Use of size-isolated microbubbles (SIMs) for sonoporation using a sonoporation system. The sonoporation system may include a SIM product administered in conjunction with an administered drug. Targeted ultrasound energy using an ultrasound device of the sonoporation system may result in sonoporation in response to cavitation of the SIM product in a targeted area of soft tissue. In turn, targeted delivery of the drug to the targeted area may occur. Results demonstrate improved outcomes using much reduced drug doses that allow for side effects and adverse reactions to be reduced or eliminated when used in conjunction with sonoporation as contemplated herein.

According to some embodiments there is provided a method for controlling a treatment effect on blood vessel tissue during an ultrasonic treatment, the method comprising positioning an ultrasonic transducer device in the blood vessel lumen; controlling a treatment effect by controlling fluid flow, wherein controlling comprises deploying a fluid restrictor at a location relative to the transducer effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. According to some embodiments there is provided an ultrasonic transducer device sized for placement in a body lumen, and comprising a fluid restrictor effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. In some embodiments, the fluid is blood.

A method of capturing radiographic images by wirelessly synchronizing steps performed by first and second components of a radiographic imaging system. Digital messages are sent between the first and second components and the send and receive times are recorded so that a transmission delay time and clock drift rate may be determined. A schedule of first component steps and a schedule of second component steps are generated based on the send and receive times, the transmission delay time and the clock drift rate.

A method and system for acoustic treatment of tissue are provided. Acoustic energy, including ultrasound, under proper functional control can penetrate deeply and be controlled precisely in tissue. In some embodiments, methods and systems are configured for acoustic tissue treatment based on creating an energy distribution function in tissue. In some embodiments, methods and systems are configured based on creating a temperature distribution function in tissue.

The invention provides devices and methods for use with an endoscope to deliver an agent to an internal tissue of a subject. The devices and methods use transient acoustic cavitation to transfer an agent directly from a fluid to the tissue.

A device for delivering to the skin, scalp, or lips a skin-coloring cosmetic composition, in particular for correcting a skin color disorder or performing a permanent or long-lasting make-up that includes a base carrying a plurality of resorbable microneedles for delivering the composition. The device being having a length (L.sub.n) of each microneedle (3) that is less than or equal to 50 mm, and the microneedles include a skin-coloring cosmetic composition.

A method of delivering a drug in a vessel includes positioning an inflatable balloon that is located at a distal end of an ultrasonic device within a lumen of the vessel, the inflatable balloon being deflated and coated with at least one drug; inflating the inflatable balloon; and transmitting a vibration to the distal end of the ultrasonic device to dislodge the drug from the inflated inflatable balloon and deliver the drug to an interior portion of the vessel.

A cavitation seed for drug delivery, and a drug delivery method using the same are disclosed. The cavitation seed according to the present invention comprises: a shell which forms the outer surface thereof to maintain the outer shape thereof within a fluid; and a core which is located inside the shell to determine buoyancy of the cavitation seed within the fluid. The cavitation seed can improve an effect of delivering a drug into a body since cavitation is induced by ultrasound at a position close to the epidermis. In addition, the cavitation seed can be applied in the delivery of various drugs as well as skin cosmetics, such as skin tone lightening agents, depilatories, hair restorers and skin fillers, skin analgesics, local anesthetics, agents for genetic diseases such as psoriasis, and agents for treatment of skin disease such as skin cancer.

According to some embodiments herein, systems for delivering therapeutic agents and/or methods of using such systems are provided. The systems can be configured to administer solution comprising therapeutic agent to a subject, and can further comprise an ultrasound applicator for applying ultrasound energy to the subject.

The invention includes catheters that have therapeutic agent- and therapeutic energy-delivery capability. In particular embodiments, the catheters include only a single therapeutic energy transducer that is configured to deliver energy to over half of the circumference of the catheter. The therapeutic catheters of the invention allow for faster and more effective thrombus removal because of the simultaneous delivery of therapeutic agents and energy.