A medical device includes a multi-layer body defining an interior space configured to contain a liquid. The multi-layer body includes a solid outer wall having a positive Poisson's ratio and a porous inner wall having a negative Poisson's ratio. A method of making a multi-layer body includes applying a stimulus to a precursor material to cause the precursor material to form a porous wall having a negative Poisson's ratio, and attaching a solid wall to the porous wall to form the multi-layer body, the solid wall having a positive Poisson's ratio. A suture includes one or more filaments, at least a first filament of the one or more filaments including a negative Poisson's ratio material. A medical device includes a biocompatible hydrogel, and the biocompatible hydrogel includes a composite of a first material having a negative Poisson's ratio and a second material having a positive Poisson's ratio.

A fluidics management system includes a cassette configured to receive saline from a saline source, receive contrast from a contrast source, and receive vacuum from a vacuum source. The cassette includes a plurality of saline connectors, each of the plurality of saline connectors configured to couple to one of a plurality of catheters to provide saline thereto, a plurality of contrast connectors, each of the plurality of contrast connectors configured to couple to one of the plurality of catheters to provide contrast thereto, and a plurality of vacuum connectors, each of the plurality of vacuum connectors configured to couple to one of the plurality of catheters to provide vacuum thereto.

Systems, devices and methods for removing a blood clot (10) from a blood vessel (12). Various uses of suction pressure and positive pressure, proximal and/or distal to the blood clot (10) assist with clot dislodgement and removal. The pressure(s) may be constant and/or cycled/pulsed to assist with clot dislodgement and/or removal. Various further devices assist with separating the clot (10) from the vessel (12).

A system for anal or stomal irrigation is described. The system includes a container, tube(s), an anal probe and a pump. The system further includes a connector, connecting the tube(s) to the container. The connector is configured for providing air venting prior to disconnecting the connector from the system. The connector is configured for cooperating with a coupling in the container of the system. The interface between the connector and the coupling provides a connected position and an air vented position. A method of de-pressurizing a container in an anal or stomal irrigation system is provided.

A medical device includes a multi-layer body defining an interior space configured to contain a liquid. The multi-layer body includes a solid outer wall having a positive Poisson's ratio and a porous inner wall having a negative Poisson's ratio. A method of making a multi-layer body includes applying a stimulus to a precursor material to cause the precursor material to form a porous wall having a negative Poisson's ratio, and attaching a solid wall to the porous wall to form the multi-layer body, the solid wall having a positive Poisson's ratio. A suture includes one or more filaments, at least a first filament of the one or more filaments including a negative Poisson's ratio material. A medical device includes a biocompatible hydrogel, and the biocompatible hydrogel includes a composite of a first material having a negative Poisson's ratio and a second material having a positive Poisson's ratio.

Disclosed herein is an implantable port and an implantable port-detecting device (IPDD). The implantable port includes a housing and a septum over a portion of the housing. At least one of the housing or the septum incorporates a contrast agent for locating the septum of the implantable port when the implantable port is implanted in a patient. The IPDD includes a light source, a light detector, and a display configured to display a presence of the implantable port. The light source is configured to emit light in a near-infrared (NIR) range of wavelengths as incident light for absorption by the contrast agent. The light detector is configured to detect light in the NIR range of wavelengths including luminescent light emitted by the contrast agent. The display is configured to display a presence of the implantable port when the luminescent light from the contrast agent is detected by the light detector.

Embodiments herein relate to catheter connection manifold bypass devices, cancer therapy delivery systems, and related methods. For example, a catheter connection manifold bypass device can be included having a fluid passage conduit with a proximal end and a distal end. The bypass device can also include a deformable tip disposed around the distal end of the fluid passage conduit. The deformable tip can fit within a distal portion of a cavity within a connection manifold for a fluid delivery catheter. The bypass device can include a proximal connection port that can be connected to the proximal end of the fluid passage conduit. The bypass device can also include a connection adapter defining a channel, wherein the fluid passage conduit passes through the channel. The distal end of the connection adapter can be configured to attach to a proximal end of the fluid delivery catheter. Other embodiments are also included herein.

A metered dose inhaler valve (26) has a reservoir portion (37) for assembly with a canister (14) for receiving a pressurised formulation of medicament and propellant, a metering valve body (96) defining a metering chamber, and a metering valve stem (24) having an outlet (56) and being axially moveable within the body. The stem moves between a first position in which the chamber is in fluid communication with the canister, and a second position in which the chamber is in fluid communication with the valve stem outlet. A metering valve seal is defined by the valve body and includes an opening through which the stem passes to form a dynamic seal between the stem and at least one of the outside atmosphere and the pressurized canister, where the opening is adapted to be stretched wider by the stem passing through it than it would be absent the valve stem.

Provided herein is a medical device including an instrument having a proximal end and a distal end, an introducer configured to moveably receive the instrument and having a housing having a proximal end, a distal end, and a sidewall therebetween defining an inner volume, and an end effector arranged at the distal end of the housing, the end effector configured to couple the introducer to an intravenous line and having a proboscis having a proximal end, a distal end, and a sidewall therebetween having a longitudinal axis and defining an interior that is configured to be in fluid communication with the inner volume of the introducer and the intravenous line, and at least one locking element configured to secure the end effector to the intravenous line.

A method for treatment of volume of interest (VOI), for example tumor, comprising a device for application of therapy in multi sites in a pre-defined volumetric array through a single needle insertion into the body. Therapies applied by this method include injection of therapeutic agents, including cytotoxic, immunologic and biologic drugs or drug combinations; radioactive substances; thermal ablation including radiofrequency ablation, microwave ablation, or cryoablation. The method addresses the problem of inadequate distribution of therapy throughout the VOI through a single needle insertion.