-needle system and a method for fabricating the same; wherein the drive component includes a substrate with a groove; a bottom electrode in the groove; an electro-active polymer layer, covering the bottom electrode, in the groove; and an upper flexible electrode covering the electro-active polymer layer; wherein the upper flexible electrode and the bottom electrode are configured to generate a voltage, and the electro-active polymer layer is configured to generate a strain under the voltage.

This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis.