Aspects of the present disclosure are directed toward apparatuses, methods, and systems comprising an introducer for facilitating subcutaneous implantation of a medical device. The introducer includes a housing, a tunneler extending from the housing, an inserter configured to move along a pathway to pass the medical device through the housing, a compartment configured to releasably hold and contain the medical device prior to the inserter moving the medical device, and a snap-feature integrally formed by the housing.

Various embodiments provide an apparatus, system method for treating neurological conditions by delivering solid form medication to the ventricles or other areas of the brain. Particular embodiments provide an apparatus and method for treating epilepsy and other neurological conditions by delivering solid form medication to ventricles in the brain wherein the medication is contained in a diffusion chamber so as to allow the medication to dissolve in the cerebrospinal fluid of the brain and then diffuse out of the diffusion chamber to be delivered to the ventricles and brain tissue. In one or more embodiments, portions of apparatus have sufficient flexibility to conform to the shape of the ventricles of the brain when advanced into them and/or to not cause deformation of the ventricle sufficient to cause a significant physiologic effect.

A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

In a method for implantation of a physically stabilized aggregate of living cells or tissue fragment is injected into a channel provided in soft tissue filled with an aqueous gel. Also discloses are methods of stabilizing such aggregates and fragments and of forming such channel in soft tissue as well as means for carrying out the methods.

Encapsulation devices, systems and methods are provided. In some embodiments, encapsulation devices for housing cells and providing various therapeutic benefits to a patient or host are provided. Encapsulation devices are provided that include a matrix or scaffold within a cell-receiving area or void, and methods of forming and preparing such a matrix are disclosed. Encapsulation devices that include channels are further provided, and the channels of the present disclosure are operable to convey fluid to internal areas of devices without restricting vascularization.

A delivery system for delivering a drug depot to a site within a patient, the system comprising: a cannula; a delivery stylet configured and dimensioned to be receivable by and slidable forwardly and backwardly within the cannula including to a position wherein a distal portion of the stylet protrudes beyond the distal end of the cannula; a drug depot retainable by the stylet at the distal end of the stylet, the drug depot being visualizable by a diagnostic imaging beam or modality; and an actuator for ejecting the drug depot from the stylet to a site within the body using fluid pressure. Also disclosed are methods using, and uses of, the delivery system, including for treating scoliosis.

Encapsulation devices are provided that comprise an outer wall defining an inner volume, the outer wall comprising a plurality of pores and a plurality of vasculature holes; and a plurality of channels traversing the inner volume, wherein each channel extends from one of the plurality of vasculature holes to another of the plurality of vasculature holes. The device is used for the implantation or delivery of cells, proteins, or other therapeutic molecules. Also provided are methods of treating a disorder in a subject using an encapsulation device described herein. The disclosed encapsulation devices have a porous surface and an internal network of channels passing through the device and connecting with the outside of the device.

Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

An injection for injecting at least one material into human keratinous materials that includes at least one treatment unit defining at least one cavity and at least one micro-implant made of said at least one material received in said cavity of the unit and having at least one portion having a same shape as the cavity; an injection device configured for applying a pressure to the at least one micro-implant to expel the latter out of the unit into the keratinous materials.

An implantation needle for inserting a subcutaneously insertable element into a body tissue, a kit for inserting a subcutaneously insertable element into a body tissue and a method of manufacturing an implantation needle are described. The implantation needle comprises at least one covering comprising at least one pharmaceutical compound. The pharmaceutical compound is configured to remain at least partially in the body tissue after insertion of the subcutaneously insertable element.