The present disclosure includes system, methods, and kits relating to creating a second structure with a plurality of first structures at a target site inside or adjacent to a host object. The methods include the step of generating a field that non-invasively penetrates into the host object. The methods further include the step of positioning a first portion of the plurality of first structures at the target site using a force corresponding to the field. Additionally, the methods include the step of linking the first portion of the plurality of first structures with one another and/or the host object at the target site to form the second structure.

A cosmetic device includes: a body from which a first head portion and a second head portion protrude in directions different from each other; a front assembly disposed on the first head portion; a rear assembly disposed on the second head portion; and an iontophoresis electrode disposed to be spaced apart from the front assembly and the rear assembly on an outer surface of the body. The front assembly includes an inner electrode, an outer electrode disposed outside the inner electrode, and an ultrasonic vibrator disposed on a rear surface of the inner electrode to generate ultrasonic waves. The rear assembly includes a thermoelectric element and a cooling cover cooled by the thermoelectric element.

The present invention provides oxygenized nanobubbles and their uses in imaging and cancer treatment when combined with therapeutic drugs and precise ultrasound beam steering.

A biodegradable and biocompatible piezoelectric nanofiber platform for medical implant applications, including a highly sensitive, wireless, biodegradable force sensor for the monitoring of physiological pressures, and a biodegradable ultrasonic transducer for the delivery of therapeutics or pharmaceuticals across the blood-brain barrier.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

A catheter system for delivering ultrasonic energy to a treatment site within a body lumen, the catheter comprises a tubular body having a proximal end, a distal end and an energy delivery section positioned between the proximal end and the distal end and a plurality of ultrasound radiating members in the energy delivery section. The plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. Members of one electrical group are spatially interdigitated with members of another electrical group.

Delivery of compositions for treatment of skin tissue with photoactive plasmonic nanoparticles and light, with embodiments relating to delivery devices. Treatments are useful for cosmetic, diagnostic and therapeutic applications.

Various embodiments are described herein for a device for using acoustic or mechanical energy to perform an action at a target site of an object. The device comprises a conduit having an aperture disposed at the target site, a displacement signal source for generating a mechanical displacement signal, a coupling assembly having for coupling the displacement signal source to the conduit, a pressure controller coupled to the proximal end of the conduit to vary an amount of pressure in the conduit when obtaining a first entity from or delivering a second entity to the target site, and a control unit for controlling the displacement signal source to generate the mechanical displacement signal based on a desired acoustic or mechanical wave mode.

A drug delivery catheter includes a first axially extending elongate member, a second axially extending elongate member, and a main chamber wall. The inner surface of the main chamber wall defines a main chamber. The distal end of the main chamber wall is joined to the distal end of the second axially extending elongate member and the proximal end of the main chamber wall is joined to the distal end of the first axially extending elongate member such that the main chamber is disposed over a distal portion of at least the second elongate member. One or more shockwave-generating elements are disposed within the main chamber. The main chamber is in fluid communication with the lumen of the first elongate member. The drug delivery catheter is configured to deliver an active agent to a target site through the lumen of the first elongate member.

A method of delivery of an ultrasound-guided drug-loaded microbubble, an electronic device, and a computer-readable storage medium are provided. The method includes: emitting a first ultrasonic signal by utilizing an array transducer, to break a drug-loaded microbubble in a current breaking region; emitting a second ultrasonic signal by utilizing the array transducer, to obtain an ultrasound image; identifying a contour of a blood vessel of the breaking region based on the ultrasound image; and updating a characteristic parameter of the breaking region based on the contour of the blood vessel. According to the method, the breaking region is updated in real time based on the contour of the blood vessel, so that delivery accuracy of a drug-loaded microbubble is improved, and avoiding unnecessary tissue damage.