An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.

An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.

An apparatus having an adjustable ambient air-oxygen blender that adjustably mixes ambient air with an oxygen supply, especially where a size, diameter or flow rate of an orifice is mechanically adjustable so as to control a quantitative mixing function of the blender.

An apparatus having an adjustable ambient air-oxygen blender that adjustably mixes ambient air with an oxygen supply, especially where a size, diameter or flow rate of an orifice is mechanically adjustable so as to control a quantitative mixing function of the blender.

A stand-alone chamber or multi-chamber inhalation system has at least two alternative vaporized test liquid supply systems for passive or self-administered delivery of vaporized test fluid and air to one or more test chambers, which can be passive or restraint chambers, based on operator selection of delivery on and off times in a passive mode or actuation of an actuator in the chamber by a test animal in a self-administered mode. In one case, a multiple inhalation chamber system has two or more separate test fluid delivery systems and provides options for selective passive uniform drug delivery to multiple chambers or selective delivery of two or more different drugs to different groups of chambers from different delivery systems so that two different drugs or different concentrations of delivered drugs can be tested simultaneously.

A stand-alone chamber or multi-chamber inhalation system has at least two alternative vaporized test liquid supply systems for passive or self-administered delivery of vaporized test fluid and air to one or more test chambers, which can be passive or restraint chambers, based on operator selection of delivery on and off times in a passive mode or actuation of an actuator in the chamber by a test animal in a self-administered mode. In one case, a multiple inhalation chamber system has two or more separate test fluid delivery systems and provides options for selective passive uniform drug delivery to multiple chambers or selective delivery of two or more different drugs to different groups of chambers from different delivery systems so that two different drugs or different concentrations of delivered drugs can be tested simultaneously.

The adapter for an oxygen delivery device is a continuation-in-part application configured for use with a previously disclosed oxygen delivery device. The adapter for an oxygen delivery device is modified to work with a single oxygen canister. The adapter for an oxygen delivery device attaches to the single oxygen canister. The adapter for an oxygen delivery device is configured for use with the distribution apparatus of the prior disclosure. The adapter for an oxygen delivery device comprises a canister adapter and a manual flow valve. The canister adapter is a mechanical structure that offsets the distribution apparatus such that the distribution apparatus will receive oxygen from the single oxygen canister. The manual flow valve is a plunger valve that attaches to the distribution apparatus. The manual flow valve controls the flow of oxygen into the distribution apparatus from the canister adapter.

The adapter for an oxygen delivery device is a continuation-in-part application configured for use with a previously disclosed oxygen delivery device. The adapter for an oxygen delivery device is modified to work with a single oxygen canister. The adapter for an oxygen delivery device attaches to the single oxygen canister. The adapter for an oxygen delivery device is configured for use with the distribution apparatus of the prior disclosure. The adapter for an oxygen delivery device comprises a canister adapter and a manual flow valve. The canister adapter is a mechanical structure that offsets the distribution apparatus such that the distribution apparatus will receive oxygen from the single oxygen canister. The manual flow valve is a plunger valve that attaches to the distribution apparatus. The manual flow valve controls the flow of oxygen into the distribution apparatus from the canister adapter.

An inhaler article (110) comprises a body (112) extending along a longitudinal axis (A) from a mouthpiece end (113) to a distal end (114), a capsule cavity (116) defined within the body, and a distal end element (118) disposed at the distal end and extending to the capsule cavity. The distal end element comprises an element distal end (120), an element inner end (122), a solid core portion (124), and at least two grooves (126). The solid core portion extends from the element distal end to the element inner end. The at least two grooves are helical grooves that rotate about solid core portion along the longitudinal axis from the element distal end to the element inner end. The at least two helical grooves extend along an outer surface (128) of the distal end element.

An inhaler article (110) comprises a body (112) extending along a longitudinal axis (A) from a mouthpiece end (113) to a distal end (114), a capsule cavity (116) defined within the body, and a distal end element (118) disposed at the distal end and extending to the capsule cavity. The distal end element comprises an element distal end (120), an element inner end (122), a solid core portion (124), and at least two grooves (126). The solid core portion extends from the element distal end to the element inner end. The at least two grooves are helical grooves that rotate about solid core portion along the longitudinal axis from the element distal end to the element inner end. The at least two helical grooves extend along an outer surface (128) of the distal end element.