The present invention relates to the treatment or prevention of skeletal disorders, at particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

A system includes a film processing module, a processor, and memory. The processor and memory are in communication with the film processing module. The processor is configured to dynamically coordinate movement of the film processing module relative to a moving web of film and to perform a function on the web of film with the film processing module.

A system includes a film processing module, a processor, and memory. The processor and memory are in communication with the film processing module. The processor is configured to dynamically coordinate movement of the film processing module relative to a moving web of film and to perform a function on the web of film with the film processing module.

A method of making a recycled plastic product includes collecting recyclable plastic materials. The recyclable plastic materials are separated into a plurality of single grade batches of recyclable plastic materials. Each single grade batch is ground into a single grade group of recyclable plastic chips. A single grade portion is weighed out from each single grade group of chips. Each single grade portion is equal in weight within a range of plus or minus 15 percent. Each single grade portion is mixed together to form a multiple grade mixture of recyclable plastic chips. The multiple grade mixture is heated to form a multiple grade blend of molten recyclable plastic. The multiple grade blend is cooled into a form of a solid recycled plastic product. The recycled plastic product comprises multiple grades of recyclable plastic and a volume large enough to encompass a 1.0-inch diameter sphere.

The method of producing a shower tray using a shower tray blank is disclosed. The method may comprise identifying a drain location on the shower tray blank. The method may further comprise deflecting the shower tray blank at an internal location relative to a shower tray perimeter of the shower tray blank along the depth dimension to a deflected state. The method may also comprise cutting the shower tray blank along a plane generally perpendicular to a depth dimension of the shower tray blank when the shower tray blank is in the deflected state to form the shower tray and a discarded portion. An apparatus for producing a shower tray is also disclosed.

A process for manufacturing an expanded polystyrene foam article from used expanded polystyrene foam articles in combination with virgin polystyrene foam, the process comprising the steps of: stacking a plurality of individual used expanded polystyrene foam articles in a vertical block machine to occupy at least 20% of the internal volume in the block machine; conveying virgin polystyrene beads into the internal volume of the vertical block machine to occupy at least some of the remaining internal volume of the block machine by mixing the virgin polystyrene with the used stacked foam articles; and heating the internal volume of the block machine to a temperature of at least 75° C. by supplying pressurised steam into the heated internal volume of the block machine to fuse the virgin expanded polystyrene beads and the stacked expanded polystyrene foam articles to form the expanded polystyrene foam article.

The present invention is an artificial tree consisting of a shape such as conical wherein there is an artificial outer layer, e.g., artificial grass, a solidified foam core, and a post molded into the foam core.

A mechanical assembly for securing a first sheet to a second sheet includes a first projection having a first sidewall and a first top wall. The first sidewall extends from the first top wall at a first acute angle. The first sidewall includes a first top end and a first bottom end. A first discontinuity is defined in the first sidewall between the first top end and the first bottom end. A first base wall extends from the first bottom end. The first base wall extends generally parallel to the first top wall.

A mechanical assembly for securing a first sheet to a second sheet includes a first projection having a first sidewall and a first top wall. The first sidewall extends from the first top wall at a first acute angle. The first sidewall includes a first top end and a first bottom end. A first discontinuity is defined in the first sidewall between the first top end and the first bottom end. A first base wall extends from the first bottom end. The first base wall extends generally parallel to the first top wall.

A method of joining overlapping thermoplastic membrane components in which a first thermoplastic membrane component and a second thermoplastic membrane component are positioned in overlapping relationship between a pair of complementary molding surfaces, with at least one of the complementary molding surfaces being defined by an electrically conductive metal susceptor. Heat is generated in the metal susceptor and transferred by thermal conduction from the metal susceptor to overlapping portions of the first and second thermoplastic membrane components to locally melt and coalesce at least a portion of the thermoplastic material of the first thermoplastic membrane component and at least a portion of the thermoplastic material of the second thermoplastic membrane component. The molten thermoplastic material of the first and second thermoplastic membrane components forms a zone of coalesced thermoplastic material that, upon cooling, forms a solid weld joint that fusion welds the first and second thermoplastic membrane components together.