A drug depot delivery system includes a housing having a cavity. A cartridge is positioned within the cavity and includes a body having a channel. The body includes a first pair of rails and a second pair of rails. A plunger is slidably disposed in the housing and the cartridge. The plunger is configured to move a drug depot through the channel and out of the housing. Kits and methods of use are disclosed.

A drug pellet delivery system includes a housing having a cavity. A cartridge is positioned within the cavity and includes a body having a channel. The body includes a first pair of rails and a second pair of rails. A plunger is slidably disposed in the housing and the cartridge. The plunger is configured to move a drug depot through the channel and out of the housing. Kits and methods of use are disclosed.

Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.

Metered dispensing of a microfluidic amount of fluid from a reservoir comprises a pressure device which applies a discharge pressure for fluid ejection via a discharge line through a valve arrangement. The valve device has a first valve with a minimum closing time and a second valve with a minimum opening time. A control device provides control signals for operation for metered dispensing of the amount of fluid as follows: a shortened minimum opening time for freeing the discharge line for the fluid flow, which time is shorter than the minimum opening time of the second valve; and a shortened minimum closing time for closing the discharge line for the fluid flow, which time is shorter than the minimum closing time of the first valve. Furthermore, a hand-held device for locally piercing human or animal skin is disclosed.

In one embodiment, an implant includes a body having a distal end and a proximal end, the distal end including a sharp pointed tip that is configured to pierce and cut through tissue, an anchoring element extending outward from the body configured to prevent migration of the implant within tissue in which the implant has been implanted, and a therapeutic substance that is slowly released by the implant into the tissue over time, wherein the implant is made of a biocompatible and bioabsorbable material.

Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments the device has a housing having a top housing end, and a bottom housing end. The housing defines a housing channel. The device has a drug cartridge defining a depot channel aligned with the housing channel and configured to slidably accept the drug depot. The drug cartridge has at least a first occluding device configured to occlude the depot channel at a first position such that the drug depot cannot pass through the depot channel without force applied to the drug depot sufficient to deflect the first occluding device. The bottom end of the housing has a coupling configuration for engaging a cannula. A plunger has a push rod to expel the drug depot through the occluding device and the cannula.

A method for delivering one or more medication pellet to a subcutaneous insertion site with a round tipped obturator and blunt cannula is described. The obturator is received within the cannula. The cannula includes a tubular cannula body having a smooth anterior surface a medication slot disposed along the cannula body. The cannula body has an inner diameter that is at least 3 millimeters (mm). The cannula and obturator probe an incision into the subcutaneous tissue along an insertion path within the subcutaneous tissue. The obturator is removed from the cannula, and one or more medication pellet is placed in the medication slot. The cannula body again receives the obturator, which passes the pellet(s) through the cannula body with its anterior rounded tip so that the obturator pushes the pellet(s) through the cannula body. The pellet(s) exit the cannula body and are delivered aligned along the insertion path.

Described herein is a drug product delivery device and method of delivering a drug on a swab. The drug product delivery device may include an applicator platform housed within a rigid housing. The applicator platform may be in the form of a plunger. The foil drug reservoir cap creates a fluid storage chamber disposed between the foil drug reservoir cap and the plunger. A series of fluidic channels carry fluid from the fluid storage chamber to an applicator. A frangible seal is attached to the plunger between the fluid storage chamber and the applicator. The frangible seal blocks a fluid from moving from the fluid storage chamber into the series of fluidic channels. Actuation of the plunger causes the frangible seal to be ruptured, which causes the fluid to exit the fluid storage chamber and enter into the fluidic channels. The fluidic channels carry the fluid to the applicator.

An injector includes a push rod, a magazine tube, a gate, a cannula and an actuator. The magazine tube has a lumen extending from an inlet to an outlet thereof. The magazine tube slidingly receives at least one implant therein. The gate has a closed configuration in which it covers the outlet of the magazine tube and an open configuration in which it does not cover the outlet of the magazine tube. The cannula has a distal end configured to be inserted into an eye. A lumen of the cannula is in fluid communication with the lumen of the magazine tube when the gate is in the open configuration. Actuation of the actuator moves the gate from the closed configuration to the open configuration and causes translation of the pushrod through the magazine tube and the cannula.

An implantable and refillable device for delivering a drug compound is provided. The device comprises a reservoir within which the drug compound is capable of being retained, wherein the reservoir defines a first surface and a second surface opposing the first surface. A release structure comprising a hydrophobic polymer surrounds at least a portion of the reservoir. The release structure is in communication with the reservoir such that the drug compound can pass from the reservoir through the release structure. A septum is positioned adjacent to the first surface of the reservoir and a backing layer is positioned adjacent to the second surface of the reservoir.