The object of the present invention is to provide a test method using a novel administration method of an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract. It has been demonstrated that by sustainedly administering an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract by using a continuous administration device according to the present invention, a comparable effect is exerted at a very low dose compared with conventional administration methods such as oral administration. Therefore, the present invention can provide a test method using animals requiring less burden on a researcher, a treatment of patient at a low dose, and the like.

Drug delivery devices and methods of administering drugs to patients are provided. A device includes a reservoir containing a drug. The reservoir is defined by a wall having a water-permeable portion, such that the water-permeable portion permits water to enter the device and contact the drug. A restraining plug closes off an opening of the device such that transient microchannels form between an elastic portion of the device and the restraining plug, upon the generation of a sufficient pressure within the reservoir, to release the drug from the device. Methods of treating patients for neurogenic detrusor overactivity resulting from a spinal cord injury and/or for idiopathic overactive bladder and urinary incontinence are also provided.

An implantation needle has an implantable element receiving portion, a capsule receiving portion, and a tip portion. The capsule receiving portion has a fixing element such as a mechanical barrier or an adhesive surface. A kit is also provided that includes the implantation needle with an implantable element disposed in the implantable element receiving portion and a capsule disposed in the capsule receiving portion. The instant disclosure also relates to a method for administering an implantable element and a capsule to a subject. The method includes inserting an implantation needle of the implantation kit into a tissue of a subject and discharging the implantable element and capsule into the patient's tissue.

A marker delivery device including a handle assembly, a delivery catheter, and a connection interface. The handle assembly has an upper push rod positioned within the handle assembly. The upper push rod is adapted to translate inside the handle assembly. The delivery catheter is adapted to be inserted into a biopsy site. Also, the delivery catheter has a discharge opening containing a marker and the delivery catheter has a lower push rod positioned inside of the delivery catheter. The lower push rod is configured to engage the upper push rod and the lower push rod is adapted to deploy the marker from the delivery catheter into the biopsy site through the discharge opening with the translation of the upper push rod. The connection interface is configured to removably attach the handle assembly with the delivery catheter and the upper push rod with the lower push rod.

A pellet delivery system is provided that comprises a needle having an inner surface defining a passageway. The needle has a first portion that extends along a longitudinal axis and a curved second portion comprising an opening that is in communication with the passageway. The second portion extends transverse to the longitudinal axis. A pellet is positioned in the passageway. A plunger is slidably positioned in the passageway. The plunger comprises a shaft having a rounded tip configured to push the pellet through the first and second portions and out of the opening without the pellet becoming stuck within the passageway or the opening. Implants, systems, constructs, instruments and methods are disclosed.

A device for draining cysts includes a catheter system configured to deploy an absorbent material, including but not limited to a foam, into a cyst. The absorbent material advantageously absorbs fluid contained within the cyst, for example fluid that may remain following aspiration, reducing the potential for cyst recurrence. In various embodiments, the absorbent material may be bioabsorbable, radiolucent, echogenic, drug eluting, or a combination thereof. In some embodiments the device may further include or be coupled to a vacuum source which applies negative pressure to the cyst during foam delivery, thereby reduce the overall size and/or profile of the cyst.

Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

A medical device that may include an elongate member having a proximal end and a distal end, and a lumen disposed through the elongate member is disclosed. The medical device may also include an opening disposed at the distal end of the elongate member in communication with the lumen, and a pushing element disposed with the lumen. The medical device may also include at least one fiducial disposed within the lumen and distal to the pushing element, and a separating mechanism disposed at the distal end of the elongate member. The separating mechanism may be configured to apply a separating force to deploy the at least one fiducial.

The present invention is directed to a method of reducing the risk of infection following surgery utilizing the drug eluting surgical screw disclosed herein to secure an implant in an animal following surgery. The drug eluting screw includes a drug eluting component that can elute a therapeutic agent locally at the surface of the implant reducing the risk of infection.

The invention pertains to a kit for assembling a disposable applicator for inserting an implant, in particular a rod-like implant containing an active substance, under the skin of a human or animal, the kit comprising a first component, in turn comprising a main housing part providing a handle for grasping and maneuvering the applicator, a cannula, and a cannula holder mounted in the main housing part, the main housing part having an opening which allows introduction of an implant into the proximal end of the cannula or the cannula holder, and, a second component for closing said opening, in turn comprising a second housing part and a rod attached to or forming an integral whole with the second housing part and mountable inside the cannula or the cannula holder.