Various approaches for regulating microbubbles in a treatment procedure for a target include generating a tissue-sensitivity map including multiple regions, at least one of the regions being outside the target region, the tissue-sensitivity map assigning, to each of the regions, a sensitivity level indicative of tissue sensitivity to the interaction between the microbubbles and an acoustic beam; select one or more interaction regions based at least in part on the tissue-sensitivity map; and activating the ultrasound transducer so as to generate the acoustic beam for interacting with the microbubbles in the selection interaction region(s) in the tissue-sensitivity map, thereby indirectly changing a characteristic of the microbubbles at the target region.

The present invention relates to methods of restoring cognitive function in aged individuals that do not exhibit a clinically detectable neurodegenerative disease. In one aspect, the present invention provides a method of improving cognitive function in an aged individual that does not have a neurodegenerative disease characterized by aggregation of a pathological protein, the method comprising or consisting of: applying a clinically safe level of acoustic energy to sites within a region of the brain, thereby saturating or substantially saturating the region with acoustic energy, thereby improving cognitive function in the aged individual.

An illustrative example embodiment of a device that facilitates administering a fluid into an individual's body tissue includes an ultrasound transducer configured to emit sound waves and detect reflected sound waves. At least one processor is configured to: control operation of the ultrasound transducer in a first mode for detecting a condition of the individual's body tissue, determine a suitable administration site based on the transducer operating in the first mode, instigate an indication regarding the suitable administration site, and control operation of the ultrasound transducer in a second, different mode for enhancing absorption of the fluid at the suitable administration site.

A transdermal delivery system: a delivery device; a band configured to connect the delivery device to a body part of a user, the delivery device comprising: a delivery chamber that is configured to receive a substance and a heating chamber configured to heat the substance in the delivery chamber so that the substance is liquified, vaporized, or both and exits the delivery chamber into contact with the body part of the user so that the substance is transdermally absorbed.

A device to stimulate a scalp comprises an array of stimulating elements, the stimulating elements arranged along a circumference of at least one wheel, the wheel adapted to roll over the scalp. A method of treating/preventing a hair-condition comprises: subjecting the scalp to at least 200 distinct electrode-scalp contact events during a time-interval of at most one minute and dividable into 5 non-overlapping equal-duration sub-intervals covering the time-interval, method performed such that i. for at least a majority of the electrode-scalp contact events, no electrode of the event enters into the dermis; ii. a duration of each electrode contact event is at most 100 milliseconds; and iii. for each electrode contact event, an electrical current flows between the electrode and the scalp so as to deposit electrode-released ions of a first metal or of a second metal on the scalp, thereby forming a respective metal-ion-deposition island on the user's scalp.

Disclosed are a sonotrode and its use for transdermal delivery of therapeutic or cosmetic compounds. The sonotrode 10 comprises a tubular neck 14 attached at a proximal end to a solid head 12 and ending at a distal end in a flared foot 16. When coupled to an ultrasonic transducer and applied to skin of a human or animal, the sonotrode enhances the delivery of compounds into the skin.

This disclosure provides methods and systems for ultrasound assisted delivery of a medicant to tissue. The delivery of the medicant is enhanced by the application of high intensity ultrasound pulses, which generate an intertial cavitation effect, an acoustic streaming effect, or both. This disclosure also provides methods and systems for alleviating pain or swelling associated with the application of ultrasound energy by delivering an anesthetic across a stratum corneum layer according to the methods described herein.

In order to achieve the above or other aims, according to one aspect of the present disclosure, a skin care device is provided which comprises: a body comprising a grip section for a user to hold, and a head section positioned at the end of the grip section; a plurality of skin-contacting plates positioned at the end of the head section; a plurality of oscillators for providing oscillations to each of the skin-contacting plates; and a control unit which supplies an electrical current to the skin-contacting plates and controls the oscillators, wherein the positive electrode and the negative electrode of the control unit are respectively connected to different skin-contacting plates.

A microrobot of which a drug release is controlled by a sound wave applied from outside, and a method of manufacturing the microrobot are disclosed. The method includes mixing and storing magnetic nanoparticles and a drug in a biodegradable resist, and forming a microrobot having a three-dimensional (3D) porous structure at the resist through two-photon polymerization (TPP). The microrobot is formed to control a release rate of the drug stored in the resist by a sound wave applied from the outside.

Embodiments of the invention introduces a method and system for focusing ultrasonic energy through intervening skull tissue into a target site within a target brain tissue region under the skull, includes a transducer emitter array, a transducer receiver array, a processor receiving echo signals from the receiver to determine correction factors for the transducer elements to compensate for refraction occurring due to intervening tissue. The correction factors may include phase correction factors, and the phases of excitation signals provided to the transducer elements may be calibrated focusing based upon the phase correction factors to focus the ultrasonic energy to the tissue at the target site.