A system for the surface and subsurface delivery of therapeutic and cosmetic agents. The system includes a disposable attachable tip that can be pre-filled with medications or cosmetics and attached to hand pieces including electromagnetic and mechanical energy hand piece devices.

Increasing the immune response to a given cancer in a patient through increasing lymphatic flow out of the cancer region, following a primary action of the cancer that loads professional antigen-presenting cells/dendritic cells (APCs/DCs) with tumor-associated antigen (TAA) from the tumor into the interstitial fluid of the cancer region. Example primary actions are radio-therapy, both stereotactic and brachytherapy using implanted seeds, proton-therapy, and chemical- or radio-pharmaceutical therapy. Intra-capillary micro-bubbles in the tumor are brought to vibrate with incident ultrasound of appropriate frequency and amplitude, producing vibrations in the extra capillary tissue that produces an outward acoustic radiation force and micro shear waves in the tissue that increases transport of the interstitial fluid. This increases an outward flow from the proximal capillaries, increasing the interstitial fluid pressure that increases lymphatic outflow including APCs/DCs with TAA to primary draining lymph nodes (DLNs).

In one aspect, ultrasound-switchable fluorescence (USF) imaging systems are described herein. In some embodiments, such a system comprises an ultrasound source, a fluorophore excitation source, a contrast agent comprising a fluorophore, and an image recording device. The contrast agent, in some cases, comprises a fluorophore associated with a liposome carrier, wherein the contrast agent has a size of up to 1 μm. Further, in some implementations of a system described herein, the image recording device is controlled by a software trigger mode.

Taking an individualistic approach to the treatment of chronic pain may soon be the norm of modern-day medicine. The potential to control the type of medication, in addition to external stimulus including, but not limited to electrical, thermal, cold, or ultrasonic, presents itself in a new “toolbox.” The present invention relates to the management of chronic pain through non-opioid, multi modal compounded transdermal applications, whose properties are enhanced externally, by electrical, thermal, or mechanical energy. More specifically, the present invention encapsulates the customization of personal health, in analyzing, applying and contributing to the betterment of patient's well-being, adapting to patient's preference, biological requirements and regulating to various environments based on the individual's specific body part.

Methods and devices related to the fields of skin care, hair restoration and lip care wherein the systems may be used by an individual for infusing treatment media into skin or lips for cosmetic and rejuvenation purposes, hair restoration purposes or other therapeutic purposes.

A system for intravascular oxygenation may include a catheter shaft, a vibratory member, and an oxygen source. The catheter shaft may have a wall that extends from a proximal end to a distal end along a longitudinal axis to form a lumen. The distal end may terminate in an atraumatic tip that seals off an interior space of the lumen from an adjacent exterior space. The distal end may include a coiled spring whose coils are tightly disposed against adjacent coils. The vibratory member may be configured to produce and transmit via the wall, to the coiled spring, mechanical vibration or high-frequency acoustic energy. The oxygen source may be configured to be coupled to the proximal end and to deliver a flow of oxygen to an interior space for communication to the exterior space, through gaps that exist or are created between adjacent coils of the coiled spring.

Cancer imaging methods and cancer treatment methods using thermotherapy and drug delivery are disclosed herein. In one embodiment, the temperature of heated tissue is determined from radio-frequency data from an ultrasound transducer based upon a change in backscattered energy of acoustic harmonics. In another embodiment, a plurality of nanocarriers containing an anti-tumor medication are administered to a patient, and are excited in a first non-thermal ultrasound mode and/or a second thermal ultrasound mode using an ultrasound source. In yet another embodiment, a plurality of nanoparticles are administered to a patient, then at least some of the nanoparticles are heated along with tissue at a site of a tumor, and a photoacoustic imaging unit is used to determine a temperature of the heated tissue at the site of the tumor.

Integrated device for the non-invasive personalised treatment of skin blemishes includes: a handpiece for performing a percussive treatment on the body/face, causing a microtrauma on the wrinkle furrow, facilitating the natural recovery and the reduction of the wrinkle depth; a handpiece for carrying out an ablative micro-vibration treatment on the body, suitable to expand or compact the cutaneous tissue by alleviating wrinkles, stretch marks and scars with an exfoliating effect; a handpiece for performing a compressive micro-vibration treatment on the face, expanding the pores of the epidermis; a device for adjusting the rotation and vibration of the handpieces; an electric energy absorption sensor for each handpiece, communicating the detected data to a control unit which acts on the frequency adjustment devices obtaining a variation in the rotation and vibration frequency of the rotors, depending on the mechanical strength of the skin tissue; a communication interface.

Methods and devices related to the fields of skin care, hair restoration and lip care wherein the systems may be used by an individual for infusing treatment media into skin or lips for cosmetic and rejuvenation purposes, hair restoration purposes or other therapeutic purposes.

A drug delivery device using ultrasonic wave according to an embodiment of the present invention includes: an ultrasonic wave generating device for generating ultrasonic wave by receiving the alternating current electric energy generated from an external alternating current power supply unit; and a drug injection device configured to be coupled with and separated from the ultrasonic wave generating device and to inject a drug into the human body by using the ultrasonic wave energy transmitted from the ultrasonic wave generating device, wherein the ultrasonic wave generating device includes an ultrasonic wave generating portion for converting alternating current electric energy into ultrasonic wave and a medium portion for serving to transfer the ultrasonic wave energy generated by the ultrasonic wave generating portion to the drug accommodated in the drug injection device, and wherein the drug injection device includes a drug injection port capable of injecting the drug present in a separate container into the drug injection device.