Intraocular implants and methods of making intraocular implants are provided. The intraocular implant can include a mask adapted to increase depth of focus. The method of manufacturing the implant can include positioning the mask with an aperture on a protruding pin of a positioning mold portion. The protruding pin can be configured to center the mask in the intraocular lens.

A method for adjusting a light adjustable lens in an optical system includes providing a light adjustable lens in an optical system; providing an ultraviolet light source to generate an ultraviolet light; and irradiating the generated ultraviolet light with a light delivery system onto the light adjustable lens with a center wavelength and with a spatial irradiance profile to change a dioptric power of the light adjustable lens by changing a refraction of the light adjustable lens in a refraction-change zone, thereby causing a wavefront sag, defined as half of a product of the change of the dioptric power and the square of a radius of the refraction-change zone, to be within 10% of its maximum over an ultraviolet spectrum.

A fracturable mask for treating presbyopia is disclosed. The fracturable mask can include an aperture for improving depth of focus. The fracturable mask can be embedded in an intraocular lens. The intraocular lens can include a lens body and the fracturable mask. The fracturable mask can be configured to fracture along a plurality of fracture pathways when the intraocular lens is manipulated. For example, fractures can be created in the mask during the process of injecting the intraocular lens through a cartridge tip into a patient's eye. The fractures can allow the resilient lens body to restore the fractured mask to its original, pre-injection optical performance specifications.

A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. The optical polymeric material can include a photosensitizer to increase the photoefficiency of the two-photo process resulting in the formation of the observed refractive structures. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45? to 90? to the optical axis. The at least one laser-modified GRIN layer comprises a plurality of adjacent refractive segments characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.

A system/method allowing intraocular lens (IOL) fabrication using a femtosecond laser is disclosed. The system and method generate a stream of pulses at a rate of at least 1 million pulses per second and a pulse length of 300 femtoseconds or less to sculpt a polymeric material blank (PMB) to form an IOL. The high repetition rate and short pulse length combine to permit IOL fabrication in less than 10 minutes. During this fabrication procedure a lens may be formed within the IOL by incorporating a refractive index shaping (RIS) structure within the IOL. Additionally, IOL haptics may be formed during this IOL formation process. This combination of physical feature generation and RIS structure generation permits per-patient customization of the IOL as it relates to sphere, cylinder, asphericity, multifocality, and/or higher optical aberrations (HOAs).

Aspheric optical lenses (e.g., intraocular lenses and contact lenses) are provided. The intraocular lens includes a body portion defining an anterior optical surface and an opposing posterior optical surface. The anterior optical surface includes a central region surrounded by a first outer region and a second outer region. The central region has a first asphericity profile. The first outer region has a second asphericity profile that is different than the first asphericity profile of the central region. The second outer region has a third asphericity profile that is different than the second asphericity profile of the first outer region. The overall asphericity profile of the optical lens provides different depths of focus for different pupil sizes. The result is an optical lens that provides increased depth of focus or pseudo-accommodation while maintaining desired optical power and performance.

A cast mold for manufacturing a contact lens or an intraocular lens, wherein the cast mold is provided with a central part and a bearing ring and a flexible connection between the central part and the bearing ring. Further, an injection mold is provided for manufacturing such a cast mold and a method for manufacturing such a cast mold. The injection mold is provided with a mold cavity with a plunger biased by a spring towards the mold cavity which serves for compensating shrinkage which occurs during the curing of the plastic injected into the injection mold. Also described is a method for manufacturing a contact lens or intraocular lens with the aid of the cast mold, as well as a contact lens or intraocular lens obtained with this method.

A mandrel (300) for holding an intraocular lens blank (200) during manufacturing includes an intraocular lens holding section configured to hold an intraocular lens, the intraocular lens holding section including: a central cavity (310) configured to hold a mounting material (315) such that the mounting material contacts an optic of the intraocular lens blank when the intraocular lens blank is mounted on the mandrel, and a projection (325) extending around a periphery of the central cavity, the projection having an outer wall (330) and an inner wall (335), and the projection being configured such that an outer peripheral edge of the intraocular lens blank extends up to or beyond the projection when the intraocular lens blank is mounted on the mandrel. A second mounting material (320) is deposited in the first trench (340) and then the haptic is milled using e.g. an end mill (365).

Provided is an intraocular lens having a novel structure with high utility which is easy to adapt to patients, and can improve quality of vision (QOV). In an intraocular lens, an optical characteristic is set rotationally symmetric around an optical axis, and a spherical aberration of a size corresponding to a coma aberration remaining in a patient's eye after extraction of a human lens of the eye is set.

Exemplary arrangements include articles and methods of producing plastic material objects. Such objects may be configured for use as an ocular implant, and intraocular lens, or a contact lens. Exemplary methods include ablating and polishing plastic material in a processing region of a plastic material object through operation of at least one laser such that some material in the region is de-crosslinked. Exemplary methods also include subsequently irradiating the processing region to at least partially re-cross-link the plastic material.