Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Disclosed is respiratory assistance apparatus comprising a flow generator configured to provide breathing gases to a patient, the breathing gases comprising supplemental oxygen provided from an oxygen source. The respiratory assistance apparatus controller is configured determine a target oxygen concentration of the breathing gases and calculate an estimated future value of the patient's blood oxygen concentration based on a difference between an initial oxygen concentration of the breathing gases and the target oxygen concentration of the breathing gases, and the patients blood oxygen concentration.

Disclosed is respiratory assistance apparatus comprising a flow generator configured to provide breathing gases to a patient, the breathing gases comprising supplemental oxygen provided from an oxygen source. The respiratory assistance apparatus controller is configured determine a target oxygen concentration of the breathing gases and calculate an estimated future value of the patient's blood oxygen concentration based on a difference between an initial oxygen concentration of the breathing gases and the target oxygen concentration of the breathing gases, and the patients blood oxygen concentration.

A security tag can prohibit unauthorized usage of a device or product. The device may include an electronic nicotine delivery systems (“ENDS”) device, which may include aerosol delivery devices such as smoking articles that produce aerosol. The security tag can prevent usage until authorized. Attempts at usage without authorization can result in the device being unusable. The authorization may include identity confirmation or age verification.

A security tag can prohibit unauthorized usage of a device or product. The device may include an electronic nicotine delivery systems (“ENDS”) device, which may include aerosol delivery devices such as smoking articles that produce aerosol. The security tag can prevent usage until authorized. Attempts at usage without authorization can result in the device being unusable. The authorization may include identity confirmation or age verification.

A microneedle applicator is provided. A microneedle applicator according to an embodiment of the present invention comprises: a microneedle array; an operation member disposed on the upper portion of the microneedle array and operating such that a user applies an external force so as to insert a microneedle into skin; a housing for accommodating the microneedle array and the operation member; a first guide member disposed in at least one position on a lateral portion of the operation member or on a lateral portion of an interworking member of the operation member; and a second guide member which is disposed on the inner surface of the housing in a position corresponding to the first guide member so as to be engaged with the first guide member, and allows the first guide member to slide so as to prevent the microneedle array from rotating or horizontally distorting when the microneedle array uniformly vertically descends due to the external force.

A microneedle applicator is provided. A microneedle applicator according to an embodiment of the present invention comprises: a microneedle array; an operation member disposed on the upper portion of the microneedle array and operating such that a user applies an external force so as to insert a microneedle into skin; a housing for accommodating the microneedle array and the operation member; a first guide member disposed in at least one position on a lateral portion of the operation member or on a lateral portion of an interworking member of the operation member; and a second guide member which is disposed on the inner surface of the housing in a position corresponding to the first guide member so as to be engaged with the first guide member, and allows the first guide member to slide so as to prevent the microneedle array from rotating or horizontally distorting when the microneedle array uniformly vertically descends due to the external force.

Systems, products, compounds and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide nasal delivery system. The system can comprise one or more containers for compounds that when mixed are adapted to produce nitric oxide gas, at least one container with a nitrite compound and at least one container with an acid compound. Containers can be ruptured so that the compounds may be mixed and produce nitric oxide gas. The nitric oxide gas may then be delivered to a user via one or more of the nasal cavities and/or mouth.

Systems, products, compounds and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide nasal delivery system. The system can comprise one or more containers for compounds that when mixed are adapted to produce nitric oxide gas, at least one container with a nitrite compound and at least one container with an acid compound. Containers can be ruptured so that the compounds may be mixed and produce nitric oxide gas. The nitric oxide gas may then be delivered to a user via one or more of the nasal cavities and/or mouth.