The present invention relates to a valve component for a medical valve assembly (10), the valve component comprising a deformable body (1) for location in a valve assembly housing, the deformable body comprising a conduit for receiving one or more medical instruments there-through, one or more helical grooves (9) being formed on a surface of the conduit, the one or more helical grooves extending into the deformable body from the conduit surface.

A vascular access site management system includes a stabilization body and a flow housing that is rotatable relative to the stabilization body. The flow housing may have a flow path extending through it to allow fluids to be introduced into or extracted from a patient via a catheter connected to the vascular access site management system. The vascular access site management system may also include a needle free connector fluidly connected to the flow housing via a section of tubing.

Valve assemblies having improved ability to selectively control flow of fluids through the catheter and prevent leakage of fluids from the proximal end of a catheter that is positioned within a patient. Such improved catheter valve assemblies also prevent leakage of fluids after repeated insertion and removal of medical instruments through the valve.

A catheter having a proximal opening, a distal opening, a lumen extending through the catheter and a side opening forming a rapid exchange port dimensioned and configured for insertion of a guiding device through the side opening. The catheter includes a seal movable between a closed position to reduce leakage through the side opening and an open position, wherein the seal is movable to an open position by the guiding device. The catheter can have one or more independently deflectable zones.

An integrated vascular delivery system and method of use, the system including: a frame having a catheter hub that provides a first anchoring point on the patient and receives a catheter insertable in the patient to transfer fluid at an insertion site, a stabilization hub that provides a second anchoring point on the patient, at least one lateral member extending between the catheter and stabilization hubs, and a fluidic channel. The frame operates in a folded configuration in which the hubs are coupleable and an unfolded configuration in which the anchoring points are distributed around the insertion site to anchor the frame to the patient, thereby stabilizing the catheter. In some embodiments, the system further includes a septum that helps prevent fluid leakage from the catheter hub, or a needle shield that covers the distal end of a needle used during catheter insertion.

Subcutaneous access hub embodiments are discussed herein that include housing embodiments having a plurality of cannula ports and a fluid passageway network that allows fluid communication between a fluid source and the plurality of cannula access ports. Such a configuration may allow a user such as a patient or clinician to releasably secure the housing to an outside surface of the patient's skin. Multiple locations on the patient's skin may then be accessed for deployment of one or more delivery cannulas via a plurality of cannula ports for delivery of fluid and from the fluid source to multiple subcutaneous locations below the patient's skin and timely movement of cannula access in the patient's skin without the need for relocating the housing.

Seals for medical fluid connectors are disclosed. A seal as molded may have an elliptical cross-sectional shape, an aperture on the top face of the seal, a well inside the seal, and a divet on the bottom face of the seal. The seal as molded becomes assembled when it is constrained by a housing. When constrained by the housing, the seal has a circular cross-sectional shape, and the aperture becomes an elongate insertion area. The elongate insertion area is closed such that fluid cannot permeate the seal as assembled. However, the seal as assembled is penetrable by a center post through the elongate insertion area, and the center post creates a fluid path through the seal when the center post penetrates the seal.

Described are syringe-to-syringe mixing systems, corresponding formulations, and methods of use including treatment methods.

A composition for fluorescent labeling comprises a compound (A) that is an ICG compound and a hydroxyl group-containing organic compound (B). In this way, it is possible to provide a composition for fluorescent labeling that has excellent compartment identifiability to identify an observation target more accurately, a long light emission time to observe the observation target for a long time, a small load to a biological body, and good economic efficiency.