Methods and systems for delivering drug particles to a target site are disclosed. An example method for implementing the subject matter described herein includes applying a drug delivery patch to a target site. The drug delivery patch can include a substrate, an electrode integrated with the substrate, and a fluid in the substrate having drug particles suspended in the fluid. The method further includes transmitting a signal to the drug delivery patch to power the drug delivery patch by inductive coupling. Powering the drug delivery patch causes the electrode in the drug delivery patch to motivate the drug particles towards a target site of the drug delivery patch.

A method for applying ultrasound to activate a cavitation enhancing agent in the presence of a therapeutic compound and a microbial biofilm is provided. The ultrasound energy causes the cavitation enhancing agent to cavitate in the ultrasound field. The cavitation of the resultant bubble causes fluid streaming and shear forces at and near the biofilm, causing enhanced penetration of the therapeutic compound into the biofilm, and resulting in improved efficacy of the therapeutic compound against the biofilm. The method further includes cavitation enhancing agents which can be loaded with oxygen gas or combined with microbubbles which carry oxygen gas, which further potentiate antibiotic efficacy against the biofilm.

The present disclosure relates to a medicament delivery device comprising at least one microneedle for delivering a medicament to a patient, and a system configured to enhance the penetration of the medicament into skin of the patient.

A benefit agent delivery system whereby benefit agents can be delivered on demand and/or a variety of different benefit agents at different concentrations can be delivered from the same system. The benefit agent delivery system includes a microcell layer comprising a plurality of microcells, wherein the microcells are filled with a carrier and a benefit agent. The microcells include an opening, wherein the opening is spanned by a sealing layer comprising a polymer and metallic material. Application of an electric field across the microcell layer and the sealing layer results in the migration of the metallic material from the sealing layer and the creation of a porous sealing layer, allowing the benefit agent to be released from the benefit agent delivery system.

Exemplary systems and methods associated with trans-tissue substance delivery using non-thermal plasma to porate skin or tissues using contoured dielectrics/electrodes and grounding techniques. In some embodiments, a substance delivery system may be incorporated into the plasma generating device for automatically controlled skin treatments. In other embodiments, a skin treatment patch may include the electrode and the treatment substance.

The present invention relates to agent delivery systems for application to biological tissues. More specifically, the present invention relates to devices and methods for the non-invasive delivery of agents (e.g. pharmaceuticals and the like) into and across biological tissues using ultrasound and nanoporous carriers.

A device comprising a housing having a handle end and a treatment end. The treatment end is configured to provide an antimicrobial treatment and a heat treatment. The treatment end comprises an applicator having an applicator surface for providing at least the heat treatment. The device includes a heat generation unit configured to heat the applicator surface in use, a source of antimicrobial agent, and a control unit operatively connected to at least the heat generation unit for controlling the heat generation unit. The device can be a hand-held device and used to apply topical treatment to a treatment area of a subject.

There is disclosed systems and methods for non-invasive delivery of an agent to biological tissues. Delivery of the agent to the tissues can be by one or more modalities. In some embodiments the systems and methods use agent carrier body including a tissue contacting surface for non-invasively engaging tissues under treatment. The tissue contacting surface can be at least partly defined by a plurality of protrusions that are in fluid communication with one or more reservoirs forming part of the agent carrier body. The protrusions may extend outward from an inside of a void and terminate at said tissue contacting surface.

A patch having at least first and second parts is applied to the skin to prepare the skin for a transdermal device to be applied subsequently. The second part defines the area of the skin in which the required preparation process should be carried out, either by removal of a third part to form an opening in the second part or by providing preparation means such as microneedles on the underside of the second part. The second part is then removed to leave the first part adhered to the skin, which can be used as a guide for correctly locating the transdermal device so that the working area of the device and the prepared area of the skin are in alignment.

Described are methods and therapeutic compositions and combinations for treating and/or preventing medical conditions, by application of non-thermal plasma to the skin. Also described are methods and compositions for treating and/or preventing various medical conditions, by application of non-thermal plasma to the skin, followed by topical application of a therapeutic composition.