Disclosed is a drug injection device that is implanted between the skull and the subcutaneous layer of an animal. The disclosed drug injection device includes: a main body that is positioned on the skull and implanted and fixed in the subcutaneous layer; a guide member that guides a trocar such that the drug is injected into brain parenchyma inside the skull of the animal; a cover member that is installed inside the main body and connected to the guide member in the center and has a hole for guiding drug injection trocar so as to be inserted; and a sealing member that is installed between the main body and the cover member and prevents reverse flow of drugs and the introduction of foreign substances.

A material includes a metallic, nanoporous structure having a plurality of nanopores having a porosity that allows passage of insulin but not IgG. The metallic nanoporous structure includes titanium, 316L stainless steel and may have a textured nano-sericeous surface. A nanoporous bicontinuous structure can be integrated with nanopores.

Fluid communication devices and supporting structures may be provided for use with intraosseous devices. Apparatus and methods may also be provided to communicate fluids with an intraosseous device.

Fluid communication devices and supporting structures may be provided for use with intraosseous devices. Apparatus and methods may also be provided to communicate fluids with an intraosseous device.

A drainage liquid sampling system is disclosed and includes a connector couplable with a drainage tube of a drainage system, the connector defining an inlet port, an outlet port, and a sample port, where the inlet port, the outlet port, and the sample port are in fluid communication with each other, and a sample container couplable with the sample port. A valve within the connector selectively allows and prevents flow of drainage liquid into the sample container. A cap couplable to the sample container also includes a valve. A system for draining liquid from a patient includes the drainage liquid sampling system.

A drainage liquid sampling system is disclosed and includes a connector couplable with a drainage tube of a drainage system, the connector defining an inlet port, an outlet port, and a sample port, where the inlet port, the outlet port, and the sample port are in fluid communication with each other, and a sample container couplable with the sample port. A valve within the connector selectively allows and prevents flow of drainage liquid into the sample container. A cap couplable to the sample container also includes a valve. A system for draining liquid from a patient includes the drainage liquid sampling system.

A flow modulation device is positioned around a hemodialysis fistula or a graft and includes a non-expandable outer jacket with an inwardly-inflatable flow-modulation chamber positioned inside thereof. The flow modulation chamber is configured to be in fluid communication with a control chamber via a flexible catheter. The control chamber includes a puncture-resistant housing having an inner cavity covered by a self-sealing elastic membrane sealingly attached thereto and configured for repetitive needle punctures. Upon injection of fluid into the control chamber via a needle puncture, the flow modulation chamber inflates inwardly to compress the hemodialysis fistula or the graft causing a reduction of blood flow therethrough.

An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit from the first end portion to the second end portion; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet at a first end thereof and an outlet at a second, opposed end thereof, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; a self-sealing material extending across the cannulation port; and a longitudinal passageway defined by the housing and the self-sealing material that extends from the inlet to the outlet of the housing. The housing of the at least one chamber is formed of a substantially rigid material such that, when a dialysis needle is inserted through the self-sealing material and the cannulation port, the needle is inhibited or prevented from extending through the posterior or the side walls of the housing.

The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.

A system for facilitating instrument delivery through a peripheral intravenous catheter may include a catheter adapter having a proximal end, a distal end, and a lumen extending there through. The catheter adapter may include a side port. The system may include an extension tube extending from the side port. The system may include a blood control valve disposed in the lumen of the catheter adapter. The system may include a peripheral intravenous catheter extending distally from the catheter adapter.