In sterile, additive manufacturing wherein one lamella is successively built upon an underlying lamella until an object is completed, a sterile manufacturing environment is provided. A major chamber large enough to accommodate the manufactured object has sterile accordion pleated sidewalls and a sterile top closed with flap valves. A minor chamber for supporting the nozzles positioned above the major chamber has similar valves in corresponding positions. Nozzles for material deposition penetrate the pair of valves to block air and particles from entry into the major chamber where the nozzles make layer by layer deposition of the object using XY areawise nozzle motion relative to the object as well as Z nozzle vertical motion with the major chamber explanding as the object is formed.

A bioprinting system comprises: a) a printing module containing at least one printhead for printing transferable objects of biological interest and at least one target, b) a feed source for the printhead for printing objects of biological interest, c) an activation means for the transfer of the objects of biological interest to the target, d) a means for relative displacement of the printhead with respect to the target, e) a sterilizable sealed enclosure, characterized in that the printing module is placed in the sterilizable sealed enclosure the activation means is located outside of the sterilizable sealed enclosure, and the sterilizable sealed enclosure has a leaktight interaction zone with the activation means.

A manufacturing method for a silicone rubber molded body that is to be used in an electrophotographic image forming apparatus includes a heating process of a precursor of a silicone rubber molded body. The heating process includes heating the precursor of a silicone rubber molded body and externally introducing an environmental gas and discharging the environmental gas to outside, to reduce an amount of a low molecular weight compound remaining in the precursor of a silicone rubber molded body.

Sputtering printheads, additive manufacturing systems comprising the same, and methods for additive manufacturing are provided. Sputtering printheads of the present invention use a plasma to sputter a feedstock material which is directed towards a target. A printhead can include a heater to heat the feedstock to, or near, the material's melting point as it is being sputtered to increase the deposition rate. A convergent nozzle can also increase the deposition rate. Printheads of the present invention are readily reconfigurable such that the same printhead can be used to deposit different materials, such as metals and non-metals, in succession by replacing the feedstock material and making changes to a few settings. Additive manufacturing systems of the present invention can be operated at normal room temperatures and pressure.

A production line is, suitable for the production of medicinal products that include at least one active ingredient. The production line includes an extruder for producing an extrudate from the active ingredient and at least one excipient intended to form an encapsulating matrix of the active ingredient, and a cooling member for cooling the extrudate at the outlet of the extruder. The extruder includes a barrel and at least two parallel screws housed in the barrel and interpenetrating with one another to mix the or each active ingredient with the or each excipient. The barrel is oriented vertically and the footprint occupied by the production line is less than 0.5 m.sup.2.

In sterile, additive manufacturing wherein one lamella is successively built upon an underlying lamella until an object is completed, a sterile manufacturing environment is provided. A major chamber large enough to accommodate the manufactured object has sterile accordion pleated sidewalls and a sterile top closed with flap valves. A minor chamber for supporting the nozzles positioned above the major chamber has similar valves in corresponding positions. Nozzles for material deposition penetrate the pair of valves to block air and particles from entry into the major chamber where the nozzles make layer by layer deposition of the object using XY areawise nozzle motion relative to the object as well as Z nozzle vertical motion with the major chamber expanding as the object is formed.

A method and device for pre-heating a first molding surface of a mold with an open position and a closed position defining a closed cavity between the first pre-heated molding surface and a second molding surface. A core is inductively heated outside the mold by placing the core inside a coil having an AC current passing there through. The core is inserted between the molding surfaces of the mold in the open position. The first molding surface is preheated by transferring the heat between the core and the first molding surface. The core is then removed and the mold is closed.

Provided herein are methods of forming and optimizing cured features on a surface including controlling the surface upon which the cured features are applied. Additionally, a system for forming and processing the topographical features on the membrane is also described, along with mechanical features at specific system stations. More particularly, provided herein are methods of forming and optimizing topographical features applied to a membrane surface by controlling the membrane surface and by controlling the direction and magnitude of pressure applied to the membrane (substrate), as well as initially partially curing the topographical features, followed by fully curing of the topographical features to form the membrane having topographical spacing features formed thereon.

A mold for casting a polymeric aircraft window panel includes a first mold half (12) having a first mold surface (24), and a second mold half (14) having a second mold surface (50). The first mold surface (24) and/or the second mold surface (50) have a shape conforming to a final shape for the major surfaces of the aircraft window panel. The first mold half (12) and/or the second mold half (14) can be formed of rolled, hydroformed, or stamped metal.

A method of repairing an affected area of a component of a fiber-reinforced polymer composite, especially having elongate or continuous reinforcing fibers in a polymer matrix, is disclosed. The method includes: providing a controlled atmosphere around the affected area of the component; heating the component in the affected area within the controlled atmosphere to cause pyrolysis or depolymerization of the polymer matrix in the affected area and thereby to remove the polymer matrix from the affected area; introducing polymer resin into a space left by the pyrolyzed or depolymerized matrix to refill the affected area.